Cited by 581Immune Response and InflammationMicroRNA in disease regulationNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

Open access

Androulidaki, Ariadne, Iliopoulos, Dimitrios, Arranz, Alicia, Doxaki, Christina, Schworer, Steffen, Zacharioudaki, Vassiliki, Margioris, Andrew N., Tsichlis, Philip N., Tsatsanis, Christos·2009·Immunity

DOI 10.1016/j.immuni.2009.06.024PMC PMC2865583

Open this paper in CoChat — free account Open PDF

Abstract

MicroRNAs regulated by lipopolysaccharide (LPS) target genes that contribute to the inflammatory phenotype. Here, we showed that the protein kinase Akt1, which is activated by LPS, positively regulated miRNAs let-7e and miR-181c but negatively regulated miR-155 and miR-125b. In silico analyses and transfection studies revealed that let-7e repressed Toll-like receptor 4 (TLR4), whereas miR-155 repressed SOCS1, two proteins critical for LPS-driven TLR signaling, which regulate endotoxin sensitivity and tolerance. As a result, Akt1(-/-) macrophages exhibited increased responsiveness to LPS in culture and Akt1(-/-) mice did not develop endotoxin tolerance in vivo. Overexpression of let-7e and suppression of miR-155 in Akt1(-/-) macrophages restored sensitivity and tolerance to LPS in culture and in animals. These results indicate that Akt1 regulates the response of macrophages to LPS by controlling miRNA expression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2009.06.024

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860
IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling
Kobayashi, K. S., Hernandez, L. D., Galán, J. E., Janeway, C. A., Medzhitov, R. M., & Flavell, R. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00827-9 · Cited by 1,310
Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock
Tili, E., Michaille, J.-J., Cimino, A., Costinean, S., Dumitru, C. D., Adair, B., Fabbri, M., Alder, H., Liu, C. G., Calin, G. A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5082 · Cited by 1,304
Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3
Martin, M., Rehani, K., Jope, R. S., & Michalek, S. M. (2005) · Nature Immunology · doi:10.1038/ni1221 · Cited by 1,099
MicroRNAs: new regulators of immune cell development and function
Baltimore, D., Boldin, M., O’Connell, R. M., Rao, D. S., & Taganov, K. D. (2008) · Nature Immunology · doi:10.1038/ni.f.209 · Cited by 1,097
MicroRNA Control in the Immune System: Basic Principles
Xiao, C., & Rajewsky, K. (2009) · Cell · doi:10.1016/j.cell.2008.12.027 · Cited by 1,020
MicroRNAs in the Human Heart
Thum, T., Galuppo, P., Wolf, C., Fiedler, J., Kneitz, S., Laake, L. W. V., Doevendans, P. A., Mummery, C. L., Borlak, J. T., Haverich, A., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.687947 · Cited by 890
Inositol phosphatase SHIP1 is a primary target of miR-155
O'Connell, R. M., Chaudhuri, A. A., Rao, D. S., & Baltimore, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902636106 · Cited by 826
TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway
Dumitru, C. D., Ceci, J. D., Tsatsanis, C., Kontoyiannis, D. L., Stamatakis, K., Lin, J., Patriotis, C., Jenkins, N. A., Copeland, N. G., Kollias, G. A., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00210-5 · Cited by 810
Self-citation

Show all 46 references

Sorted by citations

Items 301–400 of 581

Multi-Step Regulation of the TLR4 Pathway by the miR-125a~99b~let-7e Cluster
Curtale, G., Renzi, T. A., Mirolo, M., Drufuca, L., Albanese, M., Luca, M. D., Rossato, M., Bazzoni, F., & Locati, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02037 · Cited by 40
MicroRNA-21 contributes to suppress cytokines production by targeting TLR28 in teleost fish
Bi, D., Cui, J., Chu, Q., & Xu, T. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.01.016 · Cited by 39
microRNA-mediated regulation of innate immune response in rheumatic diseases
Luo, X., Ranade, K., Talker, R., Jallal, B., Shen, N., & Yao, Y. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4194 · Cited by 39
Promiscuous Effects of Some Phenolic Natural Products on Inflammation at Least in Part Arise from Their Ability to Modulate the Expression of Global Regulators, Namely microRNAs
Tili, E., & Michaille, J. (2016) · Molecules · doi:10.3390/molecules21091263 · Cited by 40
Borna disease virus encoded phosphoprotein inhibits host innate immunity by regulating miR-155
Zhai, A., Qian, J., Kao, W., Li, A., Li, Y., He, J., Zhang, Q., Song, W., Fu, Y., Wu, J., et al. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.02.009 · Cited by 39
Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases
Hassan, T. M., McKiernan, P. J., McElvaney, N. G., Cryan, S., & Greene, C. M. (2012) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.11.175 · Cited by 38
Role of microRNAs in Vascular Remodeling
Fang, Y., & Yeh, C. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150921105031 · Cited by 38
MicroRNAs as therapeutics for future drug delivery systems in treatment of lung diseases
Dua, K., Hansbro, N. G., Foster, P. S., & Hansbro, P. M. (2016) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0343-6 · Cited by 38
Epigenetic regulation of Toll-like receptors and its roles in type 1 diabetes
Xie, Z., Huang, G., Wang, Z., Luo, S., Zheng, P., & Zhou, Z. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1660-7 · Cited by 38
Macrophages from a type 1 diabetes mouse model present dysregulated Pl3K/AKT, ERK 1/2 and SAPK/JNK levels
Tessaro, F. H. G., Ayala, T. S., Bella, L. M., & Martins, J. O. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.11.014 · Cited by 38
Erratum to: Transforming Growth Factor b1/Smad4 Signaling Affects Osteoclast Differentiation via Regulation of miR-155 Expression
Zhao, H., Zhang, J., Shao, H., Liu, J., Jin, M., Chen, J., & Huang, Y. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.1303 · Cited by 38
Characteristics of microRNAs and their potential relevance for the diagnosis and therapy of the acute respiratory distress syndrome: from bench to bedside
Cardinal‐Fernández, P., Ferruelo, A., Esteban, A., & Lorente, J. A. (2015) · Translational research · doi:10.1016/j.trsl.2015.11.004 · Cited by 37
miR-200a-3p regulates TLR1 expression in bacterial challenged miiuy croaker
Wang, Y., Xu, G., Han, J., & Xu, T. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.06.004 · Cited by 37
The Transcriptional Foundations of Sp110-mediated Macrophage (RAW264.7) Resistance to Mycobacterium tuberculosis H37Ra
Wu, Y., Guo, Z., Yao, K., Miao, Y., Liang, S., Liu, F., Wang, Y., & Zhang, Y. (2016) · Scientific Reports · doi:10.1038/srep22041 · Cited by 42
Differential expression of miRNA-146a and miRNA-155 in gastritis induced by Helicobacter pylori infection in paediatric patients, adults, and an animal model
Cortés-Márquez, A. C., Mendoza-Elizalde, S., Arenas‐Huertero, F., Trillo-Tinoco, J., Valencia‐Mayoral, P., Consuelo‐Sánchez, A., Zarate-Franco, J., Dionicio-Avendaño, A. R., Herrera-Esquivel, J. D. J., Carrera, E. G. R., et al. (2018) · BMC Infectious Diseases · doi:10.1186/s12879-018-3368-2 · Cited by 37
miR‐155expression in antitumor immunity: The higher the better?
Michaille, J., Awad, H., Fortman, E. C., Efanov, A. A., & Tili, E. (2018) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22698 · Cited by 37
MicroRNA regulated macrophage activation in obesity
Li, C., Qu, L., Farragher, C., Vella, A. T., & Zhou, B. (2019) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2019-0011 · Cited by 38
Emerging therapies for hemophilia: controversies and unanswered questions
Arruda, V. R., Doshi, B. S., & Samelson‐Jones, B. J. (2018) · F1000Research · doi:10.12688/f1000research.12491.1 · Cited by 37
Neorogioltriol and Related Diterpenes from the Red Alga Laurencia Inhibit Inflammatory Bowel Disease in Mice by Suppressing M1 and Promoting M2-Like Macrophage Responses
Daskalaki, M., Vyrla, D., Harizani, M., Doxaki, C., Eliopoulos, A. G., Roussis, V., Ioannou, E., Tsatsanis, C., & Kampranis, S. C. (2019) · Marine Drugs · doi:10.3390/md17020097 · Cited by 36
Self-citation
Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19
Rocha, J. L. M., de Oliveira, W. C. F., Noronha, N. D. C., dos Santos, N. C. D., Covas, D. T., Picanço‐Castro, V., Swiech, K., & Malmegrim, K. C. R. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10032-7 · Cited by 38
Profiling microRNA expression in bovine alveolar macrophages using RNA-seq
Végh, P., Foroushani, A. B. K., Magee, D. A., McCabe, M. S., Browne, J. A., Nalpas, N., Conlon, K. M., Gordon, S. V., Bradley, D. G., MacHugh, D. E., et al. (2013) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2013.08.004 · Cited by 36
MicroRNAs in Macrophages: Regulators of Activation and Function
Sprenkle, N. T., Serezani, C. H., & Pua, H. H. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200467 · Cited by 39
ncRNA-regulated immune response and its role in inflammatory lung diseases
Xie, N., & Liu, G. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00286.2015 · Cited by 36
miR-155 and miR-146a collectively regulate meningitic Escherichia coli infection-mediated neuroinflammatory responses
Yang, B., Yang, R., Xu, B., Fu, J., Qu, X., Li, L., Dai, M., Tan, C., Chen, H., & Wang, X. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02165-4 · Cited by 35
Genome-wide miRNA screening reveals miR-310 family members negatively regulate the immune response in Drosophila melanogaster via co-targeting Drosomycin
Li, Y., Li, S., Li, R., Xu, J., Jin, P., Chen, L., & Ma, F. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.11.014 · Cited by 35
A Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4
Kueanjinda, P., Roytrakul, S., & Palaga, T. (2015) · Scientific Reports · doi:10.1038/srep12784 · Cited by 34
MicroRNA Roles in the NF-κB Signaling Pathway during Viral Infections
Gao, Z., Dou, Y., Chen, Y., & Zheng, Y. (2014) · BioMed Research International · doi:10.1155/2014/436097 · Cited by 34
Identification of micro‐ RNA networks in end‐stage heart failure because of dilated cardiomyopathy
Zhu, X., Wang, H., Liu, F., Chen, L., Luo, W., Su, P., Li, W., Yu, L., Yang, X., & Cai, J. (2013) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12096 · Cited by 34
Toll Like Receptors in systemic sclerosis: An emerging target
O’Reilly, S. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.09.001 · Cited by 36
MK2 mediates macrophage activation and acute lung injury by regulating let-7e miRNA
Wu, Y., He, H., Ding, Y., Liu, S., Zhang, D., Wang, J., Jiang, H., Zhang, D., Sun, L., Ye, R. D., et al. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00019.2018 · Cited by 35
miRNA and Other Non-Coding RNAs as Promising Diagnostic Markers.
Trzybulska, D., Vergadi, E., & Tsatsanis, C. (2018) · Europe PMC (PubMed Central) · Cited by 34
Self-citation
GSK‐3β inhibition protects the rat heart from the lipopolysaccharide‐induced inflammation injury via suppressing FOXO3A activity
Li, Z., Zhu, H., Liu, C., Wang, Y., Wang, D., Liu, H., Cao, W., Hu, Y., Lin, Q., Tong, C., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14656 · Cited by 34
Modulation of immune responses following solid organ transplantation by microRNA
Sarma, N. J., Tiriveedhi, V., Ramachandran, S., Crippin, J. S., Chapman, W. C., & Mohanakumar, T. (2012) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2012.09.020 · Cited by 34
Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density
Li, X., Mikhalkova, D., Gao, E., Zhang, J., Myers, V. D., Zincarelli, C., Lei, Y., Song, J., Koch, W. J., Peppel, K., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00755.2010 · Cited by 33
Protective Effect and Mechanism of Boswellic Acid and Myrrha Sesquiterpenes with Different Proportions of Compatibility on Neuroinflammation by LPS-Induced BV2 Cells Combined with Network Pharmacology
Miao, X., Zheng, L., Zhao, Z.-Z., Su, S., Zhu, K. Y., Guo, J., Shang, E., Qian, D., & Duan, J. (2019) · Molecules · doi:10.3390/molecules24213946 · Cited by 33
Clinical Application of Serum microRNAs in Atherosclerotic Coronary Artery Disease
Kabłak-Ziembicka, A., Badacz, R., & Przewłocki, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226849 · Cited by 33
Serum miR-155 as a potential biomarker of male fertility
Tsatsanis, C., Bobjer, J., Rastkhani, H., Dermitzaki, E., Katrinaki, M., Margioris, A. N., Giwercman, Y. L., & Giwercman, A. (2015) · Human Reproduction · doi:10.1093/humrep/dev031 · Cited by 32
Self-citation
The Akt1 Isoform Is Required for Optimal IFN-β Transcription through Direct Phosphorylation of β-Catenin
Gantner, B. N., Jin, H., Qian, F., Hay, N., He, B., & Ye, R. D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201669 · Cited by 33
The effects of quercetin on microRNA and inflammatory gene expression in lipopolysaccharide-stimulated bovine neutrophils
Chuammitri, P., Srikok, S., Saipinta, D., & Boonyayatra, S. (2016) · Veterinary World · doi:10.14202/vetworld.2017.403-410 · Cited by 32
Skeletal Muscle Atrophy in Simulated Microgravity Might Be Triggered by Immune-Related microRNAs
Teodori, L., Costa, A., Campanella, L., & Albertini, M. C. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01926 · Cited by 31
MicroRNAs: a crossroad that connects obesity to immunity and aging
Rakib, A., Kiran, S., Mandal, M., & Singh, U. P. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00320-w · Cited by 35
Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer
Wei, Y., Zhu, M., & Schober, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061756 · Cited by 32
MKP-1 coordinates ordered macrophage-phenotype transitions essential for stem cell-dependent tissue repair
Perdiguero, E., Kharraz, Y., Serrano, A. L., & Muñoz-Cánoves, P. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19374 · Cited by 30
MicroRNAs and Tumor Vasculature Normalization: Impact on Anti-Tumor Immune Response
Matejuk, A., Collet, G., Nadim, M., Grillon, C., & Kiéda, C. (2013) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-013-0231-4 · Cited by 30
MicroRNA-155: a Novel Armamentarium Against Inflammatory Diseases
Wu, X., Pais, E. M. A., Li, L., Chen, J., Miao, L., Asare, P. F., & Guanwei, F. (2016) · Inflammation · doi:10.1007/s10753-016-0488-y · Cited by 30
MiR-146a negatively regulates dectin-1-induced inflammatory responses
Du, L., Chen, X., Duan, Z., Liu, C., Zeng, R., Chen, Q., & Li, M. (2017) · Oncotarget · doi:10.18632/oncotarget.16958 · Cited by 29
miR-155-3p: processing by-product or rising star in immunity and cancer?
Dawson, O., & Piccinini, A. M. (2022) · Open Biology · doi:10.1098/rsob.220070 · Cited by 31
Identification of a circulating microRNAs biomarker panel for non-invasive diagnosis of coronary artery disease: case–control study
Abdallah, H. Y., Hassan, R., Fareed, A., Abdelgawad, M., Mostafa, S. A., & Mohammed, E. A.-M. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02711-9 · Cited by 30
Let-7b ameliorates Crohn’s disease-associated adherent-invasive E coli induced intestinal inflammation via modulating Toll-Like Receptor 4 expression in intestinal epithelial cells
Guo, Z., Cai, X., Guo, X., Xu, Y., Gong, J., Li, Y. Z., & Zhu, W. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.08.029 · Cited by 31
Targeting α7-nAChR by galantamine mitigates reserpine-induced fibromyalgia-like symptoms in rats: Involvement of cAMP/PKA, PI3K/AKT, and M1/M2 microglia polarization
Atta, A. A., Ibrahim, W. W., Mohamed, A. F., & Abdelkader, N. F. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175810 · Cited by 29
The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress
Arranz, A., Venihaki, M., Mol, B., Androulidaki, A., Dermitzaki, E., Rassouli, O., Ripoll, J., Stathopoulos, E. N., Gomariz, R. P., Margioris, A. N., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-261 · Cited by 30
Self-citation
MicroRNAs
Alemdehy, M. F., & Erkeland, S. J. (2012) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328353d4e9 · Cited by 31
MicroRNA-146a and microRNA-155 show tissue-dependent expression in dental pulp, gingival and periodontal ligament fibroblasts in vitro
Sipert, C. R., Morandini, A. C., Dionísio, T. J., Trachtenberg, A. J., Kuo, W. P., & Santos, C. F. (2014) · Journal of Oral Science · doi:10.2334/josnusd.56.157 · Cited by 30
Dynamic macrophage polarization-specific miRNA patterns reveal increased soluble VEGF receptor 1 by miR-125a-5p inhibition
Melton, D. W., Lei, X., Gelfond, J., & Shireman, P. K. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00098.2015 · Cited by 29
Hsa-miR-99b/let-7e/miR-125a Cluster Regulates Pathogen Recognition Receptor-Stimulated Suppressive Antigen-Presenting Cells
Hildebrand, D., Eberle, M.-E., Wölfle, S. J., Egler, F., Sahin, D., Sähr, A., Bode, K. A., & Heeg, K. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01224 · Cited by 29
Alteration of microRNA 340-5p and Arginase-1 Expression in Peripheral Blood Cells during Acute Ischemic Stroke
Yoo, H., Kim, J., Lee, J.-M., Lee, J.-M., Kim, J.-K., Kim, J.-K., & Oh, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1295-2 · Cited by 29
Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways
Li, Y., Wang, N., Ma, Z., Wang, Y., Yuan, Y., Zhong, Z., Hong, Y., & Zhao, M. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4919 · Cited by 29
Secret messengers: Extracellular RNA communication in the immune system
Nation, G. K., Saffold, C. E., & Pua, H. H. (2021) · Immunological Reviews · doi:10.1111/imr.13027 · Cited by 28
miRNA as a Modulator of Immunotherapy and Immune Response in Melanoma
Nguyen, M.-H. T., Luo, Y.-H., Li, A.-L., Tsai, J.-C., Wu, K., Chung, P., & Ma, N. J.-L. (2021) · Biomolecules · doi:10.3390/biom11111648 · Cited by 30
Macrophage polarization in spinal cord injury repair and the possible role of microRNAs: A review
Wang, J., Tian, F., Cao, L., Du, R., Tong, J., Ding, X., Yuan, Y., & Wang, C. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22914 · Cited by 33
Deficiency in Toll-interacting protein (Tollip) skews inflamed yet incompetent innate leukocytes in vivo during DSS-induced septic colitis
Diao, N., Zhang, Y., Chen, K., Yuan, R., Lee, C., Geng, S., Kowalski, E., Guo, W., Xiong, H., Li, M., et al. (2016) · Scientific Reports · doi:10.1038/srep34672 · Cited by 28
Unique molecular signatures of microRNAs in ocular fluids and plasma in diabetic retinopathy
Smit‐McBride, Z., Nguyen, A. T., Yu, A. K., Modjtahedi, S. P., Hunter, A. A., Rashid, S., Moisseiev, E., & Morse, L. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235541 · Cited by 28
An evaluation of the molecular mode of action of trans-resveratrol in the Porphyromonas gingivalis lipopolysaccharide challenged neuronal cell model
Bahar, B., & Singhrao, S. K. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-06024-y · Cited by 28
MicroRNA genes preferentially expressed in dendritic cells contain sites for conserved transcription factor binding motifs in their promoters
Jansen, B., Sama, I. E., Eleveld-Trancikova, D., Hout-Kuijer, M. A. V., Jansen, J. H., Huynen, M. A., & Adema, G. J. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-330 · Cited by 28
A Newly Identified MicroRNA, mmu-miR-7578, Functions as a Negative Regulator on Inflammatory Cytokines Tumor Necrosis Factor-α and Interleukin-6 via Targeting Egr1 in Vivo
Zhang, J., Xie, S., Ma, W., Yu, T., Tian, Y., Huang, X., & Zhang, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.351197 · Cited by 28
Endotoxin Effects on Cardiac and Renal Functions and Cardiorenal Syndromes
Virzì, G. M., Clementi, A., Brocca, A., & Ronco, C. (2017) · Blood Purification · doi:10.1159/000480424 · Cited by 28
A dual negative regulation model of Toll-like receptor 4 signaling for endotoxin preconditioning in human endotoxemia
Yang, Q., Calvano, S. E., Lowry, S. F., & Androulakis, I. P. (2011) · Mathematical Biosciences · doi:10.1016/j.mbs.2011.05.005 · Cited by 27
Diverse pro-inflammatory endotoxin recognition systems of mammalian innate immunity
Weiss, J. P., & Barker, J. H. (2018) · F1000Research · doi:10.12688/f1000research.13977.1 · Cited by 28
MiR-181c protects cardiomyocyte injury by preventing cell apoptosis through PI3K/Akt signaling pathway
Li, X., Zhong, J., Zeng, Z., Wang, H., Li, J., Liu, X., & Yang, X. (2020) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt-20-490 · Cited by 27
Cell-Free Biological Approach for Corneal Stromal Wound Healing
Jhanji, V., Billig, I., & Yam, G. H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.671405 · Cited by 27
MicroRNA in Immune Regulation
Wu, C.-J., & Lu, L. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_65 · Cited by 28
MicroRNAs as Regulators of Phagocytosis
Gierlikowski, W., & Gierlikowska, B. (2022) · Cells · doi:10.3390/cells11091380 · Cited by 25
Environmental control of microRNAs in the nervous system: Implications in plasticity and behavior
Codocedo, J. F., & Inestrosa, N. C. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.010 · Cited by 25
Role of microRNAs in Disorders of Gut–Brain Interactions: Clinical Insights and Therapeutic Alternatives
Singh, R., Zogg, H., & Ro, S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11101021 · Cited by 25
Model systems to analyze the role of miRNAs and commensal microflora in bovine mucosal immune system development
Liang, G., Malmuthuge, N., Guan, L. L., & Griebel, P. J. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.10.014 · Cited by 25
Identification of differentially expressed miRNAs through high-throughput sequencing in the chicken lung in response to Mycoplasma gallisepticum HS
Zhao, Y., Hou, Y., Zhang, K., Yuan, B., & Peng, X. (2017) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2017.04.004 · Cited by 25
The role of miRNAs in cytokine signaling
McCoy, C. E. (2011) · Frontiers in bioscience · doi:10.2741/3845 · Cited by 24
MicroRNA-Regulated Pathways in Hematological Malignancies: How to Avoid Cells Playing Out of Tune
Fatica, A., & Fazi, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020930 · Cited by 24
Recent advances in understanding acute respiratory distress syndrome
Wohlrab, P., Kraft, F., Tretter, V. E., Ullrich, R., Markstaller, K., & Klein, K. U. (2018) · F1000Research · doi:10.12688/f1000research.11148.1 · Cited by 26
Upregulation of miR-150-5p alleviates LPS-induced inflammatory response and apoptosis of RAW264.7 macrophages by targeting Notch1
Deng, X., Lin, Z., Zuo, C., & Fu, Y. (2020) · Open Life Sciences · doi:10.1515/biol-2020-0058 · Cited by 24
Persistent TLR4 Activation Promotes Hepatocellular Carcinoma Growth through Positive Feedback Regulation by LIN28A/Let-7g miRNA
Chen, I., Cheng, A.-C., Liu, Y., Yan, C., Cheng, Y.-C., Chang, C., & Tseng, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158419 · Cited by 24
MiR-221 negatively regulates innate anti-viral response
Du, H., Cui, S., Li, Y., Yang, G., Wang, P., Fikrig, E., & You, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200385 · Cited by 24
Regulatory Non-coding RNAs in Atherosclerosis
Schober, A., Maleki, S. S., & Nazari-Jahantigh, M. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_423 · Cited by 25
Lipopolysaccharide-Induced Immunological Tolerance in Monocyte-Derived Dendritic Cells
Mbongue, J. C., Vanterpool, E., Firek, A. F., & Langridge, W. H. R. (2022) · Immuno · doi:10.3390/immuno2030030 · Cited by 26
Pulmonary MicroRNA Expression Profiling in an Immature Piglet Model of Cardiopulmonary Bypass-Induced Acute Lung Injury
Li, W., Ma, K., Zhang, S., Zhang, H., Liu, J., Wang, X., & Li, S. (2014) · Artificial Organs · doi:10.1111/aor.12387 · Cited by 23
Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated BST-2/tetherin regulation
Jones, P. H., & Okeoma, C. M. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.08.042 · Cited by 23
Inhibition of microRNA-155 modulates endotoxin tolerance by upregulating suppressor of cytokine signaling 1 in microglia
Sun, X., Sun, J., Shao, X., Feng, J., Yan, J., & Qin, Y. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6032 · Cited by 24
A heteroglycan from the cyanobacterium Nostoc commune modulates LPS-induced inflammatory cytokine secretion by THP-1 monocytes through phosphorylation of ERK1/2 and Akt
Ólafsdóttir, Á., Thorlacius, G. E., Ómarsdóttir, S., Ólafsdóttir, E. S., Víkingsson, A., Freysdóttir, J., & Harðardóttir, I. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.04.023 · Cited by 22
Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway
Watts, B. A., George, T., Sherwood, E. R., & Good, D. W. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00064.2017 · Cited by 23
Prediction of key regulators and downstream targets of E. coli induced mastitis
Sharifi, S., Pakdel, A., Ebrahimie, E., Aryan, Y., Ghaderi‐Zefrehei, M., & Reecy, J. M. (2019) · Journal of Applied Genetics · doi:10.1007/s13353-019-00499-7 · Cited by 22
Therapeutic Effects of Puerarin Against Anterior Ischemic Optic Neuropathy Through Antiapoptotic and Anti-Inflammatory Actions
Nguyen-Ngo-Le, M.-A., Wen, Y., Ho, Y.-C., Kapupara, K., & Tsai, R. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27129 · Cited by 22
Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide (LPS)-induced inflammatory response
Liu, Y., Wan, X., Yuan, Y., Huang, J., Jiang, Y., Zhao, K., Wang, Y., Liu, Y., Wang, Q., & Jin, H. (2021) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2000826 · Cited by 22
AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner
Zenke, K., Muroi, M., & Tanamoto, K. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.12.002 · Cited by 23
Sepsis and high-density lipoproteins: Pathophysiology and potential new therapeutic targets
Parolini, C. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167761 · Cited by 24
Epigenetics mediate environment
Pacheco, K. (2012) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e328351518f · Cited by 21
Crosstalk Between Insulin and Toll-like Receptor Signaling Pathways in the Central Nervous system
Hemmati, F., Ghasemi, R., Ibrahim, N. M., Dargahi, L., Mohamed, Z., Raymond, A. A., & Ahmadiani, A. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8631-3 · Cited by 21
MicroRNAs as master regulators of immune responses in transplant recipients
Kaul, V., & Krams, S. M. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000148 · Cited by 21
Inflammatory intracellular pathways activated by electronegative LDL in monocytes
Estruch, M., Sánchez‐Quesada, J. L., Ordóñez‐Llanos, J., & Benı́tez, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.05.010 · Cited by 21
Dectin-1 is required for miR155 upregulation in murine macrophages in response toCandida albicans
Agustinho, D. P., de Oliveira, M. A., Tavares, A. H., Derengowski, L. D. S., Stolz, V., Guilhelmelli, F., Mortari, M. R., Kuchler, K., & Silva-Pereira, I. (2016) · Virulence · doi:10.1080/21505594.2016.1200215 · Cited by 21
Let‐7e inhibits TNF‐α expression by targeting the methyl transferase EZH2 in DENV2‐infected THP‐1 cells
Zhang, Y., Zhang, Q., Gui, L., Cai, Y., Deng, X., Li, C., Guo, Q., He, X., & Huang, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26576 · Cited by 21

Authors: Androulidaki, A., Iliopoulos, D., Arranz, A., Doxaki, C., Schworer, S., Zacharioudaki, V., Margioris, A. N., Tsichlis, P. N., & Tsatsanis, C.
Affiliations: University of Crete (GR)
Harvard University (US)
Tufts Medical Center (US)
Corresponding author: Tsatsanis, Christos
ORCID: Iliopoulos, Dimitrios
Tsichlis, Philip N.
Tsatsanis, Christos
Venue: Immunity
Publisher: Elsevier BV
Published: 2009-08
Volume: 31
Issue: 2
Pages: 220-231
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2009.06.024
PMC: PMC2865583
OpenAlex: W2067647130
Cited by: 581
References: 46
Citations by year: 2026: 14 · 2025: 13 · 2024: 17 · 2023: 22 · 2022: 28 · 2021: 26 · 2020: 27 · 2019: 25 · 2018: 42 · 2017: 42 · 2016: 50 · 2015: 47 · 2014: 45 · 2013: 54 · 2012: 53
FWCI: 18.41
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1446 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA057436, N02 CO041101, 2-CO-41101)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: AKT1, macrophages, lipopolysaccharide, microRNA, let-7e, miR-155, miR-181c, miR-125b, TLR4, SOCS1, endotoxin tolerance, endotoxin sensitivity, LPS signaling, inflammation
MeSH terms: Suppressor of Cytokine Signaling 1 Protein, Animals, Cell Line, Immune Tolerance, Lipopolysaccharides, Macrophages, Mice, Inbred C57BL, Mice, Knockout, MicroRNAs, Suppressor of Cytokine Signaling Proteins, Proto-Oncogene Proteins c-akt, Toll-Like Receptor 4, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Kinase Akt1 Controls Macrophage Response to Lipopolysaccharide by Regulating MicroRNAs

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks