Erythropoietin Contrastingly Affects Bacterial Infection and Experimental Colitis by Inhibiting Nuclear Factor-κB-Inducible Immune Pathways

Nairz, Manfred; Schroll, Andrea; Moschen, Alexander R.; Sonnweber, Thomas; Theurl, Milan; Theurl, Igor; Taub, Nicole; Jamnig, Christina; Neurauter, Daniela; Huber, Lukas A.; Tilg, Herbert; Moser, Patrizia L.; Weiss, Günter

doi:10.1016/j.immuni.2011.01.002

Erythropoietin Contrastingly Affects Bacterial Infection and Experimental Colitis by Inhibiting Nuclear Factor-κB-Inducible Immune Pathways

Summary Erythropoietin (EPO) is the principal cytokine regulating erythropoiesis through its receptor, EPOR. Interestingly, EPORs are also found on immune cells with incompletely understood functions. Here, we show that EPO inhibits the induction of proinflammatory genes including tumor necrosis …