Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

Yogev, Nir; Frommer, Friederike; Lukas, Dominika; Kautz-Neu, Kordula; Karram, Khalad; Ielo, Daniele; von Stebut, Esther; Probst, Hans-Christian; van den Broek, Maries; Riethmacher, Dieter; Birnberg, Tal; Blank, Thomas; Reizis, Boris; Korn, Thomas; Wiendl, Heinz; Jung, Steffen; Prinz, Marco; Kurschus, Florian C.; Waisman, Ari

doi:10.1016/j.immuni.2012.05.025

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

Mature dendritic cells (DCs) are established as unrivaled antigen-presenting cells (APCs) in the initiation of immune responses, whereas steady-state DCs induce peripheral T cell tolerance. Using various genetic approaches, we depleted CD11c(+) DCs in mice and induced autoimmune CNS inflammation.…