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Cited by 377

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

Open access
Liao, Hua-Xin, Bonsignori, Mattia, Alam, S. Munir, McLellan, Jason S., Tomaras, Georgia D., Moody, M. Anthony, Kozink, Daniel M., Hwang, Kwan-Ki, Chen, Xi, Tsao, Chun-Yen, Liu, Pinghuang, Lu, Xiaozhi, Parks, Robert J., Montefiori, David C., Ferrari, Guido, Pollara, Justin, Rao, Mangala, Peachman, Kristina K., Santra, Sampa, Letvin, Norman L., Karasavvas, Nicos, Yang, Zhi-Yong, Dai, Kaifan, Pancera, Marie, Gorman, Jason, Wiehe, Kevin, Nicely, Nathan I., Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Kaewkungwal, Jaranit, Pitisuttithum, Punnee, Tartaglia, James, Sinangil, Faruk, Kim, Jerome H., Michael, Nelson L., Kepler, Thomas B., Kwong, Peter D., Mascola, John R., Nabel, Gary J., Pinter, Abraham, Zolla-Pazner, Susan, Haynes, Barton F.·2013·Immunity
DOI 10.1016/j.immuni.2012.11.011
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Abstract

Summary The RV144 HIV-1 trial of the canary pox vector (ALVAC-HIV) plus the gp120 AIDSVAX B/E vaccine demonstrated an estimated efficacy of 31%, that correlated directly with antibodies to HIV-1 envelope variable regions 1 and 2 (V1–V2). Genetic analysis of trial viruses revealed increased vaccine efficacy against viruses matching the vaccine strain at V2 residue 169. Here, we isolated four V2 monoclonal antibodies from RV144 vaccinees that recognize residue 169, neutralize laboratory-adapted HIV-1, and mediate killing of field isolate HIV-1-infected CD4+ T cells. Crystal structures of two of the V2 antibodies demonstrated residue 169 can exist within divergent helical and loop conformations, which contrasted dramatically with the beta strand conformation previously observed with a broadly neutralizing antibody PG9. Thus, RV144 vaccine-induced immune pressure appears to target a region that may be both sequence variable and structurally polymorphic. Variation may signal sites of HIV-1 envelope vulnerability, providing vaccine designers with new options.

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Metadata

Authors
Liao, H.-X., Bonsignori, M., Alam, S. M., McLellan, J. S., Tomaras, G. D., Moody, M. A., Kozink, D. M., Hwang, K.-K., Chen, X., Tsao, C.-Y., Liu, P., Lu, X., Parks, R. J., Montefiori, D. C., Ferrari, G., Pollara, J., Rao, M., Peachman, K. K., Santra, S., Letvin, N. L., Karasavvas, N., Yang, Z.-Y., Dai, K., Pancera, M., Gorman, J., Wiehe, K., Nicely, N. I., Rerks-Ngarm, S., Nitayaphan, S., Kaewkungwal, J., Pitisuttithum, P., Tartaglia, J., Sinangil, F., Kim, J. H., Michael, N. L., Kepler, T. B., Kwong, P. D., Mascola, J. R., Nabel, G. J., Pinter, A., Zolla-Pazner, S., & Haynes, B. F.
Venue
Immunity
Publisher
Elsevier BV
Published
2013-01
Volume
38
Issue
1
Pages
176-186
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2012.11.011
OpenAlex
W1985145726
Cited by
377
References
42
FWCI
24.65
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2. https://app.cochat.ai/papers/10.1016/j.immuni.2012.11.011
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Liao, H.-X., Bonsignori, M., Alam, S. M., McLellan, J. S., Tomaras, G. D., Moody, M. A., Kozink, D. M., Hwang, K.-K., Chen, X., Tsao, C.-Y., Liu, P., Lu, X., Parks, R. J., Montefiori, D. C., Ferrari, G., Pollara, J., Rao, M., Peachman, K. K., Santra, S., . . . Haynes, B. F. (2013). Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2. Immunity. https://doi.org/10.1016/j.immuni.2012.11.011

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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