The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors
Open accessAbstract
Summary Innate immunity conferred by the type I interferon is critical for antiviral defense. To date only a limited number of tripartite motif (TRIM) proteins has been implicated in modulation of innate immunity and anti-microbial activity. Here we report the cDNA cloning and systematic analysis of all known 75 human TRIMs. We demonstrate that surprisingly roughly half of the 75 TRIM-family members enhanced the innate immune response, and that they do this at multiple levels in signaling pathways. Moreover, mRNA levels and localization of most of these TRIMs were found to be altered during viral infection, suggesting that their regulatory activities are highly controlled at both pre- and post-transcriptional levels. Taken together, our data demonstrate a very considerable dedication of this large protein family to the positive regulation of the antiviral response, which supports the notion that this family of proteins evolved as a component of innate immunity.
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Cites
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Self-citationTRIM family proteins and their emerging roles in innate immunity
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TRIM5 is an innate immune sensor for the retrovirus capsid lattice
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Cited by
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis
Hatakeyama, S. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.01.002 · Cited by 960
Autophagy in inflammation, infection, and immunometabolism
Deretic, V. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.018 · Cited by 862
Viral RNA detection by RIG-I-like receptors
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Metadata
- Authors
- Versteeg, G. A., Rajsbaum, R., Sánchez-Aparicio, M. T., Maestre, A. M., Valdiviezo, J., Shi, M., Inn, K.-S., Fernandez-Sesma, A., Jung, J., & García-Sastre, A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 38
- Issue
- 2
- Pages
- 384-398
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2082429447
- Cited by
- 324
- References
- 38
- FWCI
- 14.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Versteeg, G. A., Rajsbaum, R., Sánchez-Aparicio, M. T., Maestre, A. M., Valdiviezo, J., Shi, M., Inn, K.-S., Fernandez-Sesma, A., Jung, J., & García-Sastre, A. (2013). The E3-Ligase TRIM Family of Proteins Regulates Signaling Pathways Triggered by Innate Immune Pattern-Recognition Receptors. Immunity. https://doi.org/10.1016/j.immuni.2012.11.013
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