The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

Croxford, Andrew L.; Lanzinger, Margit; Hartmann, Felix J.; Schreiner, Bettina; Mair, Florian; Pelczar, Pawel; Clausen, Björn E.; Jung, Steffen; Greter, Melanie; Becher, Burkhard

doi:10.1016/j.immuni.2015.08.010

The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation. Multiple cell types can sense GM-CSF, but the identity of the pathogenic GM-CSF-responsive cells is unclear. By using condit…