Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
Bengsch, Bertram, Johnson, Andy L., Kurachi, Makoto, Odorizzi, Pamela M., Pauken, Kristen E., Attanasio, John, Stelekati, Erietta, McLane, Laura M. +3 more·2016·Immunity
Cited by (867)
Items 301–400 of 867
- Long-term T cell fitness and proliferation is driven by AMPK-dependent regulation of reactive oxygen speciesAnouk Lepez, Tiphène Pirnay, Sébastien Denanglaire, David L. Pérez-Morga, Marjorie Vermeersch, Oberdan Léo, Fabienne Andris · 2020 · Scientific Reports
- Amino acids and RagD potentiate mTORC1 activation in CD8 + T cells to confer antitumor immunityYiwen Zhang, Hongrong Hu, Weiwei Liu, Shumei Yan, Yuzhuang Li, Likai Tan, Yingshi Chen, Jun Liu, Zhilin Peng, Yaochang Yuan et al. · 2021 · Journal for ImmunoTherapy of Cancer
- A novel strategy to fuel cancer immunotherapy: targeting glucose metabolism to remodel the tumor microenvironmentXu Liu, Yujie Zhao, Xi Wu, Zhihui Liu, Xiaowei Liu · 2022 · Frontiers in Oncology
- Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCTHajime Senjo, Shinpei Harada, Shimpei I. Kubota, Yuki Tanaka, Takahiro Tateno, Zixuan Zhang, Satomi Okada, Xuanzhong Chen, Ryo Kikuchi, Naoki Miyashita et al. · 2023 · Blood
- Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinomaFangming Liu, Weiren Liu, David E. Sanin, Guangshuai Jia, Meng‐Xin Tian, Han Wang, Bijun Zhu, Yan Lu, Tiankui Qiao, Xiangdong Wang et al. · 2020 · OncoImmunology
- T-cell Exhaustion in Organ TransplantationAndrea Angeletti, Chiara Cantarelli, Leonardo V. Riella, Miguel Fribourg, Paolo Cravedi · 2021 · Transplantation
- Metabolic Implications of Immune Checkpoint Proteins in CancerElizabeth R. Stirling, Steven M. Bronson, Jessica D. Mackert, Katherine Loree Cook, Pierre L. Triozzi, David R. Soto‐Pantoja · 2022 · Cells
- The effect of Wnt/β-catenin signaling on PD-1/PDL-1 axis in HPV-related cervical cancerParisa Shiri Aghbash, Nima Hemmat, Behzad Baradaran, Ahad Mokhtarzadeh, Vahdat Poortahmasebi, Mahin Ahangar Oskouee, Hossein Bannazadeh Baghi · 2022 · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis –induced immune toleranceAbhimanyu Abhimanyu, Santiago Carrero Longlax, Tomoki Nishiguchi, Malik Ladki, Daanish Sheikh, Amera L. Martinez, Emily Margaret Mace, Sandra L. Grimm, Thaleia Caldwell, Alexandra Portillo et al. · 2024 · Proceedings of the National Academy of Sciences
- TET2 regulates early and late transitions in exhausted CD8 + T cell differentiation and limits CAR T cell functionAlexander J. Dimitri, Amy E. Baxter, Gregory M. Chen, Caitlin R. Hopkins, Geoffrey T. Rouin, Hua Huang, Weimin Kong, Christopher Holliday, Volker Wiebking, Robert L. Bartoszek et al. · 2024 · Science Advances
- Metabolic reprogramming and apoptosis sensitivity: Defining the contours of a T cell responseKelsey Voss, Sasha E. Larsen, Andrew L. Snow · 2017 · Cancer Letters
- Targeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapyHelen Carrasco Hope, Robert J. Salmond · 2019 · European Journal of Immunology
- PD‐1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator‐activated receptor‐γBanu Batyrova, Fien Luwaert, Panagiota Maravelia, Yuria Miyabayashi, Neha Vashist, Julian M. Stark, Sara Y. Soori, Christopher Andrew Tibbitt, Peggy Riese, Jonathan M. Coquet et al. · 2019 · Immunity Inflammation and Disease
- Cutting edge: the regulatory mechanisms of macrophage polarization and function during pregnancyLiling Wang, Zhihui Li, Huan Wang, Joanne Y-H Kwak-Kim, Aihua Liao · 2022 · Journal of Reproductive Immunology
- Cellular Senescence in Immunity against InfectionsVeronica Marrella, Amanda Facoetti, Barbara Cassani · 2022 · International Journal of Molecular Sciences
- Metabolic regulation of infection and inflammationPrashant Singh Chauhan, Bhaskar Saha · 2018 · Cytokine
- Functional Restoration of Exhausted CD8 T Cells in Chronic HIV-1 Infection by Targeting Mitochondrial DysfunctionAljawharah Alrubayyi, Elia Moreno Cubero, Dan Hameiri‐Bowen, Rebecca Matthews, Sarah Rowland‐Jones, Anna Schurich, Dimitra Peppa · 2022 · Frontiers in Immunology
- Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomesPriyanka Nanjireddy, Scott H. Olejniczak, Nataliya Prokopenko Buxbaum · 2023 · Frontiers in Immunology
- Mitochondrial Metabolism in T-Cell ExhaustionFei Li, Feng Yu, Zesheng Yin, Y J Wang · 2025 · International Journal of Molecular Sciences
- Cell Intrinsic and Systemic Metabolism in Tumor Immunity and ImmunotherapyMichael F. Coleman, Alyssa Joy Cozzo, Alexander J. Pfeil, Suhas K. Etigunta, Stephen David Hursting · 2020 · Cancers
- Glucometabolic Reprogramming in the Hepatocellular Carcinoma Microenvironment: Cause and EffectHuining Tian, Xiaoyu Zhu, You Lv, Yan Jiao, Guixia Wang · 2020 · Cancer Management and Research
- The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against CancerAmmarina Beumer‐Chuwonpad, Renske L. R. E. Taggenbrock, T. An Ngo, Klaas P. J. M. van Gisbergen · 2021 · Cells
- YTHDF2 upregulation and subcellular localization dictate CD8 T cell polyfunctionality in anti-tumor immunityHaiyan Zhang, Xiao-Jing Luo, Wei Yang, Zhiying Wu, Zhicong Zhao, Xin Pei, Xue Zhang, Chonghao Chen, Josh Haipeng Lei, Qingxia Shi et al. · 2024 · Nature Communications
- The Metabolic Profile of Tumor and Virally Infected Cells Shapes Their Microenvironment Counteracting T Cell ImmunityIsabelle Magalhaes, Ohad Yogev, Jonas Mattsson, Anna Schurich · 2019 · Frontiers in Immunology
- Surveying the Metabolic and Dysfunctional Profiles of T Cells and NK Cells in Myalgic Encephalomyelitis/Chronic Fatigue SyndromeJessica Maya · 2023 · International Journal of Molecular Sciences
- NK-cell responses are biased towards CD16-mediated effector functions in chronic hepatitis B virus infectionAnita Schuch, Britta Franziska Zecher, Philipp Andreas Müller, Margareta P. Correia, Franziska Daul, Charlotte Rennert, Catrin Tauber, Karolin Schlitt, Tobias Boettler, Christoph Neumann‐Haefelin et al. · 2018 · Journal of Hepatology
- BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activityTaylor L. Hickman, Eugene Choi, Kathleen R. Whiteman, Sujatha Muralidharan, Tapasya Pai, Tyler Johnson, Avani Bharat Parikh, Taylor Friedman, Madaline Gilbert, Binzhang Shen et al. · 2022 · PLoS ONE
- Effects of PD-1 Signaling on Immunometabolic ReprogrammingVassiliki A. Boussiotis, Nikolaos Patsoukis · 2022 · Immunometabolism
- NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironmentJing Hao, Ruifeng Li, Xiaohong Zhao, Xinwei Liu, Xiang Chen, Tian Xie, Xiaoli Li, Chenjun Yao, Qinli Sun, Kun Wei et al. · 2024 · Cell Reports
- PPARβ/δ-orchestrated metabolic reprogramming supports the formation and maintenance of memory CD8 + T cellsAlessio Bevilacqua, Fabien Franco, Ya-Ting Lu, Nabil Rahiman, Kung‐Chi Kao, Yu‐Ming Chuang, Yanan Zhu, Werner Held, Xin Xie, Kristin C. Gunsalus et al. · 2024 · Science Immunology
- Immune Checkpoint Ligand Reverse Signaling: Looking Back to Go Forward in Cancer TherapyDaniele Lecis, Sabina Sangaletti, Mario P. Colombo, Claudia Chiodoni · 2019 · Cancers
- Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19Lichen Ouyang, Jie Gong · 2020 · Medical Hypotheses
- Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic ExhaustionBrian S. Koss, Bradley D. Shields, Erin M. Taylor, Aaron J. Storey, Stephanie D. Byrum, Allen J. Gies, Charity L. Washam, Samrat Roy Choudhury, Jeong Hyun Ahn, Hidetaka Uryu et al. · 2020 · Cancer Research
- NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancyEmma L. Lewis, Rong Xu, Jean‐Christophe Beltra, Shin Foong Ngiow, Jordana B. Cohen, Rahul Telange, Alexander Crane, Deirdre L. Sawinski, E. John Wherry, Paige M. Porrett · 2021 · The Journal of Experimental Medicine
- Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8 + T cellsFrances Winkler, Anna Veronika Hipp, Carlos Darío Ramírez, Bianca Martin, Matteo Villa, Emilia Neuwirt, Oliver Gorka, Jeroen Aerssens, Susanne E. Johansson, Nisha Rana et al. · 2023 · Gut
- Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responsesBrandon M. Oswald, Lisa M. DeCamp, Joseph Longo, Michael S. Dahabieh, Nicholas Bunda, Benjamin K. Johnson, McLane J. Watson, Shixin Ma, Samuel E.J. Preston, Ryan D. Sheldon et al. · 2025 · Nature Metabolism
- Mycoplasma bovis-Induced Inhibition of Bovine Peripheral Blood Mononuclear Cell Proliferation Is Ameliorated after Blocking the Immune-Inhibitory Programmed Death 1 ReceptorMuhammad Suleman, Farhan Sachal Cyprian, Steve Jimbo, Teresia Maina, Tracy Prysliak, M. Claire Windeyer, José Perez‐Casal · 2018 · Infection and Immunity
- Targeting Immunometabolism in GlioblastomaAditya A Mohan, William H. Tomaszewski, Aden Pepe Haskell-Mendoza, Kelly M. Hotchkiss, Kirit Singh, Jessica L. Reedy, Peter Edward Fecci, John Howard Sampson, Mustafa Khasraw · 2021 · Frontiers in Oncology
- Single-Cell Analyses Reveal the Metabolic Heterogeneity and Plasticity of the Tumor Microenvironment during Head and Neck Squamous Cell Carcinoma ProgressionXiaoyan Meng, Yang Zheng, Lingfang Zhang, Peipei Liu, Zhonglong Liu, Yue He · 2024 · Cancer Research
- Transient EZH2 Suppression by Tazemetostat during In Vitro Expansion Maintains T-Cell Stemness and Improves Adoptive T-Cell TherapyYingqin Hou, Jaroslav Žák, Yujie Shi, Isaraphorn Pratumchai, Brandon Dinner, Wenjian Wang, Ke Qin, Evan W. Weber, John Ross Teijaro, Peng Wu · 2024 · Cancer Immunology Research
- Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesisNicolaos Jay Palaskas, Jacob David Garcia, Roksana Shirazi, Daniel Sanghoon Shin, Cristina Puig-Saus, Daniel Braas, Antoni Ribas, Thomas G. Graeber · 2019 · Cell Discovery
- T Cell Metabolism in Cancer ImmunotherapyHalil‐Ibrahim Aksoylar, Natalia M. Tijaro-Ovalle, Vassiliki A. Boussiotis, Nikolaos Patsoukis · 2020 · Immunometabolism
- PPARγ induces PD-L1 expression in MSS+ colorectal cancer cellsTobias Gutting, Veronika Hauber, Jens H. W. Pahl, Kay Klapproth, Wenyue Wu, Ioana Dobrota, Frank Herweck, Juliane Reichling, Laura Helm, Torsten Schroeder et al. · 2021 · OncoImmunology
- Creatine in T Cell Antitumor Immunity and Cancer ImmunotherapyBo Li, Lili Yang · 2021 · Nutrients
- Autophagy inducer rapamycin treatment reduces IFN-I–mediated Inflammation and improves anti–HIV-1 T cell response in vivoWenli Mu, Valerie K. Rezek, Heather A. Martin, Mayra A. Carrillo, Shallu Tomer, Philip Hamid, Miguel A. Lizarraga, Tristan D. Tibbe, Otto O. Yang, Beth D. Jamieson et al. · 2021 · JCI Insight
- In Vitro Modeling of Tumor–Immune System InteractionChantal Mengus, Manuele Giuseppe Muraro, Valentina Mele, Francesca Amicarella, Celeste Manfredonia, Federica Foglietta, Simone E. Muenst, Savas Deniz Soysal, Giandomenica Iezzi, Giulio C. Spagnoli · 2017 · ACS Biomaterials Science & Engineering
- Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathwayCiputra Adijaya Hartana, Emma Ahlén Bergman, A. Ali Zirakzadeh, David Krantz, Malin Elisabeth Winerdal, Max Winerdal, Markus Johansson, Farhood Iranparvar Alamdari, Tomasz Jakubczyk, Hans Glise et al. · 2018 · PLoS ONE
- CAR-T treatment for cancer: prospects and challengesRan Chen, Lei Chen, Chaoqun Wang, Hua Zhu, Lijuan Gu, Yuntao Li, Xiaoxing Xiong, Gang Chen, Zhihong Jian · 2023 · Frontiers in Oncology
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapyZeyu Chen, Ziang Zhu, Taidou Hu, Chen Yao, Tuoqi Wu · 2025 · Cellular and Molecular Immunology
- Complement C1q binding protein regulates T cells’ mitochondrial fitness to affect their survival, proliferation, and anti–tumor immune functionHui Tian, Gang Wang, Qiping Wang, Bao-Fu Zhang, G. Jiang, Hui-Zhong Li, Dafei Chai, Lin Fang, Meng Wang, Jun-Nian Zheng · 2022 · Cancer Science
- Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1DPeter S. Linsley, Sarah Alice Long · 2019 · Current Opinion in Endocrinology Diabetes and Obesity
- A narrative review of immune checkpoint mechanisms and current immune checkpoint therapySiqi Peng, Yifeng Bao · 2021 · Annals of Blood
- Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamusYukari Suda, Toshihisa Nakashima, Hiroaki Matsumoto, Daisuke Sato, Satoshi Nagano, Haruka Mikata, Sara Yoshida, Kenichi Tanaka, Yusuke Hamada, Naoko Kuzumaki et al. · 2021 · Biochemical and Biophysical Research Communications
- Epigenetic Features of HIV-Induced T-Cell Exhaustion Persist Despite Early Antiretroviral TherapyGenevieve Elizabeth Martin, Debattama R. Sen, Matthew J. Pace, Nicola Robinson, Jodi Meyerowitz, Emily Adland, John Patrick Thornhill, Mathew Jones, Ane Ogbe, Lucia Parolini et al. · 2021 · Frontiers in Immunology
- Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector MoleculesMarlies J. W. Peeters, Pia Aehnlich, Adriano Pizzella, Kasper Mølgaard, Tina Seremet, Özcan Met, Lene Juel Rasmussen, Per thor Straten, Claus Desler · 2021 · Frontiers in Immunology
- P2RX7 Enhances Tumor Control by CD8+ T Cells in Adoptive Cell TherapyKelsey Marie Wanhainen, Changwei Peng, Maggie H. Zhou, Bruna de Gois Macedo, Stephen D. O’Flanagan, Tingyuan Yang, Ameeta Kelekar, Brandon J. Burbach, Henrique Borges da Silva, Stephen C. Jameson · 2022 · Cancer Immunology Research
- PET Radiomics and Response to Immunotherapy in Lung Cancer: A Systematic Review of the LiteratureLaura Evangelista, Francesco Fiz, Riccardo Laudicella, Francesco Bianconi, Angelo Castello, Priscilla Guglielmo, Virginia Liberini, Luigi Manco, Viviana Frantellizzi, Alessia Giordano et al. · 2023 · Cancers
- Early Inhibition of Fatty Acid Synthesis Reduces Generation of Memory Precursor Effector T Cells in Chronic InfectionSamad A. Ibitokou, Brian Dillon, Mala Sinha, Bartosz Szczęsny, Anahi De Jesus Delgadillo, Doaa Reda Abdelrahman, Csaba Szabó, Lutfi A. Abu-Elheiga, Craig C. Porter, Demidmaa Tuvdendorj et al. · 2017 · The Journal of Immunology
- IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infectionElia Moreno Cubero, Aljawharah Alrubayyi, Stefan Balint, Ane Ogbe, Upkar S. Gill, Rebecca Matthews, Sabine Kinloch‐de Loes, Fiona M. Burns, Sarah Rowland‐Jones, Persephone Borrow et al. · 2024 · JCI Insight
- Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infectionAKM Nur-ur Rahman, Jun Liu, Shariq Mujib, Segen Kidane, Arman Ali, Steven Szep, Carrie Han, Phil Bonner, Michael Parsons, Erika Benko et al. · 2021 · Life Science Alliance
- Lysosomes in T Cell Immunity and AgingJun Jin, Huimin Zhang, Cornelia M. Weyand, Jörg J. Goronzy · 2021 · Frontiers in Aging
- Innate and Adaptive Immune Cell Metabolism in Tumor MicroenvironmentDuojiao Wu · 2017 · Advances in experimental medicine and biology
- The adaptation of SARS-CoV-2 to humansEduardo Tosta · 2021 · Memórias do Instituto Oswaldo Cruz
- CD8+ T cell stemness precedes post-intervention control of HIV viraemiaZahra Kiani, Jonathan M. Urbach, Hannah Wisner, Mpho J. Olatotse, Daniel Y. Chang, Joshua A. Acklin, Alicja K. Trocha, Nathalie Bonheur, Ashok Khatri, Mathias D. Lichterfeld et al. · 2025 · Nature
- MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infectionErietta Stelekati, Zhangying Cai, Sasikanth Manne, Zeyu Chen, Jean‐Christophe Beltra, Lance Alec Buchness, Xuebing Leng, Svetlana Ristin, Kito Nzingha, Viktoriya Ekshyyan et al. · 2022 · Proceedings of the National Academy of Sciences
- Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in people living with HIVMarta Calvet‐Mirabent, Ildefonso Sánchez‐Cerrillo, Noa Beatriz Martin-Cofreces, Pedro Martínez‐Fleta, Hortensia de la Fuente, Ilya Tsukalov, Cristina Delgado‐Arévalo, María José Calzada, Ignacio de los Santos, Jesús Sanz et al. · 2022 · EBioMedicine
- Exhaustion of CD39-Expressing CD8+ T Cells in Crohn’s Disease Is Linked to Clinical OutcomeAnna-Maria Globig, L Mayer, Maximilian Heeg, Geoffroy Andrieux, Manching Ku, Patricia Otto-Mora, Anna Veronika Hipp, Katharina Zoldan, Ajinkya Pattekar, Nisha Rana et al. · 2022 · Gastroenterology
- Regulatory Mechanisms and Reversal of CD8+T Cell Exhaustion: A Literature ReviewWanwan Zhu, Yiming Li, Mingwei Han, Jian‐Li Jiang · 2023 · Biology
- CBX4 suppresses CD8 + T cell antitumor immunity by reprogramming glycolytic metabolismJingzeng Wang, Wenlong Jia, Xi Kathy Zhou, Zhibo Ma, Jing Liu, Peixiang Lan · 2024 · Theranostics
- Harnessing CD8+ T cell dynamics in hepatitis B virus‐associated liver diseases: Insights, therapies and future directionsBing Yue, Yuxia Gao, Yi Hu, Meixiao Zhan, Yangzhe Wu, Ligong Lu · 2024 · Clinical and Translational Medicine
- Pathophysiology and preclinical relevance of experimental graft-versus-host disease in humanized miceGrégory Ehx, Caroline Ritacco, Frédéric Baron · 2024 · Biomarker Research
- Reversing the mitochondrial stress-induced exhaustion of CD8+ T cells for improving cancer immunotherapyCheng Qian, Xuetao Cao · 2021 · Cellular and Molecular Immunology
- Importance of T, NK, CAR T and CAR NK Cell Metabolic Fitness for Effective Anti-Cancer Therapy: A Continuous Learning Process Allowing the Optimization of T, NK and CAR-Based Anti-Cancer TherapiesAdrien Krug, Adriana Martinez-Turtos, Els Verhoeyen · 2021 · Cancers
- Impact of Drp1-Mediated Mitochondrial Dynamics on T Cell Immune ModulationJun Song, Xiaofang Yi, Ruo-Lin Gao, Li Sun, Zhixuan Wu, Shuling Zhang, Le‐Tian Huang, Cheng‐Bo Han, Jie‐Tao Ma · 2022 · Frontiers in Immunology
- A single-cell atlas of CD19 chimeric antigen receptor T cellsXubin Li, Jared M. Henderson, Max J. Gordon, Irtiza N. Sheikh, Loretta J. Nastoupil, Jason R. Westin, Christopher R. Flowers, Sairah Ahmed, Linghua Wang, Sattva Swarup Neelapu et al. · 2023 · Cancer Cell
- Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long HaulGreg M. Delgoffe · 2016 · Cancer Immunology Research
- CD8+ T-cell exhaustion: Impediment to triple-negative breast cancer (TNBC) immunotherapy.Dandan Feng, Dong-Qing Pu, Jinlu Ren, Ming Liu, Zhen Zhang, Zhiyong Liu, Jing-Wei Li · 2024 · Biochimica et biophysica acta. Reviews on cancer
- Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunityJoanne D. Tejero, Rebecca S. Hesterberg, Stanislav Drápela, Didem Ilter, Devesh Raizada, Felicia Lazure, Hossein Kashfi, Min Liu, Leonardo Silvane, Dorina Avram et al. · 2024 · Oncogene
- Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustionMumtaz Yaseen Balkhi · 2020 · OncoImmunology
- New Immuno-oncology Targets and Resistance MechanismsMolly C. Tokaz, Christina S. Baik, A. McGarry Houghton, Diane Tseng · 2022 · Current Treatment Options in Oncology
- Type 1 diabetes pathogenesis and the role of inhibitory receptors in islet toleranceTijana Martinov, Brian T. Fife · 2019 · Annals of the New York Academy of Sciences
- T cell exhaustion and senescence for ovarian cancer immunotherapyJiao Zhao, Zhongmiao Wang, Yingying Tian, Jing Ning, Huinan Ye · 2024 · Seminars in Cancer Biology
- The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivationZiang Zhu, Ying Luo, Guohua Lou, Kiddist D. Yihunie, Safuwra Wizzard, Andrew DeVilbiss, Sarah Muh, Chaoyu Ma, Sejal S. Shinde, Jonathan Hoar et al. · 2024 · Science Immunology
- The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8+ T cell exhaustionMichael S. Dahabieh, Lisa M. DeCamp, Brandon M. Oswald, Susan M. Kitchen-Goosen, Zhen Fang Fu, Matthew Vos, Shelby E. Compton, Joseph Longo, Nicole M Foy, Kelsey S. Williams et al. · 2025 · Nature Immunology
- Immune Modulation in Lung Cancer: Current Concepts and Future StrategiesLena Gaissmaier, Petros Christopoulos · 2020 · Respiration
- Yangyin Fuzheng Jiedu Prescription exerts anti-tumor immunity in hepatocellular carcinoma by alleviating exhausted T cellsFengna Yan, Xinhui Wang, Yuqing Xie, Xiaoli Liu, Lihua Yu, Peng Wang, Tenghui Li, Shanshan Wang, Weihong Li, Zhiyun Yang · 2021 · Phytomedicine
- Transcriptional coactivator PGC-1α contributes to decidualization by forming a histone-modifying complex with C/EBPβ and p300Haruka Takagi, Isao Tamura, Taishi Fujimura, Yumiko Doi‐Tanaka, Yuichiro Shirafuta, Yumiko Mihara, Ryo Maekawa, Toshiaki Taketani, Shun Sato, Hiroshi Tamura et al. · 2022 · Journal of Biological Chemistry
- Toward innovative combinational immunotherapy: A systems biology perspectiveXuetao Li, Jin‐Ji Yang, Yi-Long Lung Cancer Wu, Jun Hou · 2018 · Cancer Treatment Reviews
- Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatmentJohn J. Wilson, Jian Qin Wei, Andrea R. Daamen, John D. Sears, Elaine Bechtel, Colleen L. Mayberry, Grace A. Stafford, Lesley S. Bechtold, Amrie C. Grammer, Peter E. Lipsky et al. · 2023 · iScience
- Molecular insight into T cell exhaustion in hepatocellular carcinomaYonghua Zhu, Huabing Tan, Jincheng Wang, Haiwen Zhuang, Huanbin Zhao, Xiaojie Lu · 2024 · Pharmacological Research
- T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic OpportunitiesYu Pu Yang, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun · 2026 · Advanced Science
- Translating In Vitro T Cell Metabolic Findings to In Vivo Tumor Models of Nutrient CompetitionChristopher Ecker, James L. Riley · 2018 · Cell Metabolism
- Apoptotic bodies inhibit inflammation by PDL1–PD1 ‐mediated macrophage metabolic reprogrammingTao Jiang, Yanmin Xia, Wenzhe Wang, Jinbo Zhao, Wenhao Liu, Shiyu Liu, Songtao Shi, Bei Li, Xiaoning He, Yan J. Jin · 2023 · Cell Proliferation
- Aging of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue HomingBennett Davenport, Jens Eberlein, Verena van der Heide, Kevin Jhun, Tom T. Nguyen, Francisco Victorino, Andrew Paul Trotta, Jerry E. Chipuk, Zhengzi Yi, Weijia Zhang et al. · 2018 · The Journal of Immunology
- How host metabolism impacts on virus pathogenesisSiva Karthik Varanasi, Barry T. Rouse · 2017 · Current Opinion in Virology
- Nicotinamide Inhibits T Cell Exhaustion and Increases Differentiation of CD8 Effector T CellsSara Alavi, Abdullah Al Emran, Hsin‐Yi Tseng, Jessamy C. Tiffen, Helen Marie McGuire, Peter Hersey · 2022 · Cancers
- Phenotypic, functional, and metabolic heterogeneity of immune cells infiltrating non–small cell lung cancerBeatrice Aramini, Valentina Masciale, Anna Valeria Samarelli, Alessandra Dubini, Michele Gaudio, Franco Stella, Uliano Morandi, Massimo Dominici, Sara De Biasi, Lara Gibellini et al. · 2022 · Frontiers in Immunology
- Metabolism heterogeneity in melanoma fuels deactivation of immunotherapy: Predict before protectXinyue Zhang, Zongguang Tai, Fengze Miao, Hao Huang, Quangang Zhu, Leilei Bao, Zhongjian Chen · 2022 · Frontiers in Oncology
- Altered Fatty Acid Oxidation in Lymphocyte Populations of Myalgic Encephalomyelitis/Chronic Fatigue SyndromeJessica Maya, Sabrina M. Leddy, Carl Gunnar Gottschalk, Daniel L. Peterson, Maureen R. Hanson · 2023 · International Journal of Molecular Sciences
- 18F-FAC PET Selectively Images Liver-Infiltrating CD4 and CD8 T Cells in a Mouse Model of Autoimmune HepatitisJessica R. Salas, Bao Ying Chen, Alicia Wong, Donghui Cheng, John S. Van Arnam, Owen N. Witte, Peter M. Clark · 2018 · Journal of Nuclear Medicine