Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA

Zhang, Zhikuan, Ohto, Umeharu, Shibata, Takuma, Krayukhina, Elena, Taoka, Masato, Yamauchi, Yoshio, Tanji, Hiromi, Isobe, Toshiaki +3 more·2016·Immunity

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Items 101–200 of 476

  1. Sequence-Specific Sensing of Nucleic Acids
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  3. Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9
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  5. Discrimination Between Self and Non-Self-Nucleic Acids by the Innate Immune System
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  6. Structural Evolution and Translational Potential for Agonists and Antagonists of Endosomal Toll-like Receptors
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  11. The tRNA Val half: A strong endogenous Toll-like receptor 7 ligand with a 5′-terminal universal sequence signature
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  12. DNA-based fluorescent probes of NOS2 activity in live brains
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  13. Toward a structural understanding of nucleic acid‐sensing Toll‐like receptors in the innate immune system
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  14. Integrative Structural Biology of Protein-RNA Complexes
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  15. Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies
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  16. The crosstalk between viral RNA- and DNA-sensing mechanisms
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  18. Shaping the Innate Immune Response Through Post-Transcriptional Regulation of Gene Expression Mediated by RNA-Binding Proteins
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  52. Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer
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  53. Recent trends in the development of Toll-like receptor 7/8-targeting therapeutics
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  54. A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza
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