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Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution
Open accessAbstract
Regulatory T (Treg) cell responses and apoptotic cell clearance (efferocytosis) represent critical arms of the inflammation resolution response. We sought to determine whether these processes might be linked through Treg-cell-mediated enhancement of efferocytosis. In zymosan-induced peritonitis and lipopolysaccharide-induced lung injury, Treg cells increased early in resolution, and Treg cell depletion decreased efferocytosis. In advanced atherosclerosis, where defective efferocytosis drives disease progression, Treg cell expansion improved efferocytosis. Mechanistic studies revealed the following sequence: (1) Treg cells secreted interleukin-13 (IL-13), which stimulated IL-10 production in macrophages; (2) autocrine-paracrine signaling by IL-10 induced Vav1 in macrophages; and (3) Vav1 activated Rac1 to promote apoptotic cell engulfment. In summary, Treg cells promote macrophage efferocytosis during inflammation resolution via a transcellular signaling pathway that enhances apoptotic cell internalization. These findings suggest an expanded role of Treg cells in inflammation resolution and provide a mechanistic basis for Treg-cell-enhancement strategies for non-resolving inflammatory diseases.
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In the citing paper
“They contribute to the control and termination of the inflammatory response by producing anti‐inflammatory cytokines such as IL‐10, TGF‐β, and IL‐35.[ 9 ]”
From Ccl2-Induced Regulatory T Cells Balance Inflammation Through Macrophage Polarization During Liver Reconstitution (2024) · cites this paper as [9]
Experimental — accuracy not yet measuredIn the citing paper
“and new work indicates that a cellular pathway of the inflammation resolution response — mediated by regulatory T cells — also promotes efferocytosis79.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [79]
In the citing paper
“The mechanism of the regulatory T cell response involves secretion of IL-13, which in turn stimulates macrophages to secrete and then be activated by the pro-efferocytic cytokine IL-10 (REF79).”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [79]
In the citing paper
“The impaired ability of macrophage efferocytosis would enhance atherogenesis [139,140,141] and atherosclerotic plaque instability [142,143,144].”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [139]
In the citing paper
“The elevated IL-10 signaling upregulates macrophage STAT3-mediated VAV1 (a guanine nucleotide exchange factor), which activates GTPase Rac1 to enhance apoptotic cell engulfment by macrophages [139].”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [139]
In the citing paper
“activated Treg cells secrete IL-13 to stimulate IL-10 production in macrophages via binding to the IL-13 receptor.”
From Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases (2020) · cites this paper as [139]
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Cites
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890
Chen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,730
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166 · cited 1×
“Moreover, signaling through certain efferocytosis receptors can inhibit inflammatory signaling pathways and promote the secretion of resolution mediators (Fadok et al., 1998; Freire-de-Lima et al., 2006; Cai et al., 2016).”
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M. G., Langford, T. K. A., Bucks, C. M., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 2,079
Matute‐Bello, G., Downey, G. P., Moore, B. B., Groshong, S. D., Matthay, M. A., Slutsky, A. S., & Kuebler, W. M. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0210st · Cited by 2,016
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages
Ip, W., Hoshi, N., Shouval, D. S., Snapper, S. B., & Medzhitov, R. M. (2017) · Science · doi:10.1126/science.aal3535 · Cited by 1,382
Natural regulatory T cells control the development of atherosclerosis in mice
Ait‐Oufella, H., Salomon, B. L., Potteaux, S., Robertson, A.-K. L., Gourdy, P., Zoll, J., Merval, R., Esposito, B., Cohen, J. L., Fisson, S., et al. (2006) · Nature Medicine · doi:10.1038/nm1343 · Cited by 1,126
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization
Schust, J., Sperl, B., Hollis, A., Mayer, T. U., & Berg, T. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.09.018 · Cited by 1,105
Sutmuller, R. P. M., van Duivenvoorde, L. M., van Elsas, A., Schumacher, T. N. M., Wildenberg, M. E., Allison, J. P., Toes, R. E. M., Offringa, R., & Melief, C. J. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.823 · Cited by 1,008
A Distinct Function of Regulatory T Cells in Tissue Protection
Arpaia, N., Green, J. A., Moltedo, B., Arvey, A., Hemmers, S., Yuan, S., Treuting, P. M., & Rudensky, A. Y. (2015) · Cell · doi:10.1016/j.cell.2015.08.021 · Cited by 991
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Items 301–400 of 443
Bashir, S. M., Rizk, S. M., Nooh, M. M., & Helmy, H. S. (2024) · Inflammation · doi:10.1007/s10753-024-02150-y · Cited by 5
“Treg cells could stimulate macrophages producing IL-10 by secreting IL-13 [78].”
Nwabufo, C. K., Luc, J., McGeer, A., Hirota, J. A., Mubareka, S., Doxey, A. C., & Moraes, T. J. (2024) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.16124 · Cited by 5
“8,44 Transcriptional activators such as peroxisome proliferator-activated receptor-α (PPAR α ) and hepatocyte nuclear factor-1 α can also induce the expression of DMETs.”
Maimaitiyiming, A., An, H., Chen, X., Li, X., Zhao, L., Bai, J., Luo, C., Zhuo, T., Huang, X., Maimaiti, A., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35157 · Cited by 5
“During the resolution of inflammation, regulatory T (Treg) cells secrete IL13, promoting the efflux of macrophages and enhancing the engulfment of apoptotic cells [64].”
BackgroundMacrophage efferocytosis is controlled by epigenetic modifications mediated by RBPJPreprint
Sadaf, S., Zhang, X., Lei, L., Shen, J., Jamal, I., Modugu, G., & Dutta, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.10.681723 · Cited by 8
Bao, X., Dun, Y., Hu, H., Tang, Y., Liu, F., Zhou, J., & Shen, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114968 · Cited by 4
Building blocks for lung regeneration: Stem cells and niches
Lee, H., Lim, C. W., Lee, W. R., Park, J. E., Yu, D. Y., & Choi, J. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100241 · Cited by 4
Zhang, X., Cao, M., Fu, S., Wang, J., Ong, M. T., & Yung, P. S. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.108041 · Cited by 4
Artery Tertiary Lymphoid Organs Form Neuroimmune Cardiovascular Interfaces in Atherosclerosis
Mohanta, S. K., Hong, M., Deng, X., Dou, X., Xu, X., Monjezi, M. R., Li, Y., Sun, T., Wang, Z., Habenicht, A. J. R., et al. (2026) · Immunological Reviews · doi:10.1111/imr.70106 · Cited by 5
Orchestrated regulation of immune inflammation with cell therapy in pediatric acute liver injury
Duan, M., Liu, X., Yang, Y., Zhang, Y., Wu, R., Lv, Y., & Lei, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1194588 · Cited by 4
Impaired CAMK4 Activity Limits Atherosclerosis and Reprograms Myelopoiesis
Gonzalez, A. L., Youwakim, C. M., Leake, B. F., Fuller, K., Rahman, S. M. J., Dungan, M. M., Gu, K., Bonin, J. L., Cavnar, A. B., Michell, D. L., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.322530 · Cited by 4
Self-citationSagar, K., Akhtar, S., Kumar, N., Tomar, A. K., Roy, A., Hote, M. P., Arava, S., Yadav, S., & Sharma, A. (2025) · Immunology · doi:10.1111/imm.13941 · Cited by 4
“Further, Tregs are known to increase macrophage efferocytosis during inflammation resolution in atherosclerosis [10].”
Excision of mesenteric lymph nodes alters gut microbiota and impairs social dominance in adult mice
Yang, R., Huang, B., Wang, Y., Meng, Q., Guo, Y. C., Wang, S., Yin, X., Feng, H., Gong, M., Wang, S., et al. (2023) · Brain and Behavior · doi:10.1002/brb3.3053 · Cited by 3
“Meanwhile, Treg promotes the production of interleukin (IL) 10—an anti-inflammatory cytokine—which is essential to reduce inflammation and protect the functions of the central nervous system (CNS) (Böhmet al., 2015; Proto et al., 2018).”
BackgroundPan, Q., Chen, C., & Yang, Y. (2023) · Current Medical Science · doi:10.1007/s11596-023-2818-2 · Cited by 4
Mccullough, M., Bose, P. G., & Mock, J. R. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106568 · Cited by 6
Jeon, E., Seo, M.-S., Lkhagva‐Yondon, E., Lim, Y., Kim, S.-W., Kang, Y. J., Lee, J. S., Lee, B. D., Wi, R., Won, S.-Y., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07252-x · Cited by 4
Wang, T., Chen, S., Zhou, D., & Hong, Z. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156148 · Cited by 7
Ramji, D. P., Ismail, A., Chen, J., Alradi, F., & Alalawi, S. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1924-7_3 · Cited by 4
Alveolar Macrophages during Inflammation: A Balancing Act
Poor, T. A., & Morales‐Nebreda, L. (2023) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0098ed · Cited by 4
Scolaro, B., Brown, E. J., Krautter, F., Petitjean, M., Donahoe, C., Pena, S., Garabedian, M. L., Nikain, C. A., Laskou, M., Tufanlı, Ö., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.07.539777 · Cited by 4
Yuan, D., Zheng, Z., Shen, C., Ye, J., & Zhu, L. (2024) · Molecular Immunology · doi:10.1016/j.molimm.2024.01.002 · Cited by 3
Chen, J., Zheng, C., Zhang, F., Sun, S., Liu, G., & Huang, G. C. (2025) · Discover Oncology · doi:10.1007/s12672-025-02961-x · Cited by 3
“Efferocytosis also promotes inflammation resolution by increasing anti-inflammatory mediator secretion and activating repair-associated transcriptional programs [29].”
Visceral adipose tissue regulatory T cells: A potential new target for treating atherosclerosis
Huang, S., Huang, F., Yi, C., Zhang, W., Guo, L., Xia, T., Chen, Y., Yang, Y., Tian, W., Li, H., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177998 · Cited by 3
Bao, X., Hu, H., Dun, Y., Tang, Y., Liu, F., Zhou, J., Mo, W., & Shen, J. (2025) · Respiratory Research · doi:10.1186/s12931-025-03343-1 · Cited by 3
“After incubating in Ham’s F-12 K medium containing 10% fetal bovine serum for 3 h, the plate was gently washed with PBS, and the adherent cells were used for the ex vivo effe-rocytosis assay [24].”
Huang, Y.-P., Chien, C., Wang, L., & Chiang, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-19445-1 · Cited by 3
“As reported previously, IL-13 derived from Treg cells can induce IL-10 production in macrophages 18, which might explain the synergistic effects observed between IL-10 and IL-13.”
Heterogeneity of Lung Phagocytes and Clearance of Apoptotic Cells in Lung Injury and Repair
Bersie, S. M., & McCubbrey, A. L. (2025) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/a-2675-2564 · Cited by 3
Immunopathogenesis of Acute Pancreatitis
Булава, Г. В. (2022) · Russian Sklifosovsky Journal Emergency Medical Care · doi:10.23934/2223-9022-2022-11-3-484-492 · Cited by 3
Beebe, K. D., Eisner, J. R., Guo, Y., Shibata, Y., Davison, J. M., Uronis, J., Farhangfar, C. J., Farhangfar, F., Mooney, J. M., Milburn, M. V., et al. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300736 · Cited by 3
Liu, W.-X., Hu, Y., Tai, G., Li, Y., Li, J., Qiu, S., Zheng, R., Damdinjav, D., Otieno, J. N., Li, X.-X., et al. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118556 · Cited by 3
Shen, Y., Xu, H., Long, M., Guo, M., Li, P., Zhan, M., & Wang, Z. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.761643 · Cited by 3
Song, Z.-Q., Chen, Y., Yu, T., Xu, Y.-P., Chen, Z., Lu, X., Chen, Z.-Y., Wang, C.-Y., Zhang, M., Chen, R., et al. (2025) · Heart Lung and Circulation · doi:10.1016/j.hlc.2024.10.016 · Cited by 2
Immune cells in liver regeneration: Current evidence and potential clinical targets
Moore, H. F., Usmani, S., Froghi, S., Rashidi, H., Quaglia, A., Fuller, B. J., & Davidson, B. R. (2025) · International Reviews of Immunology · doi:10.1080/08830185.2025.2531820 · Cited by 4
“Moreover, IL-10 production by Tregs enhances MDM efferocytosis in the resolution phase of liver regeneration [286].”
Vernay, E., Cerrato, E., Santinon, F., Monard, C., Perez, P., Allantaz, F., Lukaszewicz, A., & Llitjos, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1627313 · Cited by 3
Lin, M., Li, W. X., Wu, Y., Li, M., Li, Y., & Zhao, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1776040 · Cited by 2
Liu, Z., Lai, H., Yang, Q., Zhang, C., Jia, B., Chen, Q., Deng, Y., Cao, F., You, Y., Li, Z., et al. (2026) · Advanced Science · doi:10.1002/advs.202521458 · Cited by 2
“…proteins including arginase-1 (ARG1) [ 8 ], vascular endothelial growth factor (VEGF) [ 9, 10 ], and various cytokines (IL10, TGF-β , etc.) [ 11 ] are essential in shaping monocytes toward the immunosuppressive phenotype, emerging evidence highlights the importance of deregulated metabolic…”
The Changing Face of Atherosclerosis
Meiliana, A., & Wijaya, A. (2023) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v15i3.2347 · Cited by 2
“(139) It's interesting to note that during atherosclerosis, IL-13 encourages additional resolving activities, such as boosting the formation of lesional collagen, decreasing monocyte recruitment, and shifting macrophages towards a pro-resolving phenotype.”
BackgroundQi, Y., Zhang, Y., Guan, S., Liu, L., Wang, H., Chen, Y., Zhou, Q., Xu, F., & Zhang, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1381229 · Cited by 2
Establish TIIC signature score based the machine learning fusion in bladder cancer
Zeng, X., Lu, Z., Dai, C., Su, H., Liu, Z., & Cheng, S. (2024) · Discover Oncology · doi:10.1007/s12672-024-01187-7 · Cited by 2
Li, T., Liu, Y., Fu, J., Huang, L., & Liu, Z. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1430477 · Cited by 2
Zheng, F., Zhang, X., Wang, S., Jia, G., & Cheng, L. (2025) · Biomedicines · doi:10.3390/biomedicines13061294 · Cited by 2
Type 2 Inflammation: A Potential Clinical Link Between Asthma and Cardiovascular Diseases
Yang, Z., Ge, Y., Zuo, R., Wang, J., Wang, W., Shao, C., Chang, C. J., & Tang, Y. (2025) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2025.0014 · Cited by 2
“IL-13, derived from activated T-regulatory (Treg) cells, induces IL-10 secretion and enhances efferocytosis by macrophages, thereby controlling atherosclerosis progression [28].”
Liu, Y., Wu, K., Yang, X., Zhang, X., Xiao, Y., Zhou, C., Zhu, Y. Z., Guo, H., & Wang, X. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168614 · Cited by 2
Cenabis Bene: Treg Cells Invite Macrophages to Dine
Hughes, L. D., Ghosh, S., & Rothlin, C. V. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.002 · Cited by 2
Lv, H., Hua, Q., Wang, Y., Gao, Z., Liu, P., Qin, D., & Xu, Y. (2023) · PubMed Central · Cited by 2
Iqbal, H., & Rhee, D. (2024) · Vaccines · doi:10.3390/vaccines12070737 · Cited by 1
Genes and pathways of regulatory T cells regulated by adenosine A2A receptor: A bioinformatics study
Wang, D., Wang, J., & Zheng, X. (2021) · All Life · doi:10.1080/26895293.2021.1999861 · Cited by 2
T Regulatory Mechanisms in Airway and Interstitial Lung Disease
Pastore, C., Stadler, B. D., Sperling, A. I., & Velez, T. E. (2025) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/a-2703-4491 · Cited by 2
Wei, L., Wen, S., Dang, T., Zeng, T., Yang, S., You, Y., Tang, J., Sun, H., Zhang, L., Li, Q., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-22816-3 · Cited by 1
“Efferocytosis, the phagocytic clearance of apoptotic cells, exhibits both anti-inflammatory and pro-tumor effects 25,26 .”
Wang, J., Li, Z., Wang, Z., Liang, W., Meng, S., Chen, J.-F., Wang, J., Zhang, J., & Lin, B. (2025) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szaf058 · Cited by 3
Yang, J., Xue, J., Mo, L., Zhang, A., Xie, J., Fan, J., Zhong, J., Han, H., Yang, P., Liu, D., et al. (2025) · Immunology · doi:10.1111/imm.70078 · Cited by 2
“Exosomes from liposome-trained DCs, enriched in PD-L1 (2.5×) and TGF-β1 (2.0×), suggest paracrine amplification of Treg induction and effector T cell suppression [22].”
InfluentialExosomal LINC01614 from Gastric Cancer Cells Drives Treg Differentiation
He, N., Ruan, D.-J., Zhang, N., Wang, B., Zhong, Y., Li, K. F. N., Yin, S., & Yang, X. (2026) · Journal of Visualized Experiments · doi:10.3791/69218 · Cited by 1
Targeting inflammation in atherosclerosis: prospects and limitations
Tanyanskiy, D. A., Denisenko, A. D., & Pigarevsky, P. V. (2025) · Cytokines and inflammation · doi:10.17816/ci699662 · Cited by 1
“IL-10 promote efferocytosis [49], which is important for removing excess cholesterol from the vessel wall during atherogenesis.”
Advances in understanding mitophagy's role in lung injury
Du, W., Yang, Y., Zhang, T., Jiang, J., Du, D., Huang, G., & Tao, S. (2026) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2025.06.004 · Cited by 1
“85,86 Additionally, regulatory T cells can modulate macrophage polarization, with mitophagy playing a contributory role.”
Macrophage MERTK restrains GRAMD1A-driven mitochondrial oxysterol trafficking to limit colitis
Liu, J., Liu, P., Li, Y., Zheng, T., Wu, C., Gong, W., Li, Z., Qu, G., Li, X., Yang, Y., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104174 · Cited by 1
“Several studies [3,4] have shown that enhancing intestinal efferocytosis mitigates tissue inflammation.”
Fu, Z., Wu, J., Zhang, S., Jiao, J., Hong, Q., Wang, Y., Zheng, L., Qu, X., & Yue, B. (2026) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2026.101143 · Cited by 1
Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies
Lei, Y., Tang, M., Deng, H., Li, Y., Wu, J., Luo, L., Mou, Y., 吴千石, Li, Q., Xu, Y., et al. (2026) · Inflammation Research · doi:10.1007/s00011-026-02302-w · Cited by 1
“Beyond its basic function of clearing apoptotic cells, this process serves as a critical regulator of inflammation resolution, macrophage programming, and immune tolerance [10, 46–48].”
Thome, A. D., Wang, J., Faridar, A., Zhao, W., Saetzler, V., Beers, D. R., & Appel, S. H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177855 · Cited by 1
“Conversely, inadequate Treg-mediated control can permit continued myeloid activation and inflammatory amplification, while effective Treg regulation can directly restrain inflammatory myeloid programs [82,83].”
Vlachogiannis, N. I., Legaki, A., & Chatzigeorgiou, A. (2022) · Clinical and Translational Discovery · doi:10.1002/ctd2.94 · Cited by 1
Influence of Immune and Inflammatory Effects on the Pathogenesis of Coronary Artery Disease
李, 霜. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.133410 · Cited by 1
Li, S., Bai, Z., Quan, J., & Chen, C. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.15.35 · Cited by 1
“It has also been found in other cardiovascular diseases that targeted therapy of regulatory T cells may provide new methods and directions for the prevention and treatment of cardiovascular diseases, such as atherosclerosis (23,24), postischaemic neovascularization, and heart failure (25).”
BackgroundWang, L., Zhang, C., Tian, L., Huang, J., Jia, L.-J., Tao, H., Yu, N.-W., & Li, B.-H. (2025) · Mammalian Genome · doi:10.1007/s00335-025-10124-0 · Cited by 1
ApoE-Knockout Mice: What are New Achievements of this Model of Atherosclerosis?
Lorkowska-Zawicka, B., & Jawień, J. (2021) · Acta Scientific Pharmaceutical Sciences · doi:10.31080/asps.2021.05.0737
Zhou, H., Cui, Z., Wang, H., Gao, T., Wang, L., Wu, J., Xiong, Z., Hao, J., & Zhao, M. (2022) · Research Square · doi:10.21203/rs.3.rs-1262603/v1 · Cited by 1
Deng, J. C., & Standiford, T. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102723-3.00053-6 · Cited by 1
Pulmonary Neutrophil Recruitment in Response to Inhaled LPS is Impaired in CD4 Deficient MicePreprint
Hamza, F. N., Alekhmimi, N., Matar, D. S. B., Barakzai, A., AlKattan, K. M., Heialy, S. A., & Kvietys, P. R. (2022) · Research Square · doi:10.21203/rs.3.rs-1796185/v1 · Cited by 1
Defective intestinal repair after short-term high fat diet due to loss of efferocytosisPreprint
Hill, A. A., Kim, M., Zegarra-Ruiz, D. F., Song, H. W., Renfroe, M. C., Major, A. M., Wu, W.-J. H., Norwood, K., & Diehl, G. E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/790220
“IL-10 both supports epithelial barrier repair 24,25 and increases macrophage efferocytosis capacity 26 .”
BackgroundMacrophage Surveillance and Immunity: Eating, Drinking, and Digesting
Ostrowski, P. P. (2020) · TSpace (University of Toronto)
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Thavarajah, R., & Ranganathan, K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.09.455749
Hypoxia shapes the immune landscape in lung injury promoting inflammation persistencePreprint
Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Lawson, H., Coelho, P., Murphy, F. A., Griffith, D. M., Zhang, A., Sánchez-García, M. A., Reyes, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.11.483935
Chamberland, M. M., Farrell, B. M., & Yeh, J. T. ‐. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.21.497076
“Although primary macrophages have been useful for efferocytosis studies [10-16], deriving primary macrophages can be”
BackgroundПетровна, Ч. С., Urazova, O. I., Shipulin, V. M., Анатольевна, Д. О., Кононова, Т. Е., Nevskaya, K. V., & Andreev, S. L. (2022) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2022-3-120-131
Role of sphingolipids in inflammatory carciongensis
El-Hindi, K. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.71949
Zhang, S., Zhao, X., Liu, L., Fang, J., Liu, W., & Zhang, H. (2023) · Research Square · doi:10.21203/rs.3.rs-2661427/v1
Maimaitiyimin, A., An, H., Chen, X., Li, X., Zhao, L., Bai, J., Luo, C., Zhuo, T., Huang, X., Maimaiti, A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3298232/v1
Additional file 8 of Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Zhao, H., Wu, L., Dai, J., Sun, K., Zi, Z., Guan, J., & Zhang, L. (2023) · Figshare · doi:10.6084/m9.figshare.24091591
Redfern, J. S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13947-5.00002-6
Akwaras, N., Adeniyi, O. S., Saalu, L. C., Ogli, S. A., Adugba, A. O., Onahinon, C., Eru, E. U., & Inyang, J. U. (2023) · International Journal of Innovative Science and Research Technology (IJISRT) · doi:10.38124/ijisrt/ijisrt24jun112
Inflammation Resolution Mediators: Future Prospects
Müller, R. L. J., Hoch, M., & Gupta, S. K. (2024) · Springer eBooks · doi:10.1007/978-981-97-0157-5_9
Santi, G. D., Pilati, C., Borgognone, A., & Tiberti, S. (2025) · Italian Journal of Wound Care · doi:10.4081/ijwc.2024.113
Deciphering immune cell heterogeneity in vascular diseases: Insights from single-cell sequencing
Zeng, W., Zhang, Y., Zhong, W., Chen, L., Gao, Y., Li, C., Zhao, Y., Shen, C., Zhao, R., Shi, B., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114719
Jin, J., Ma, L., Li, L., Zhou, X., Zhu, S., Shen, K., Xu, Q., Jiang, B., Gu, Y., Ding, Q., et al. (2025) · Respiratory Research · doi:10.1186/s12931-025-03241-6
“Furthermore, though instillation methods and co-culture methods were traditional approaches for studying efferocytosis [23, 41, 59, 60], using human neutrophils to assess effe-rocytosis of mouse macrophage has certain limitations.”
Pathogenetic factors of ischaemic cardiomyopathy: results of multivariate factor analysis
Петровна, Ч. С., Анатольевна, Д. О., Urazova, O. I., Shipulin, V. M., Andreev, S. L., Toporkova, A. K., & Litvinova, L. S. (2025) · Advanced targets in Biomedicine · doi:10.5922/atb-2025-1-1-6
Li, B., Zhang, M., Luo, Y., Li, D., Li, Q., Chen, L., Cai, L., Han, G., Yang, Z., & Kang, P. (2025) · Materials & Design · doi:10.1016/j.matdes.2025.115186
Broeckhoven, J. V., Erens, C., Sommer, D., Scheijen, E. E. M., Sanchez, S., Vidal, P. M., Dooley, D., Breedam, E. V., Quarta, A., Ponsaerts, P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19687237
Broeckhoven, J. V., Erens, C., Sommer, D., Scheijen, E. E. M., Sanchez, S., Vidal, P. M., Dooley, D., Breedam, E. V., Quarta, A., Ponsaerts, P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19687231
Zhang, H., Xia, N., Tang, T., 聂少芳, Zha, L., Zhang, M., Lv, B., Lu, Y., Jiao, J., Li, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578121
Broeckhoven, J. V., Erens, C., Sommer, D., Scheijen, E. E. M., Sanchez, S., Vidal, P. M., Dooley, D., Breedam, E. V., Quarta, A., Ponsaerts, P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19687240
Additional file 5 of Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Zhao, H., Wu, L., Dai, J., Sun, K., Zi, Z., Guan, J., & Zhang, L. (2023) · Figshare · doi:10.6084/m9.figshare.24091582
Additional file 7 of Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Zhao, H., Wu, L., Dai, J., Sun, K., Zi, Z., Guan, J., & Zhang, L. (2023) · Figshare · doi:10.6084/m9.figshare.24091588
Additional file 3 of Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Zhao, H., Wu, L., Dai, J., Sun, K., Zi, Z., Guan, J., & Zhang, L. (2023) · Figshare · doi:10.6084/m9.figshare.24091576
Additional file 1 of Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Zhao, H., Wu, L., Dai, J., Sun, K., Zi, Z., Guan, J., & Zhang, L. (2023) · Figshare · doi:10.6084/m9.figshare.24091570
Hu, M., Lin, Y., Men, X., Wang, S., Sun, X., Zhu, Q., Lu, D., Liu, S., Zhang, B., Cai, W., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14404328
Additional file 4 of Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Zhao, H., Wu, L., Dai, J., Sun, K., Zi, Z., Guan, J., & Zhang, L. (2023) · Figshare · doi:10.6084/m9.figshare.24091579
Additional file 2 of Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Zhao, H., Wu, L., Dai, J., Sun, K., Zi, Z., Guan, J., & Zhang, L. (2023) · Figshare · doi:10.6084/m9.figshare.24091573
Broeckhoven, J. V., Erens, C., Sommer, D., Scheijen, E. E. M., Sanchez, S., Vidal, P. M., Dooley, D., Breedam, E. V., Quarta, A., Ponsaerts, P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19687243
Additional file 6 of Ligand-based adoptive T cell targeting CA125 in ovarian cancer
Zhao, H., Wu, L., Dai, J., Sun, K., Zi, Z., Guan, J., & Zhang, L. (2023) · Figshare · doi:10.6084/m9.figshare.24091585
Broeckhoven, J. V., Erens, C., Sommer, D., Scheijen, E. E. M., Sanchez, S., Vidal, P. M., Dooley, D., Breedam, E. V., Quarta, A., Ponsaerts, P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19687228
Zhang, H., Xia, N., Tang, T., 聂少芳, Zha, L., Zhang, M., Lv, B., Lu, Y., Jiao, J., Li, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26578100
Broeckhoven, J. V., Erens, C., Sommer, D., Scheijen, E. E. M., Sanchez, S., Vidal, P. M., Dooley, D., Breedam, E. V., Quarta, A., Ponsaerts, P., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19687246
Metadata
- Authors
- Proto, J. D., Doran, A. C., Gusarova, G., Yurdagul, A., Sozen, E., Subramanian, M., Islam, M. N., Rymond, C. C., Du, J., Hook, J., Kuriakose, G., Bhattacharya, J., & Tabas, I.
- Affiliations
- Columbia University (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Tabas, Ira
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 49
- Issue
- 4
- Pages
- 666-677.e6
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC6192849
- OpenAlex
- W2894606588
- Cited by
- 441
- References
- 49
- Citations by year
- 2026: 49 · 2025: 68 · 2024: 68 · 2023: 73 · 2022: 72 · 2021: 47 · 2020: 33 · 2019: 29 · 2018: 2
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Dspace Repository (Marmara Üniversitesi) (submittedVersion, other-oa)
- Funders
- NIH (HL007343, HL122730, DoD-PR150672, HL132412, HL075662, HL127464, 5P30DK063608, P30CA013696)
- American Heart Association
- Scientific and Technological Research Council of Turkey
- BIDEB 2214/A Program
- Stony Wold-Herbert Fund Inc.
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- regulatory T cells, macrophage efferocytosis, efferocytosis, inflammation resolution, IL-13, IL-10, Vav1, Rac1, zymosan-induced peritonitis, lipopolysaccharide-induced lung injury, atherosclerosis, Treg depletion
- MeSH terms
- Animals, Cell Line, Cells, Cultured, Humans, Inflammation, Lipopolysaccharides, Lung Diseases, Macrophages, Mice, Inbred C57BL, Peritonitis, Phagocytosis, Zymosan, Interleukin-10, Apoptosis, Mice, Knockout, Interleukin-13, Jurkat Cells, T-Lymphocytes, Regulatory
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