A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

Price, April E.; Shamardani, Kiarash; Lugo, Kyler A.; Deguine, Jacques; Roberts, Allison W.; Lee, Bettina L.; Barton, Gregory M.

doi:10.1016/j.immuni.2018.07.016

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

SUMMARY Signaling by Toll‐like receptors (TLRs) on intestinal epithelial cells (IECs) is critical for intestinal homeostasis. To visualize epithelial expression of individual TLRs in vivo, we generated five strains of reporter mice. These mice revealed that TLR expression varied dramatically alon…