Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development
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Memory T-cells depend on mitochondrial and lipid metabolism for function and survival.
“Memory T-cells depend on mitochondrial and lipid metabolism for function and survival (11), and the bioactive sphingolipid ceramide was implicated in modulating mitochondrial metabolism and suppressing anti-tumor responses in aging T-cells (9).”
From Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity (2025) · cites this paper as [11]
Cited by
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Kassir, M. F., Lee, H. G., Oleinik, N. V., Wofford, W., Walton, C., Atilgan, F. C., Janneh, A. H., Chakraborty, P., Calisir, K., Percin, E., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-4740 · Cited by 10 · see citing works
- Authors
- O’Sullivan, D., van der Windt, G. J. W., Huang, S. C.-C., Curtis, J. D., Chang, C.-H., Buck, M. D., Qiu, J., Smith, A. M., Lam, W. Y., DiPlato, L. M., Hsu, F.-F., Birnbaum, M. J., Pearce, E. J., & Pearce, E. L.
- Corresponding author
- Pearce, Erika L.
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 49
- Issue
- 2
- Pages
- 375-376
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2907702333
- Cited by
- 58
- References
- 0
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 2 · 2014: 1
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Cancer Institute (R01CA181125)
- National Institute of Allergy and Infectious Diseases (R01AI091965)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- memory CD8+ T cells, fatty acid oxidation, T cell metabolism, glucose metabolism, fatty acid mobilization, T cell development, metabolic programming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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