Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

Miragaia, Ricardo J.; Gomes, Tomás; Chomka, Agnieszka; Jardine, Laura; Riedel, Angela; Hegazy, Ahmed N.; Whibley, Natasha; Tucci, Andrea; Chen, Xi; Lindeman, Ida; Emerton, Guy; Krausgruber, Thomas; Shields, Jacqueline; Haniffa, Muzlifah; Powrie, Fiona; Teichmann, Sarah A.

doi:10.1016/j.immuni.2019.01.001

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

&NA; Non‐lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single‐cell RNA‐seq to characterize 35,000 CD4+ regulatory (Treg) and memory (Tmem) T cells in mouse skin and colon, their respective draining lymph nodes (LNs) and s…