Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States

Wei, Spencer C.; Sharma, Roshan; Anang, Nana-Ama A.S.; Levine, Jacob H.; Zhao, Yang; Mancuso, James J.; Setty, Manu; Sharma, Padmanee; Wang, Jing; Pe’er, Dana; Allison, James P.

doi:10.1016/j.immuni.2019.03.004

Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States

&NA; Co‐stimulation regulates T cell activation, but it remains unclear whether co‐stimulatory pathways also control T cell differentiation. We used mass cytometry to profile T cells generated in the genetic absence of the negative co‐stimulatory molecules CTLA‐4 and PD‐1. Our data indicate that …