Gut Mycobiota in Immunity and Inflammatory Disease
Open accessAbstract
The mammalian intestine is colonized by a wealth of microorganisms-including bacteria, viruses, protozoa, and fungi-that are all integrated into a functional trans-kingdom community. Characterization of the composition of the fungal community-the mycobiota-has advanced further than the much-needed mechanistic studies. Recent findings have revealed roles for the gut mycobiota in the regulation of host immunity and in the development and progression of human diseases of inflammatory origin. We review these findings here while placing them in the context of the current understanding of the pathways and cellular networks that induce local and systemic immune responses to fungi in the gastrointestinal tract. We discuss gaps in knowledge and argue for the importance of considering bacteria-fungal interactions as we aim to define the roles of mycobiota in immune homeostasis and immune-associated pathologies.
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In multiple autoimmune disease mouse models, including EAE, autoimmune arthritis, and autoimmune renal disease, microbiota-specific induction of intestinal Th17 cells is associated with worsened autoimmune disease at extra-intestinal sites.
“Indeed, in multiple autoimmune disease mouse models, including EAE, autoimmune arthritis, and autoimmune renal disease, the microbiota-specific induction of intestinal Th17 cells was found to be associated with worsened autoimmune disease at extra-intestinal sites [50–52].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [51]
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References 160 · Cited by 246
Research works printed but not linked: 2
- Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, (2005). CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307, 254– 258. 15653504
- Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly YM, Glickman JN, and Garrett WS (2013). The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341, 569– 573. 23828891 PMC3807819
- Authors
- Li, X. V., Leonardi, I., & Iliev, I. D.
- Affiliations
- Cornell University (US)
- Corresponding author
- Iliev, Iliyan D.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 50
- Issue
- 6
- Pages
- 1365-1379
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC6585451
- OpenAlex
- W2952005092
- Cited by
- 246
- References
- 160
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 26 · 2023: 36 · 2022: 49 · 2021: 37 · 2020: 31 · 2019: 3
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Kenneth Rainin Foundation
- Irma T. Hirschl Trust
- Crohn's and Colitis Foundation
- Foundation for the National Institutes of Health
- National Institutes of Health (DK113136, AI146957, AI137157)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- gut mycobiome, fungal microbiota, host immunity, inflammatory diseases, immune homeostasis, gut microbiota, systemic immune response
- MeSH terms
- Gastrointestinal Microbiome, Animals, Disease Susceptibility, Gastroenteritis, Homeostasis, Humans, Immunity, Immunity, Innate, Host-Pathogen Interactions, Adaptive Immunity
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