The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
The cancer-immunity cycle: Indication, genotype, and immunotype
Open accessAbstract
The cancer-immunity cycle provides a framework to understand the series of events that generate anti-cancer immune responses. It emphasizes the iterative nature of the response where the killing of tumor cells by T cells initiates subsequent rounds of antigen presentation and T cell stimulation, maintaining active immunity and adapting it to tumor evolution. Any step of the cycle can become rate-limiting, rendering the immune system unable to control tumor growth. Here, we update the cancer-immunity cycle based on the remarkable progress of the past decade. Understanding the mechanism of checkpoint inhibition has evolved, as has our view of dendritic cells in sustaining anti-tumor immunity. We additionally account for the role of the tumor microenvironment in facilitating, not just suppressing, the anti-cancer response, and discuss the importance of considering a tumor's immunological phenotype, the "immunotype". While these new insights add some complexity to the cycle, they also provide new targets for research and therapeutic intervention.
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Citations
Cites
Oncology meets immunology: the cancer-immunity cycle.
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Self-citationPembrolizumab plus chemotherapy in metastatic non–small-cell lung cancer
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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
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Self-citationElements of cancer immunity and the cancer–immune set point
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Self-citationPredictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
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Self-citationMolecular and cellular insights into T cell exhaustion
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A framework for advancing our understanding of cancer-associated fibroblasts
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B cells and tertiary lymphoid structures promote immunotherapy response
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Cited by
Breast cancer: pathogenesis and treatments
Xiong, X., Zheng, L.-W., Ding, Y., Chen, Y.-F., Cai, Y.-W., Wang, L.-P., Huang, L., Liu, C.-C., Shao, Z.-M., & Yu, K.-D. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02108-4 · Cited by 958
Cancer immune evasion, immunoediting and intratumour heterogeneity
Roerden, M., & Spranger, S. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01111-8 · Cited by 265
Metabolic reprogramming in the tumor microenvironment of liver cancer
Lin, J., Rao, D., Zhang, M., & Gao, Q. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01527-8 · Cited by 251
“Metabolic derangements within the TME are increasingly recognized as one of the most important factors halting the CIC [94].”
BackgroundAdvances in molecular pathology and therapy of non-small cell lung cancer
Huang, Q., Li, Y., Huang, Y., Wu, J., Bao, W., Xue, C., Li, X., Dong, S., Dong, Z., & Hu, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02243-6 · Cited by 197
Wang, H., Arulraj, T., Ippolito, A., & Popel, A. S. (2024) · npj Digital Medicine · doi:10.1038/s41746-024-01188-4 · Cited by 122
Metadata
- Authors
- Mellman, I., Chen, D. S., Powles, T., & Turley, S. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2023-10
- Volume
- 56
- Issue
- 10
- Pages
- 2188-2205
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4387494986
- Cited by
- 953
- References
- 145
- FWCI
- 98.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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