Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis
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APOE aggregation in microglia initiates Aβ seeding in 5xFAD mice.
“recent evidence suggest that APOE aggregation in microglia initiates Aβ seeding in 5xFAD mice [18].”
From Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice (2026) · cites this paper as [18]
The title reproduced in the indexed copy states that APOE aggregation in microglia initiates β-amyloidosis by seeding it. However, the available main text is a correction notice (p. 263), not the study results, and it does not mention 5xFAD mice. That model-specific part of the claim is not supported by our copy. (LLM, conf=0.72)
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ApoE expression across the CNS: Who, What, Where, When, and How (much)?
Nolt, G. L., Lucido, C. C., Smith, L. M., & Johnson, L. A. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00028-x · Cited by 2 · see citing works
Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice
Raulin, A.-C., Alnobani, A., Rodriguez-Martinez, P., Lee, E., Linares, C., Yslas, A. R., Li, M., Ren, Y., Doss, S. V., Roy, B., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-04002-9
- Authors
- Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., Damkou, A., Hosang, L., Depp, C., Kamp, F., Scholz, P., Ewers, D., Giera, M., Ischebeck, T., Wurst, W., Wefers, B., Schifferer, M., Willem, M., Nave, K.-A., Haass, C., Arzberger, T., Jäkel, S., Wirths, O., Saher, G., & Simons, M.
- Corresponding author
- Berghoff, Stefan A.
- Simons, Mikael
- ORCID
- Kaji, Seiji
- Berghoff, Stefan A.
- Spieth, Lena
- Schlaphoff, Lennart
- Sasmita, Andrew O.
- Büschgens, Luca
- Kedia, Shreeya
- Zirngibl, Martin
- Damkou, Alkmini
- Depp, Constanze
- Kamp, Frits
- Scholz, Patricia
- Ewers, David
- Giera, Martin
- Ischebeck, Till
- Wurst, Wolfgang
- Wefers, Benedikt
- Schifferer, Martina
- Willem, Michael
- Nave, Klaus-Armin
- Haass, Christian
- Jäkel, Sarah
- Wirths, Oliver
- Saher, Gesine
- Simons, Mikael
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2025-01
- Volume
- 58
- Issue
- 1
- Pages
- 263
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4405012767
- Cited by
- 7
- References
- 0
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunity (publishedVersion, cc-by)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (PX458)
- Uehara Memorial Foundation (19\u2009K16915)
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Deutsche Forschungsgemeinschaft (EXC2145, 390857198, HA1737/16-1, TRR274-1)
- European Research Council
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- apolipoprotein E, protein aggregation, microglia, Alzheimer's disease, beta-amyloidosis, amyloid seeding, neuroinflammation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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