Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma
Abstract
Allergic inflammation of the airways has a critical role in asthma development. We investigated a suppressive effect of verproside (3,4-dihydroxy catalpol) isolated from the extract of Pseudolysimachion longifolium on asthmatic parameters--such as immunoglobulin E (IgE) level, cytokine release, eosinophilia, airway hyperresponsiveness and mucus hypersecretion--in an OVA-sensitized/challenged mouse model. Verproside significantly inhibited the increase of total IgE and the cytokines IL-4 and IL-13 in plasma and bronchoalveolar lavage fluid, and also effectively suppressed airway hyperresponsiveness, eosinophilia and mucus hypersecretion in OVA-induced asthmatic mice. The efficacy of verproside was comparable to montelukast, an anti-asthmatic drug that is currently available. These results suggest that verproside could be a major marker in herbal medicines that are used for asthma treatment, and could also act as a lead for anti-asthmatic drugs.
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Pseudolysimachion rotundum var. subintegrum has been used as an Asian traditional medicine for inflammatory diseases.
“Pseudolysimachion rotundum var. subintegrum (Plantaginaceae) has been used as an Asian traditional medicine for the treatment of inflammatory diseases [16].”
Verproside is a major biologically active compound of this plant, showing potent anti-inflammatory, antioxidant, and anti-asthmatic activities.
“Recently, we reported that verproside is a major biologically active compound of this plant, showing potent anti-inflammatory, antioxidant, and anti-asthmatic activities [33, 34].”
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New insights into the pathogenesis of asthma
Elias, J. A., Lee, C. G., Zheng, T., Ma, B., Homer, R. J., & Zhu, Z. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17748 · Cited by 407 · see citing works
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Choi, J., Choi, B. K., Kim, J. S., Lee, J.-W., Park, H. A., Ryu, H. W., Lee, S. U., Hwang, K. W., Yun, W.-K., Kim, H.-C., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0167098 · Cited by 30 · see citing works
Self-citationLee, K., Choi, J., Choi, B. K., Gu, Y.-M., Ryu, H. W., Oh, S.-R., & Lee, H.-J. (2019) · Molecules · doi:10.3390/molecules24102020 · Cited by 11 · see citing works
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- Authors
- Oh, S.-R., Young Lee, M., Ahn, K., Park, B.-Y., Kwon, O.-K., Joung, H., Lee, J., Kim, D.-Y., Lee, S., Kim, J. H., & Lee, H.-K.
- Affiliations
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Eulji University (KR)
- Corresponding author
- Lee, Hyeong-Kyu
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 6
- Issue
- 6
- Pages
- 978-986
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W2027206135
- Cited by
- 52
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 5 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 8 · 2014: 1 · 2013: 8 · 2012: 3
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- KRIBB Repository (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Keywords
- allergic asthma, airway inflammation, IgE, IL-4, IL-13, airway hyperresponsiveness, eosinophilia, mucus hypersecretion, herbal medicine, montelukast
- MeSH terms
- Acetates, Animals, Asthma, Bronchoalveolar Lavage Fluid, Cyclopropanes, Disease Models, Animal, Female, Glucosides, Immunoglobulin E, Lung, Mice, Inbred BALB C, Mucus, Ovalbumin, Plant Extracts, Pneumonia, Pulmonary Eosinophilia, Quinolines, Sulfides, Molecular Structure, Interleukin-4, Methacholine Chloride, Interleukin-13, Anti-Asthmatic Agents, Veronica, Iridoids, Mice, Iridoid Glucosides
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