Neutrophil cell surface receptors and their intracellular signal transduction pathways
Open accessAbstract
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue damage during autoimmune and inflammatory diseases. Neutrophils express a large number of cell surface receptors for the recognition of pathogen invasion and the inflammatory environment. Those include G-protein-coupled chemokine and chemoattractant receptors, Fc-receptors, adhesion receptors such as selectins/selectin ligands and integrins, various cytokine receptors, as well as innate immune receptors such as Toll-like receptors and C-type lectins. The various cell surface receptors trigger very diverse signal transduction pathways including activation of heterotrimeric and monomeric G-proteins, receptor-induced and store-operated Ca(2+) signals, protein and lipid kinases, adapter proteins and cytoskeletal rearrangement. Here we provide an overview of the receptors involved in neutrophil activation and the intracellular signal transduction processes they trigger. This knowledge is crucial for understanding how neutrophils participate in antimicrobial host defense and inflammatory tissue damage and may also point to possible future targets of the pharmacological therapy of neutrophil-mediated autoimmune or inflammatory diseases.
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Compared with those isolated on day 0, neutrophils isolated on day 14 may have contributed to neutrophil degranulation, antigen processing, and the presentation of endogenous peptide antigens and Toll-like receptor cascades, and the Toll-like receptor cascades contributed to the production of IL-1β.
“Compared with those isolated on day 0, neutrophils isolated on day 14 may have contributed to neutrophil degranulation, antigen processing, and the presentation of endogenous peptide antigens and Toll-like receptor cascades, and the Toll-like receptor cascades contributed to the production of IL-1 β (Figure 3E). 16”
From Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. (2020) · cites this paper as [16]
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Experimental — accuracy not yet measuredNeutrophil influx into a wound is mediated by chemical signals including IL-8/CXCL8.
“Their influx is mediated by a number of chemical signals, including IL-8, or CXCL8, as mentioned above, and neutrophils have over 30 different receptors that mitigate their migration and activation response [24].”
From Immunology of Wound Healing (2018) · cites this paper as [24]
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References 248 · Cited by 642
- Authors
- Futosi, K., Fodor, S., & Mócsai, A.
- Affiliations
- Semmelweis University (HU)
- Corvinus University of Budapest (HU)
- Corresponding author
- Mócsai, Attila
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 17
- Issue
- 3
- Pages
- 638-650
- ISSN
- 1567-5769 (ISSN-L)
- PMC
- PMC3827506
- OpenAlex
- W2137665452
- Cited by
- 642
- References
- 248
- Citations by year
- 2026: 32 · 2025: 54 · 2024: 72 · 2023: 56 · 2022: 58 · 2021: 61 · 2020: 48 · 2019: 51 · 2018: 45 · 2017: 56 · 2016: 46 · 2015: 36 · 2014: 24 · 2013: 3
- FWCI
- 20.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- International Immunopharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Semmelweis University Repository (Semmelweis University) (submittedVersion)
- Funders
- European Research Council (206283)
- Wellcome Trust (087782)
- European Union's Seventh Framework Program
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- neutrophils, cell surface receptors, signal transduction, G protein-coupled receptors, chemokine receptors, Fc receptors, selectins, integrins, Toll-like receptors, C-type lectin, store-operated calcium entry, heterotrimeric G proteins, cytoskeletal rearrangement, innate immunity, host defense against infection, autoimmune disease, therapeutic target
- MeSH terms
- Proto-Oncogene Mas, Animals, Humans, Neutrophils, Receptors, Cell Surface, Signal Transduction, Selectins
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