The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway
Abstract
Introduction The present study aimed to investigate whether miR-129-5p can regulate high-mobility group box protein 1 (HMGB1)-modulated TLRs/NF-kappaB inflammatory pathway that contributed to lipopolysaccharide (LPS)-induced podocyte apoptosis and acutekidneyinjury (AKI). Material and methods In vitro and in vivo models of sepsis were simulated using LPS-administrated podocytes and mice, respectively. The effects of LPS, mR-129-5p mimics and short hairpin RNA of HMGB1 (sh-HMGB1) on podocyte apoptosis were monitored using TUNEL staining. Protein expression was measured using western blotting. Survival outcomes were analyzed in septic mice with agomir-mR-129-5p administration. Results We observed that stimulation of podocytes with LPS significantly inhibits the expression of miR-129-5p, and overexpression of miR-129-5p protects against LPS-induced podocyte damage, over-activation of inflammatory response and apoptosis. In a mouse model, agomir-miR-129-5p administration significantly improves the survival outcomes in septic mice and LPS-induced AKI. Mechanically, LPS-induced the elevation of HMGB1, TLR2, TLR4 and nuclear NF-κB protein expression in vitro and in vivo are restrained by the overexpression of miR-129-5p. Conclusions Overexpression of miR-129-5p protects against LPS-induced podocyte apoptosis, inflammation and AKI in vivo and in vitro models of sepsis. The underlying molecular mechanism is mediated via attenuating HMGB1/TLRs/NF-κB signaling axis modulated inflammator…
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“In line with these observations, decreased levels of miR-129-5p have been associated with the induction of inflammatory processes in various other diseases such as kidney injury or rheumatoid arthritis [59, 84].”
From A role for astrocytic miR-129-5p in frontotemporal dementia (2025) · cites this paper as [59]
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2 retracted
Chen, Y., Jialing, Q., Chen, B., Lin, Y., Chen, Y., Xie, G., Qiu, J., Tong, H., & Jiang, D. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.023 · Cited by 137
Retracted(2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28409 · Cited by 40
RetractedHMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,385
Gao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124
Sepsis associated acute kidney injury
Poston, J. T., & Koyner, J. L. (2019) · BMJ · doi:10.1136/bmj.k4891 · Cited by 818
The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis
Deng, M., Tang, Y., Li, W., Wang, X., Zhang, R., Zhang, X., Zhao, X., Liu, J., Tang, C., Liu, Z., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.016 · Cited by 591
Yang, H., Antoine, D. J., Andersson, U., & Tracey, K. J. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.1212662 · Cited by 542
Autophagy in acute kidney injury
Kaushal, G. P., & Shah, S. V. (2016) · Kidney International · doi:10.1016/j.kint.2015.11.021 · Cited by 389
MD-2 is required for disulfide HMGB1–dependent TLR4 signaling
Yang, H., Wang, H., Ju, Z., Ragab, A. A., Lundbäck, P., Long, W., Valdes-Ferrer, S. I., He, M., Pribis, J. P., Li, J., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141318 · Cited by 375
High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
Yang, H., Wang, H., Chavan, S. S., & Andersson, U. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00087 · Cited by 357
Cited by
A role for astrocytic miR-129-5p in frontotemporal dementia
Kaurani, L., Pradhan, R., Schröder, S., Burkhardt, S., Schuetz, A.-L., Krüger, D. M., Pena, T., Heutink, P., Sananbenesi, F., & Fischer, A. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03338-y · Cited by 10
Metadata
- Authors
- Huang, X., Hou, X., Chuan, L., Wei, S., Wang, J., Yang, X., & Ru, J.
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 89
- Pages
- 107016
- ISSN
- 1567-5769
- Cited by
- 47
- References
- 46
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
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