Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity
Open accessAbstract
Per- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in environmental and biological samples and cause adverse health effects. Studies have predominately focused on long-chain PFAS, with far fewer addressing short-chain alternatives. This study leveraged embryonic zebrafish to investigate developmental toxicity of a short-chain series: perfluorobutane sulfonate (PFBS), perfluoropentanoic acid (PFPeA), perfluorobutane sulfonamide (FBSA), and 4:2 fluorotelomer sulfonic acid (4:2 FTS). Following static exposures at 8 h postfertilization (hpf) to each chemical (1-100 μM), morphological and behavioral endpoints were assessed at 24 and 120 hpf. Only FBSA induced abnormal morphology, while exposure to all chemicals caused aberrant larval behavior. RNA sequencing at 48 hpf following 47 μM exposures revealed only FBSA significantly disrupted normal gene expression. Measured tissue concentrations were FBSA > PFBS > 4:2 FTS > PFPeA. This study demonstrates functional head groups impact bioactivity and bioconcentration.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sulfonamido precursors elicit some of the same toxicological responses at lower doses than their terminal PFSA biotransformation products.
“Additionally, sulfonamido precursors elicit some of the same toxicological responses at lower doses than their terminal PFSA biotransformation products.54”
From Centurial Persistence of Forever Chemicals at Military Fire Training Sites (2023) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 54 · Cited by 64
Research works printed but not linked: 1
- Schwarzenbach R.P. Gschwend P.M. Imboden D.M. Environmental Organic Chemistry 2016 John Wiley & Sons
- Authors
- Rericha, Y., Cao, D., Truong, L., Simonich, M. T., Field, J. A., & Tanguay, R. L.
- Affiliations
- Oregon State University (US)
- Venue
- iScience
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 25
- Issue
- 2
- Pages
- 103789
- ISSN
- 2589-0042 (ISSN-L)
- PMC
- PMC8819378
- OpenAlex
- W4205619555
- Cited by
- 64
- References
- 54
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 17 · 2023: 9 · 2022: 9
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- iScience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIH
- US EPA
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
- Keywords
- per- and polyfluoroalkyl substances, short-chain PFAS, PFBS, PFPeA, developmental toxicity, zebrafish embryos, larval behavior, morphological abnormalities, gene expression, bioconcentration
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
