Src and Syk kinases: key regulators of phagocytic cell activation
Abstract
Src-family kinases and Syk tyrosine kinases have crucial roles in multiple leukocyte intracellular signaling pathways. In immunoreceptor-related pathways, these enzymes work together sequentially, with Src-family kinases phosphorylating specific protein substrates, which in turn recruit and activate Syk. Recent evidence indicates that several non-immunoreceptors also use Src-family kinases and Syk in this same fashion. In leukocyte integrin signaling, the interaction between the kinases is more complex, where they appear to act in a sequential manner but the mechanisms by which they are activated remain poorly defined. Elucidating the regulation of these tyrosine kinase-based signaling pathways in leukocytes remains an important goal in understanding how immune cells respond to the multitude of activating agents they encounter.
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In the context of microglia, the kinase responsible for phosphorylating the ITAM residues on DAP12 is likely to be Src or a Src-family kinase such as Lyn.
“In the context of microglia, the kinase responsible for phosphorylating the Immunoreceptor Tyrosine Activation Motif (ITAM) residues on DAP12 is likely to be Src [62] or a Src-family kinase such as Lyn [63, 64].”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [64]
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- Authors
- Berton, G., Mócsai, A., & Lowell, C. A.
- Affiliations
- University of Verona (IT)
- Semmelweis University (HU)
- University of California, San Francisco (US)
- Corresponding author
- Berton, Giorgio
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 26
- Issue
- 4
- Pages
- 208-214
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2032837321
- Cited by
- 214
- References
- 0
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 6 · 2023: 13 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 13 · 2013: 6 · 2012: 13
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fogarty International Center (TW006831, R03TW006831)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK58066, R01DK058066)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- Src family kinases, Syk, leukocyte signaling, immunoreceptor signaling, integrin signaling, kinase activation, leukocytes
- MeSH terms
- Syk Kinase, Animals, Enzyme Precursors, Inflammation, Phagocytes, Protein-Tyrosine Kinases, Receptors, Immunologic, Signal Transduction, Integrins, Mice, Knockout, Models, Immunological, src-Family Kinases, Intracellular Signaling Peptides and Proteins, Mice
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