Type I interferon response and innate immune sensing of cancer
Open accessAbstract
Unexpectedly, many cancers appear to induce a spontaneous adaptive T cell response. The presence of a T cell infiltrate has been linked to favorable clinical outcome in multiple cancer types. However, the innate immune pathways that bridge to an adaptive immune response under sterile conditions are poorly understood. Recent data have indicated that tumors can induce type I interferon (IFN) production by host antigen-presenting cells (APCs), which is required for a spontaneous T cell response in vivo. The innate immune sensing pathways that trigger type I IFN production are being elucidated. Host type I IFNs are also required for optimal therapeutic efficacy with radiation. This recently uncovered role for host type I IFNs for antitumor immunity has important fundamental and clinical implications.
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IFN-I is a versatile immune stimulator that could enhance the functions of DC, NK, and T cells.
“IFN-I is a versatile immune stimulator that could enhance the functions of DC, NK, and T cells [261].”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [261]
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References 57 · Cited by 375
- Authors
- Fuertes, M. B., Woo, S.-R., Burnett, B., Fu, Y.-X., & Gajewski, T. F.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Gajewski, Thomas F.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 34
- Issue
- 2
- Pages
- 67-73
- ISSN
- 1471-4906 (ISSN-L)
- PMC
- PMC3565059
- OpenAlex
- W1992088744
- Cited by
- 375
- References
- 57
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 27 · 2023: 46 · 2022: 57 · 2021: 38 · 2020: 25 · 2019: 28 · 2018: 19 · 2017: 29 · 2016: 22 · 2015: 18 · 2014: 13 · 2013: 15
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
- Funders
- National Cancer Institute (P01CA097296)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- type I interferon, innate immune recognition, tumor immunology, antigen-presenting cells, antitumor immunity, radiotherapy
- MeSH terms
- Animals, Humans, Immunity, Innate, Interferon Type I, Neoplasms, Signal Transduction, Mice
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