Lipid Droplets as Immune Modulators in Myeloid Cells
Abstract
Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are increasingly recognized as dynamic players in lipid metabolism, with important roles not only in diseases such as diabetes and cancer, but also in immune regulation. Alterations in immune cell function, such as myeloid cell activation, are connected to profound changes in LD numbers and LD protein composition. Thus, these organelles appear to be essential to metabolically support immune responses, and have a vital role in antigen crosspresentation, interferon (IFN) responses, production of inflammatory mediators, and pathogen clearance. Here, we review recent studies that report on the role of LDs in the modulation of immune cell function, primarily focusing on myeloid cells, such as macrophages and dendritic cells (DCs).
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Lipid-droplet rich foam cells in atherosclerosis show hallmarks of senescent cells and seem deleterious at all stages of disease.
“Importantly, lipid-droplet rich foam cells in atherosclerosis show hallmarks of senescent cells and they seem deleterious at all stages of disease10.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [10]
Lipid droplet containing immune cells in the periphery are detrimental, including foamy macrophages in atherosclerosis or lipid droplet-rich eosinophils in experimental models of allergy.
“This is in line with findings which have shown that lipid droplet containing immune cells in the periphery are detrimental, including foamy macrophages in atherosclerosis10 or lipid droplet-rich eosinophils in experimental models of allergy37.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [10]
Lipids within lipid droplets are often reutilized in the production of immune mediators.
“Lipids within LDs are often reutilized in the production of immune mediators [73].”
From Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation (2021) · cites this paper as [73]
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- Authors
- den Brok, M. H., Raaijmakers, T. K., Collado-Camps, E., & Adema, G. J.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Adema, Gosse J.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 39
- Issue
- 5
- Pages
- 380-392
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2793541083
- Cited by
- 203
- References
- 101
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 18 · 2023: 22 · 2022: 31 · 2021: 42 · 2020: 26 · 2019: 21 · 2018: 6
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- lipid droplets, myeloid cells, macrophages, dendritic cells, immune regulation, lipid metabolism, interferon response, inflammatory mediators, pathogen clearance, myeloid cell activation
- MeSH terms
- Animals, Humans, Immunologic Factors, Inflammation, Interferons, Antigen Presentation, Myeloid Cells, Lipid Droplets
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