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Cited by 221Wnt/β-catenin signaling in development and cancerCytokine Signaling Pathways and InteractionsImmune Response and Inflammation

Canonical and Non-Canonical Wnt Signaling in Immune Cells

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Chae, Wook-Jin, Bothwell, Alfred L.M.·2018·Trends in Immunology
DOI 10.1016/j.it.2018.08.006PMC PMC7367500
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Abstract

Cell differentiation, proliferation, and death are vital for immune homeostasis. Wnt signaling plays essential roles in processes across species. The roles of Wnt signaling proteins and Wnt ligands have been studied in the past, but the context-dependent mechanisms and functions of these pathways in immune responses remain unclear. Recent findings regarding the role of Wnt ligands and Wnt signaling in immune cells and their immunomodulatory mechanisms suggest that Wnt ligands and signaling are significant in regulating immune responses. We introduce recent key findings and future perspectives on Wnt ligands and their signaling pathways in immune cells as well as the immunological roles and functions of Wnt antagonists.

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  • Most studies investigating immune and blood cells have found canonical Wnt signalling to be integral, affecting haematopoietic stem cell self-renewal, B-cell development in the bone marrow, dendritic cell maturation, and T-cell activation and migration.

    “Most of the studies investigating immune and blood cells have found canonical Wnt signalling to be integral, since it has been shown to affect parts of haematopoietic stem cell self-renewal, B-cell development in the bone marrow, dendritic cell maturation and T-cell activation and migration [40,41].”

    From Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies (2020) · cites this paper as [41]

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Sorted by citations

Authors
Chae, W.-J., & Bothwell, A. L. M.
Affiliations
Yale University (US)
Corresponding author
  • Chae, Wook-Jin
  • Bothwell, Alfred L.M.
ORCID
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2018-10
Volume
39
Issue
10
Pages
830-847
ISSN
1471-4906 (ISSN-L)
DOI
10.1016/j.it.2018.08.006
PMC
PMC7367500
OpenAlex
W2891704573
Cited by
221
References
8
Citations by year
2026: 28 · 2025: 43 · 2024: 27 · 2023: 34 · 2022: 24 · 2021: 23 · 2020: 23 · 2019: 18
FWCI
1.59
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (R01CA168670, R21AI23858, R56AI27794, R21AI107957)
  • National Cancer Institute (P30CA016359)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
Wnt signaling, Wnt ligands, immune cells, immunomodulation, Wnt antagonists, immune homeostasis, cell differentiation, cell proliferation, cell death, Wnt/β-catenin signaling, non-canonical Wnt signaling
MeSH terms
Animals, Cell Differentiation, Homeostasis, Humans, Immune System, Immunity, Cellular, Wnt Proteins, Wnt Signaling Pathway

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