The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Emerging Activators and Regulators of Inflammasomes and Pyroptosis
Open accessAbstract
The inflammasome is a cytosolic immune signaling complex that induces inflammation and pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger or homeostasis-altering signals; they can play critical roles in the development of autoinflammatory conditions and cancer. Studies have now provided additional insights into the activation mechanisms and regulation of established inflammasome complexes, including NLRP1b, NLRP3, NOD-like receptor family apoptosis inhibitory protein (NAIP)-NLRC4, absent in melanoma (AIM)2, caspase-11, and pyrin. New activators and regulators of emerging NLRP6 and NLRP9b inflammasome complexes have also been described. We highlight the latest progress in our understanding of the molecular mechanisms governing inflammasome activation and pyroptosis, including the discovery of the pore-forming protein gasdermin D (GSDMD). We also discuss the importance of inflammasome activators and regulators in health and disease.
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Cites
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Swanson, K. V., Deng, M., & Ting, J. P.-Y. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0165-0 · Cited by 4,884
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Liu, X., Zhang, Z., Ruan, J., Pan, Y., Magupalli, V. G., Wu, H., & Lieberman, J. (2016) · Nature · doi:10.1038/nature18629 · Cited by 3,202
Pore-forming activity and structural autoinhibition of the gasdermin family
Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
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Non-canonical inflammasome activation targets caspase-11
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Inflammatory caspases are innate immune receptors for intracellular LPS
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
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Inflammasomes in health and disease
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Cited by
The Signaling Pathways Regulating NLRP3 Inflammasome Activation
Chen, M.-Y., Ye, X.-J., He, X.-H., & Ouyang, D.-Y. (2021) · Inflammation · doi:10.1007/s10753-021-01439-6 · Cited by 154
Kay, C., Wang, R., Kirkby, M., & Man, S. M. (2020) · Immunological Reviews · doi:10.1111/imr.12906 · Cited by 97
Self-citationFungal cell wall components modulate our immune system
Briard, B., Fontaine, T., Kanneganti, T.-D., Gow, N. A. R., & Papon, N. (2021) · The Cell Surface · doi:10.1016/j.tcsw.2021.100067 · Cited by 42
Metadata
- Authors
- Xue, Y., Enosi Tuipulotu, D., Tan, W. H., Kay, C., & Man, S. M.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 40
- Issue
- 11
- Pages
- 1035-1052
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2982045176
- Cited by
- 509
- References
- 28
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Xue, Y., Enosi Tuipulotu, D., Tan, W. H., Kay, C., & Man, S. M. (2019). Emerging Activators and Regulators of Inflammasomes and Pyroptosis. Trends in Immunology. https://doi.org/10.1016/j.it.2019.09.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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