Neuroimmune Connections in Aging and Neurodegenerative Diseases
Abstract
In recent years, the inter-relationship between the innate immune system and the central nervous system (CNS) has moved to the forefront of biomedical research, with the discovery that these two physiological systems modulate each other by a steady mutual interaction. During normal brain aging, but also under certain pathological conditions, this crosstalk can go beyond physiological control, resulting in an unresolved inflammatory response of the CNS-resident immune cells that might initiate and propagate the progression of severe tissue damage and neurodegeneration. In this review, we focus on the impact of CNS-resident cells of the innate immune system for the development of neurodegenerative diseases, review immune pathway genes that have been identified, and discuss the vicious cycle between inflammation and neurodegeneration.
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Over 70 loci are associated with conferring risk for late-onset Alzheimer's disease.
“In recent years, genome wide association studies (GWASs) and analyses of rare-coding variants have identified over 70 loci associated with conferring risk for late-onset AD (LOAD).”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [7]
Loci associated with Alzheimer's disease risk are enriched in genes expressed in microglia.
“Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated with AD risk are enriched in genes expressed in microglia.”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [7]
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- Authors
- Scheiblich, H., Trombly, M., Ramirez, A., & Heneka, M. T.
- Affiliations
- University of Bonn (DE)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Heneka, Michael T.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 41
- Issue
- 4
- Pages
- 300-312
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W3009304300
- Cited by
- 166
- References
- 102
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 22 · 2023: 39 · 2022: 32 · 2021: 28 · 2020: 14
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- Open Repository and Bibliography (University of Luxembourg) (submittedVersion)
- DZNE Pub (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- neuroinflammation, neurodegenerative diseases, brain aging, innate immune system, central nervous system, microglia, neuroimmune interactions
- MeSH terms
- Aging, Central Nervous System, Humans, Inflammation, Neurodegenerative Diseases
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