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Cited by 20Immune cells in cancerPhagocytosis and Immune RegulationBioinformatics and Genomic Networks

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Reframing macrophage diversity with network motifs

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Pizzurro, Gabriela A., Miller-Jensen, Kathryn·2023·Trends in Immunology
DOI 10.1016/j.it.2023.10.009PMC PMC11057955
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Abstract

A binary classification of macrophage activation as inflammatory or resolving does not capture the diversity of macrophage states observed in tissues. However, framing macrophage activation as a continuous spectrum of states overlooks the intracellular and extracellular networks that regulate and coordinate macrophage responses. Here, we suggest that the systems biology concept of network motifs, which incorporate rules of local molecular interactions, is useful for reframing macrophage activation. Because network motifs can be used to regulate distinct biological functions, they offer a simplified unit that can be compared across organismal, tissue, and disease contexts. Moreover, defining macrophage states as combinations of functional modules regulated by network motifs offers a framework to ultimately predict and target macrophage responses arising in complex environments.

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Metadata

Authors
Pizzurro, G. A., & Miller-Jensen, K.
Affiliations
Yale University (US)
ORCID
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2023-12
Volume
44
Issue
12
Pages
965-970
ISSN
1471-4906 (ISSN-L)
DOI
10.1016/j.it.2023.10.009
PMC
PMC11057955
OpenAlex
W4388537248
Cited by
20
References
1
Citations by year
2026: 8 · 2025: 5 · 2024: 7
FWCI
0.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Immunology (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation (MCB2231765)
  • National Institutes of Health (1U01CA238728, 2R01GM123011)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords
macrophage activation, network motifs, systems biology, macrophage polarization, intracellular signaling networks, functional modules
MeSH terms
Humans, Inflammation, Macrophage Activation, Macrophages, Phagocytosis, Systems Biology

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CoChat. (2026). Citation check: Reframing macrophage diversity with network motifs. https://app.cochat.ai/papers/10.1016/j.it.2023.10.009
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Pizzurro, G. A., & Miller-Jensen, K. (2023). Reframing macrophage diversity with network motifs. Trends in Immunology. https://doi.org/10.1016/j.it.2023.10.009