The impact of oral Polypodium leucotomos extract on ultraviolet B response: A human clinical study
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Background There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.Objective This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).Methods In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.Results Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.Limitations Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.Conclusion The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.
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Polypodium leucotomos extract (PLE), derived from a tropical fern in Central and South America, has antioxidative, chemoprotective, immunomodulatory, and anti-inflammatory effects.
“Polypodium leucotomos extract (PLE) is derived from a tropical fern found in Central and South America and has antioxidative, chemoprotective, immunomodulatory, and anti-inflammatory effects [84, 85].”
From Sunscreens and Photoaging: A Review of Current Literature (2021) · cites this paper as [84]
In 22 individuals irradiated with UVB, UVA, and VL, oral PLE suppressed UVB-induced erythema within 2 h of administration.
“In a recent study of 22 individuals irradiated with UVB, UVA, and VL, oral PLE demonstrated suppressive effects on UVB-induced erythema within 2 h of administration [84].”
From Sunscreens and Photoaging: A Review of Current Literature (2021) · cites this paper as [84]
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References 25 · Cited by 84
- Authors
- Kohli, I., Shafi, R., Isedeh, P., Griffith, J. L., Al-Jamal, M. S., Silpa-archa, N., Jackson, B., Athar, M., Kollias, N., Elmets, C. A., Lim, H. W., & Hamzavi, I. H.
- Affiliations
- Henry Ford Health (US)
- University of Alabama at Birmingham (US)
- Corresponding author
- Hamzavi, Iltefat H.
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 77
- Issue
- 1
- Pages
- 33-41.e1
- ISSN
- 0190-9622 (ISSN-L)
- PMC
- PMC5730054
- OpenAlex
- W2597910756
- Cited by
- 84
- References
- 25
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 9 · 2018: 10 · 2017: 2
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Academy of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01BX003395)
- National Cancer Institute (R01CA193885)
- National Institute of Environmental Health Sciences (R01ES026219)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- UV-B radiation, photoprotection, UVB-induced skin damage, Fitzpatrick skin type, histopathology, colorimetry, oral administration
- MeSH terms
- Administration, Oral, Female, Humans, Male, Plant Extracts, Skin, Ultraviolet Rays, Polypodium
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