Onychomycosis
Abstract
Onychomycosis is a fungal nail infection caused by dermatophytes, nondermatophytes, and yeast, and is the most common nail disorder seen in clinical practice. It is an important problem because it may cause local pain, paresthesias, difficulties performing activities of daily life, and impair social interactions. In this continuing medical education series we review the epidemiology, risk factors, and clinical presentation of onychomycosis and demonstrate current and emerging diagnostic strategies.
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The AI model for onychomycosis could offer a promising approach for preliminary screening, highlighting regions of interest on WSIs for further evaluation and confirmation by dermatopathologists.
“Furthermore, this AI model could offer a promising approach for the preliminary screening of onychomycosis, highlighting regions of interest on WSIs for further evaluation and confirmation by dermatopathologists [33,34].”
From Artificial Intelligence in the Histopathological Assessment of Non-Neoplastic Skin Disorders: A Narrative Review with Future Perspectives (2025) · cites this paper as [33]
Decroos et al.'s AI-based approach for detection of fungal hyphae in PAS-stained WSIs of nail clippings was non-inferior to four dermatopathologists with different levels of experience with regard to specificity and accuracy, but more uncertain in regard to sensitivity.
“The results showed that AI was non-inferior to four dermatopathologists (with different levels of experience) with regard to specificity and accuracy, but more uncertain in regard to sensitivity.”
From Artificial Intelligence in the Histopathological Assessment of Non-Neoplastic Skin Disorders: A Narrative Review with Future Perspectives (2025) · cites this paper as [33]
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References 123 · Cited by 345
- Authors
- Lipner, S. R., & Scher, R. K.
- Affiliations
- Weill Cornell Medicine (US)
- Corresponding author
- Lipner, Shari R.
- ORCID
- Lipner, Shari R.
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 80
- Issue
- 4
- Pages
- 835-851
- ISSN
- 0190-9622 (ISSN-L)
- OpenAlex
- W2811270246
- Cited by
- 345
- References
- 123
- Citations by year
- 2026: 36 · 2025: 39 · 2024: 49 · 2023: 58 · 2022: 56 · 2021: 43 · 2020: 43 · 2019: 20 · 2018: 1
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nail Diseases and Treatments
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Microbiology › Actinomycetales infections and treatment
- Keywords
- onychomycosis, dermatophytes, non-dermatophyte molds, yeast, risk factors, clinical features, diagnosis
- MeSH terms
- Diagnosis, Differential, Foot Dermatoses, Hand Dermatoses, Humans, Physical Examination, Risk Factors, Onychomycosis, Prevalence, Polymerase Chain Reaction, Mycological Typing Techniques, Biofilms, Microscopy, Confocal, Tomography, Optical Coherence, Dermoscopy
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