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Cited by 31Atrial Fibrillation Management and OutcomesAcute Ischemic Stroke ManagementCardiac Arrhythmias and Treatments

Prevalence, management, and comorbidities of adults with atrial fibrillation in the United States, 2019 to 2023

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Oltman, Connor G., Kim, Taehyung P., Lee, James W.Y., Lupu, John D., Zhu, Ruoqing, Moussa, Issam D.·2024·JACC: Advances
DOI 10.1016/j.jacadv.2024.101330PMC PMC11686049
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Abstract

Background: Due to evolving risk factor profiles and an aging population, atrial fibrillation poses a significant public health challenge in the United States. Therefore, a contemporary and nationally representative epidemiological study is necessary to reassess atrial fibrillation's impact on the health care system. Objectives: The purpose of the study was to provide the most current and detailed assessment of atrial fibrillation's prevalence and management in the United States. Methods: This retrospective cohort study was performed using data from Epic's Cosmos platform between January 1, 2019, and December 31, 2023. This is a multicenter, population-based study encompassing data from over 259 million patient records. The study cohort, 4,834,977 patients with atrial fibrillation, were identified from an initial cohort of 124,247,691 residents of the United States aged 18 years and older. Results: This study identified 4,834,977 patients with nontransient atrial fibrillation, with a mean age of 76 years; 55.43% of the patients were male, and 83.05% were non-Hispanic White. The overall prevalence of atrial fibrillation was 3.89%, where 0.26% of adults under 50 and 24.58% of those 90 and older had the condition. Geographically, rural areas reported a higher prevalence (5.29%) than urban areas (3.66%), with the Midwest, South, and Northeast experiencing higher rates compared to the Mountain and Pacific states. Roughly 30% of individuals with atrial fibrillation did not receive anticoagulant medication. Conclusions: The findings of this geographically diverse and nationally representative investigation align with recent prevalence studies, highlighting the increased burden of atrial fibrillation on the United States health care system.

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  • In Japan, where average omega-3 intake approximates 1000 mg/d, age-adjusted AF incidence is substantially lower than in the US.

    “In Japan, where average omega-3 intake approximates this level118, age-adjusted AF incidence is substantially lower than in the US119, 120.”

    From Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 35 Trials including 114 592 Individuals (2026) · cites this paper as [119]

    The Results (Prevalence of atrial fibrillation) and Discussion report AF prevalence in the United States, not age-adjusted AF incidence in Japan or a Japan–US comparison. Searches for Japan, age-adjusted incidence, and omega-3 intake found no passage addressing the attributed comparison. The omega-3 intake clause has a separate citation in the citing sentence. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Oltman, C. G., Kim, T. P., Lee, J. W. Y., Lupu, J. D., Zhu, R., & Moussa, I. D.
Affiliations
  • University of Illinois Urbana-Champaign (US)
  • Carle Foundation Hospital (US)
Corresponding author
Oltman, Connor G.
ORCID
Venue
JACC: Advances
Publisher
Elsevier BV
Published
2024-11
Volume
3
Issue
11
Pages
101330
ISSN
2772-963X (ISSN-L)
DOI
10.1016/j.jacadv.2024.101330
PMC
PMC11686049
OpenAlex
W4403299194
Cited by
31
References
7
Citations by year
2026: 20 · 2025: 11
FWCI
9.33
Type
journal article
Language
en
Open access
Licence
Locations
  • JACC Advances (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords
atrial fibrillation, prevalence, anticoagulation, comorbidities, urban-rural differences, regional variation, population aging, healthcare burden

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