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Cited by 8Cardiac Fibrosis and RemodelingViral Infections and Immunology ResearchTakotsubo Cardiomyopathy and Associated Phenomena

Recurrent Adrenergic Stress Provokes Persistent Myocarditis in PD-1–Deficient Mice

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Hayashi, Tomohiro, Lim, Kenji Rowel Q., Kovacs, Attila, Mann, Douglas L.·2023·JACC: Basic to Translational Science
DOI 10.1016/j.jacbts.2023.07.012PMC PMC10774592
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Abstract

It is unclear how the immune system initiates effective tissue repair responses without also simultaneously activating adaptive immune responses to self-antigens released by damaged or necrotic cells. We studied the role of repetitive adrenergic mediated stress on cardiac injury wild-type and programmed death-1–deficient (PD-1−/−) mice treated with 3 intraperitoneal low doses of isoprotenerol followed by an intraperitoneal injection of high-dose ISO 7 days later (ISOprimed/ISOinjury). Repetitive adrenergic stress in ISOprimed/ISOinjury PD-1−/− mice resulted in a persistent dysregulated myocardial inflammatory response characterized by the expansion of autoreactive effector CD8+ T cells, increased cardiac hypertrophy, mild left ventricular dysfunction, and increased lethality when compared with ISOprimed/ISOinjury wild-type mice.

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  • PD-1-/- mice develop autoimmune myocarditis with significant infiltration of CD8+ T cells following repeated in vivo administration of isoproterenol.

    “PD-1 -/-mice developed autoimmune myocarditis with significant infiltration of CD8 + T cells following repeated in vivo administration of isoproterenol.”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [185]

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Cited by

Sorted by citations

Authors
Hayashi, T., Lim, K. R. Q., Kovacs, A., & Mann, D. L.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Mann, Douglas L.
ORCID
Venue
JACC: Basic to Translational Science
Publisher
Elsevier BV
Published
2023-12
Volume
8
Issue
12
Pages
1503-1517
ISSN
2452-302X (ISSN-L)
DOI
10.1016/j.jacbts.2023.07.012
PMC
PMC10774592
OpenAlex
W4386885105
Cited by
8
References
3
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 2
FWCI
1.57
Type
journal article
Language
en
Open access
Licence
Locations
  • JACC Basic to Translational Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health
  • US Department of Veterans Affairs
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
Keywords
myocarditis, adrenergic stress, PD-1 deficiency, isoproterenol, cardiac injury, autoreactive CD8+ T cells, cardiac hypertrophy, left ventricular dysfunction, tissue repair, self-tolerance, adaptive immune response

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