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ACC/AHA/ASNC Guidelines for the Clinical Use of Cardiac Radionuclide Imaging—Executive Summary
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“The use of caffeine, a nonselective competitive A 2A receptor antagonist, has been contraindicated before vasodilator MPI (3) because it attenuates the coronary hyperemia caused by the nonselective adenosine receptor agonists adenosine and dipyridamole in a dose-dependent manner (4).”
From Interaction of Caffeine With Regadenoson-Induced Hyperemic Myocardial Blood Flow as Measured by Positron Emission Tomography (2008) · cites this paper as [3]
In the citing paper
“The interaction of caffeine with adenosine-induced, dipyridamoleinduced, and even exercise-induced MBF changes (4,6) may limit the correct detection of coronary artery disease and subsequently the proper management of the patient, leading to the general recommendation to withhold caffeine for 24 h before vasodilator stress testing (3).”
From Interaction of Caffeine With Regadenoson-Induced Hyperemic Myocardial Blood Flow as Measured by Positron Emission Tomography (2008) · cites this paper as [3]
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“Although echocardiography and gated blood pool studies are well-established methods in cardiology, gated myocardial perfusion single-photon emission computed tomography (SPECT) is also known to have high accuracy and precision for measurement of the principal cardiac functional parameters [1, 4, 5].”
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Comparison of high efficiency CZT SPECT MPI to coronary angiography
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“In this regard, rest yocardial perfusion imaging (MPI) using technetium adiopharmaceuticals has been shown to be a valuable echnique (4).”
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“Although visual interpretation is always the first step, nuclear cardiology trainees need to become competent in reading single-photon emission computed tomography (SPECT) images [1, 2].”
BackgroundCardiac autonomic imaging with SPECT tracers
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Coronary Artery Disease Progression Late After Successful Stent Implantation
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Self-citationThe role of PET quantification in cardiovascular imaging
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“PET myocardial perfusion is recommended for diagnosis or risk stratification of patients who have non-diagnostic other imaging tests (1).”
BackgroundSelf-citationCardiovascular Disease in Women
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Emerging molecular imaging targets and tools for myocardial fibrosis detection
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Self-citationNoninvasive Imaging of Cardiovascular Injury Related to the Treatment of Cancer
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“It is important to recognize that although ERNA is widely available for identifying LV dysfunction associated with chemotherapy-related cardiotoxicity (17,20,23,24), there are limitations to the procedure.”
BackgroundArnoldi, E., Lee, Y. S., Ruzsics, B., Weininger, M., Spears, J. R., Rowley, C. P., Chiaramida, S. A., Costello, P., Reiser, M. F., & Schoepf, U. J. (2011) · Journal of cardiovascular computed tomography · doi:10.1016/j.jcct.2011.10.007 · Cited by 64
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“The spline model of the LV shape defined a combined planar-conical sampling grid resulting in 648 myocardial tissue regions-of-interest (ROI), viewed as a 2D polar-map projection for convenient visualization.(24,25) A warped cylindrical blood ROI (8 mm diameter) was positioned automatically inside the LV cavity to max…”
MethodThe future of hybrid imaging—part 1: hybrid imaging technologies and SPECT/CT
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Self-citationSchuijf, J. D., Poldermans, D., Shaw, L. J., Jukema, J. W., Lamb, H. J., Roos, A., Wijns, W. C., van der Wall, E. E., & Bax, J. J. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1965-y · Cited by 63
“significant CAD (data based on references [14, 18]) 96”
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“Although a planar gated blood pool study had been a major diagnostic procedure for evaluating ventricular function in the field of nuclear medicine, recent guidelines for the clinical use of cardiac radionuclide imaging have accepted gated SPECT as one of the principal toolsfor evaluation of left ventricular function…”
MethodAppropriate Use Criteria for PET Myocardial Perfusion Imaging
Schindler, T. H., Bateman, T. M., Berman, D. S., Chareonthaitawee, P., Blanche, L. E. D., Dilsizian, V., Dorbala, S., Gropler, R. J., Shaw, L. J., Soman, P., et al. (2020) · Journal of Nuclear Medicine · doi:10.2967/jnumed.120.246280 · Cited by 63
“Critical determinants of outcome in patients with CAD can be determined by stress-related myocardial perfusion and function (26,27,29,30).”
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Semiconductor Detectors Allow Low-Dose–Low-Dose 1-Day SPECT Myocardial Perfusion Imaging
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“It is therefore conceivable that the radiation exposure experienced by patients undergoing any medical imaging procedure has recently gained growing attention and publicity (4–6), increasing the search for options to reduce radiation dose in SPECT MPI while maintaining diagnostic image quality.”
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“The selection criteria of subjects with low likelihood of cardiac disease are as follows: (1) Only patients with exercise stress were included; (2) Wall motion, determined by either echocardiography or gated SPECT, needed to be normal; (3) Patients who had normal coronary arteriography were included.”
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“For stress SPECT, pooled sensitivity is 87% with a specificity of 73% [ 12 ].”
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Guidelines for Clinical Use of Cardiac Nuclear Medicine (JCS 2010) : Digest Version
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“MPS procedures were standardized to protocols set forth by ACC/ AHA/American Society of Nuclear Cardiology.2 MPS protocols were predefined to be similar across each of the participating sites.”
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“MPI testing would be reasonable to guide the decision to perform invasive studies in patients with valvular heart disease without a chest pain syndrome.(3) Recommendation.”
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Diagnosing coronary artery disease with hybrid PET/CT: It takes two to tango
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“J Nucl Cardiol 1071-3581/$34.00 Copyright 2013 American Society of Nuclear Cardiology. doi:10.1007/s12350-013-9753-8 has been indisputably the most reliable and accurate technique for the noninvasive functional characterization of CAD.13 Particularly, cardiac positron emission tomography (PET) imaging has developed ra…”
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Self-citationOutcomes Research in Cardiovascular Imaging
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Myocardial arterial spin labeling
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New reconstruction algorithm allows shortened acquisition time for myocardial perfusion SPECT
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“Myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) is a wellestablished and widely accepted method for diagnostic and prognostic evaluation of patients with known or suspected coronary artery disease (CAD) [1].”
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“Because the hyperemic MBF response to regadenoson after caffeine administration lies well within the range of reported response to nonselective adenosine receptor agonists and bicycle stress (6), the present study suggests that regadenoson causes coronary hyperemia with and without prior caffeine ingestion in healthy…”
BackgroundInfluentialGender Differences in Ischemic Heart Disease
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“Vasodilator pharmacological stress perfusion imaging has been shown to be more accurate than exercise perfusion imaging in identification of CAD in both men and women with left bundle-branch block [ 43 ].”
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Screening Asymptomatic Diabetic Patients for Coronary Artery Disease
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ACCF/AHA Methodology for the Development of Quality Measures for Cardiovascular Technology
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“found, among patients after atrial switch operation, perfusion defects at rest in only 68 (26%) of the 264 studied segments. More important, only one of these defects was severe, only 20 (8%) were moderate and the vast majority, 47 defects (18%), were mild. Only very aggressive interpretation of SPECT results would re…”
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“The current guidelines of ACC/AHA/ASNC for the use of radionuclide imaging suggest the use of PET as an alternative to SPECT, without mentioning the role of quantitative PET [6].”
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“Specific testing modalities for certain cardiac diagnoses such as sarcoidosis, amyloidosis, and hypertrophic cardiomyopathy are included.(32) Although certain modalities are very specific for diagnoses such as sarcoidosis or amyloidosis,(34-37) cardiac MR was ranked Appropriate and of significant diagnostic utility ac…”
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“With SPECT a vast amount of data is available demonstrating its excellent diagnostic accuracy for detecting angiographically significant CAD with a sensitivity and specificity of 87–89 % and 73–75 %, respectively, depending on the choice of radionuclide and stress modality [34].”
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“For perfusion, the LV myocardium was divided into 17 segments, following the AHA/ACC/ASNC guidelines.(21) Total scores were calculated for both post-exercise and rest images using QPS software, yielding a summed stress score (SSS), a summed rest score (SRS), and a summed difference score (SDS).”
Method
Metadata
- Authors
- Klocke, F. J., Baird, M. G., Lorell, B. H., Bateman, T. M., Messer, J. V., Berman, D. S., O’Gara, P. T., Carabello, B. A., Russell, R. O., Cerqueira, M. D., St. John Sutton, M. G., DeMaria, A. N., Udelson, J. E., Kennedy, J. W., Verani, M. S., Williams, K. A., Antman, E. M., Smith, S. C., Alpert, J. S., Gregoratos, G., Anderson, J. L., Hiratzka, L. F., Faxon, D. P., Hunt, S. A., Fuster, V., Jacobs, A. K., Gibbons, R. J., & Russell, R. O.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 42
- Issue
- 7
- Pages
- 1318-1333
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2150815934
- Cited by
- 1,303
- References
- 64
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 12 · 2022: 14 · 2021: 30 · 2020: 22 · 2019: 21 · 2018: 23 · 2017: 38 · 2016: 33 · 2015: 59 · 2014: 75 · 2013: 87 · 2012: 101
- FWCI
- 53.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- myocardial perfusion imaging, myocardial scintigraphy
- MeSH terms
- Coronary Artery Disease, Emergency Treatment, Heart Diseases, Heart Failure, Humans, Myocardial Infarction, Radionuclide Imaging
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