The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Benefits of Cardiac Resynchronization Therapy for Heart Failure Patients With Narrow QRS Complexes and Coexisting Systolic Asynchrony by Echocardiography
Open accessAbstract
OBJECTIVES This study was designed to evaluate the role of cardiac resynchronization therapy (CRT) in heart failure (HF) patients with narrow QRS complexes (<120 ms) and echocardiographic evidence of mechanical asynchrony. BACKGROUND Cardiac resynchronization therapy is currently recommended to advanced HF patients with prolonged QRS duration. Echocardiographic assessment of systolic mechanical asynchrony has been proven useful to predict a favorable response after CRT. METHODS A total of 102 HF patients with New York Heart Association (NYHA) functional class III or IV were enrolled. Among them, 51 had wide QRS (>120 ms) and 51 had narrow QRS (<120 ms). Tissue Doppler imaging (TDI) was employed to select patients with systolic asynchrony (increased asynchrony index) in the narrow-QRS group. Clinical and echocardiographic assessments were performed at baseline and 3 months after CRT. RESULTS There was a significant reduction of left ventricular (LV) end-systolic volume in both narrow (122 +/- 42 cc vs. 103 +/- 47 cc, p < 0.001) and wide (148 +/- 74 cc vs. 112 +/- 64 cc, p < 0.001) QRS groups. Improvement of NYHA functional class (both p < 0.001), maximal exercise capacity (both p < 0.05), 6-min hall-walk distance (both p < 0.01), ejection fraction (both p < 0.001), and mitral regurgitation (both p < 0.005) was also observed. In both groups, the degree of baseline mechanical asynchrony determined LV reverse remodeling to a similar extent, as shown by the superimposed regression lines. Withholding CRT for 4 weeks resulted in loss of echocardiographic benefits. CONCLUSIONS Cardiac resynchronization therapy for HF patients with narrow QRS complexes and coexisting mechanical asynchrony by TDI results in LV reverse remodeling and improvement of clinical status. The amplitude of benefit is similar to the wide-QRS group provided that similar extent of systolic asynchrony is selected.
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Cites
The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure
Cleland, J. G. F., Daubert, J.-C., Erdmann, E., Freemantle, N., Gras, D., Kappenberger, L., & Tavazzi, L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050496 · Cited by 6,276
Cardiac Resynchronization in Chronic Heart Failure
Abraham, W. T., Fisher, W. G., Smith, A. L., Delurgio, D. B., Leon, A. R., Loh, E., Kocovic, D. Z., Packer, M., Clavell, A. L., Hayes, D. L., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013168 · Cited by 4,648
CARDIAC RESYNCHRONIZATION IN CHRONIC HEART FAILURE
Braham, W. I. T. A., Isher, W. E. G. F., Mith, L. S., Elurgio, D. A. B. D., Eon, A. N. R. L., Oh, E., Ocovic, D. U. Z. K., Acker, M. G., Lavell, L. C., Ayes, D. A. L. H., et al. (2002) · Cited by 3,808
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Yu, C.-M., Chau, E., Sanderson, J. E., Fan, K., Tang, M.-O., Fung, W.-H., Lin, H., Kong, S.-L., Lam, Y.-M., Hill, M. R. S., et al. (2002) · Circulation · doi:10.1161/hc0402.102623 · Cited by 1,110
Self-citationBaldasseroni, S., Opasich, C., Gorini, M., Lucci, D., Marchionni, N., Marini, M., Campana, C., Perini, G., Deorsola, A., Masotti, G., et al. (2002) · American Heart Journal · doi:10.1067/mhj.2002.121264 · Cited by 800
Yu, C.-M., Bleeker, G. B., Fung, J. W.-H., Schalij, M. J., Zhang, Q., van der Wall, E. E., Chan, Y.-S., Kong, S.-L., & Bax, J. J. (2005) · Circulation · doi:10.1161/circulationaha.105.538272 · Cited by 705
Self-citationYu, C.-M., Fung, W.-H., Lin, H., Zhang, Q., Sanderson, J. E., & Lau, C.-P. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03404-5 · Cited by 649
Self-citationYu, C.-M., Fung, J. W.-H., Zhang, Q., Chan, C.-K., Chan, Y.-S., Lin, H., Kum, L. C. C., Kong, S.-L., Zhang, Y., & Sanderson, J. E. (2004) · Circulation · doi:10.1161/01.cir.0000133276.45198.a5 · Cited by 624
Self-citationYu, C.-M., Lin, H., Zhang, Q., & Sanderson, J. E. (2003) · Heart · doi:10.1136/heart.89.1.54 · Cited by 618
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Cited by
Cardiac-Resynchronization Therapy in Heart Failure with a Narrow QRS Complex
Ruschitzka, F., Abraham, W. T., Singh, J. P., Bax, J. J., Borer, J. S., Brugada, J., Dickstein, K., Ford, I., Gorcsan, J., Gras, D., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1306687 · Cited by 825
Daubert, J.-C., Saxon, L., Adamson, P. B., Auricchio, A., Berger, R. D., Beshai, J. F., Breithard, O., Brignole, M., Cleland, J., DeLurgio, D. B., et al. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2012.07.025 · Cited by 467
Cardiac resynchronization therapy: state of the art 2013
Yu, C.-M., & Hayes, D. L. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs454 · Cited by 68
Self-citationIler, M. A., Hu, T., Ayyagari, S., Callahan, T. D., Civello, K. C., Thal, S. G., Wilkoff, B. L., & Chung, M. K. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.08.043 · Cited by 49
Metadata
- Authors
- Yu, C.-M., Chan, Y.-S., Zhang, Q., Yip, G. W. K., Chan, C.-K., Kum, L. C. C., Wu, L., Lee, A. P.-W., Lam, Y.-Y., & Fung, J. W.-H.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 48
- Issue
- 11
- Pages
- 2251-2257
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2016088603
- Cited by
- 273
- References
- 19
- FWCI
- 20.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yu, C.-M., Chan, Y.-S., Zhang, Q., Yip, G. W. K., Chan, C.-K., Kum, L. C. C., Wu, L., Lee, A. P.-W., Lam, Y.-Y., & Fung, J. W.-H. (2006). Benefits of Cardiac Resynchronization Therapy for Heart Failure Patients With Narrow QRS Complexes and Coexisting Systolic Asynchrony by Echocardiography. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2006.07.054
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