The changing face of heart transplantation
Open accessAbstract
It has been 40 years since the first human-to-human heart transplant performed in South Africa by Christiaan Barnard in December 1967. This achievement did not come as a surprise to the medical community but was the result of many years of early pioneering experimental work by Alexis Carrel, Frank Mann, Norman Shumway, and Richard Lower. Since then, refinement of donor and recipient selection methods, better donor heart management, and advances in immunosuppression have significantly improved survival. In this article, we hope to give a perspective on the changing face of heart transplantation. Topics that will be covered in this review include the changing patient population as well as recent advances in transplantation immunology, organ preservation, allograft vasculopathy, and immune tolerance.
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Administration of statins improves endothelial dysfunction, slows the development of cardiac allograft vasculopathy, and benefits survival.
“Administration of statins improves endothelial dysfunction, slows the development of cardiac allograft vasculopathy, and benefits survival.194”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [194]
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References 103 · Cited by 225
Research works printed but not linked: 3
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- Johnson MR, Aaronson KD, Canter CE, et al. Heart retransplanta- tion. Am J Transplant 2007;7:2075-81.
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- Authors
- Hunt, S. A., & Haddad, F.
- Affiliations
- Stanford University (US)
- Corresponding author
- Hunt, Sharon A.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 52
- Issue
- 8
- Pages
- 587-598
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2110621091
- Cited by
- 225
- References
- 103
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 9 · 2016: 15 · 2015: 11 · 2014: 13 · 2013: 20 · 2012: 33
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Keywords
- heart transplantation, history of heart transplantation, donor selection, recipient selection, immunosuppression, patient populations, transplantation immunology, organ preservation, allograft vasculopathy, immune tolerance
- MeSH terms
- Graft Rejection, Heart-Assist Devices, Humans, Immunosuppressive Agents, Lymphocyte Activation, Postoperative Complications, T-Lymphocytes, Signal Transduction, Heart Transplantation, Ultrasonography, Interventional, Patient Selection, Renal Insufficiency
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