The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Aortopathy Is Prevalent in Relatives of Bicuspid Aortic Valve Patients
Open accessAbstract
Objective We aimed to determine the prevalence of dilatation and abnormal elastic properties of aortic root in first degree relatives (FDRs) of bicuspid aortic valve patients. Background Evidence indicates that BAV is a genetic disorder. While FDRs of affected individuals have increased prevalence of BAV, their risk of aortic root abnormalities is unknown. Methods We studied dimensions as well as the elastic properties of the ascending aorta in 48 FDRs with morphologically normal, tricuspid aortic valves, 54 BAV patients, and 45 controls using two-dimensional echocardiography. Results The prevalence of aortic root dilatation was 32% in FDRs and 53% in BAV patients, whereas all controls demonstrated normal aortic dimensions (p<0.001). FDRs and BAVs had significantly lower aortic distensibility (1.7±1.4 and 1.4±2.0 vs. 2.5±1.6×10−3 mmHg, p<0.001) and greater aortic stiffness index (26.7±25.8 and 55.92±76.8 vs. 18.7±40.1, p=0.001) compared to controls. This difference remained significant in subjects without aortic root dilatation or hypertension (p=0.002 and p=0.004, respectively). Conclusions The aortic root is functionally abnormal and dilatation is common (32%) in first degree relatives of patients with BAV. Screening of FDRs by transthoracic 2-dimensional echocardiography should be considered for detection of aortic valve malformation and dilated ascending aorta.
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Roberts, W. C., & Ko, J. M. (2005) · Circulation · doi:10.1161/01.cir.0000155623.48408.c5 · Cited by 1,000
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Erbel (2014) · doi:10.1093/eurheartj/ehu281 · Cited by 4,451
Warnes, C. A., Williams, R. G., Bashore, T. M., Child, J. S., Connolly, H. M., Dearani, J. A., del Nido, P., Fasules, J. W., Graham, T. P., Hijazi, Z. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.190811 · Cited by 2,066
Stout, K. K., Daniels, C. J., Aboulhosn, J. A., Bozkurt, B., Broberg, C. S., Colman, J. M., Crumb, S. R., Dearani, J. A., Fuller, S., Gurvitz, M., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000603 · Cited by 1,602
2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease
Stout, K. K., Daniels, C. J., Aboulhosn, J. A., Bozkurt, B., Broberg, C. S., Colman, J. M., Crumb, S. R., Dearani, J. A., Fuller, S., Gurvitz, M., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.1029 · Cited by 1,080
Goldstein, S. A., Evangelista, A., Abbara, S., Arai, A., Asch, F. M., Badano, L. P., Bolen, M. A., Connolly, H. M., Cuéllar-Calàbria, H., Czerny, M., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.11.015 · Cited by 641
Metadata
- Authors
- Biner, S., Rafique, A. M., Ray, I., Cuk, O., Siegel, R. J., & Tolstrup, K.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 53
- Issue
- 24
- Pages
- 2288-2295
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2090312755
- Cited by
- 227
- References
- 2
- FWCI
- 17.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Biner, S., Rafique, A. M., Ray, I., Cuk, O., Siegel, R. J., & Tolstrup, K. (2009). Aortopathy Is Prevalent in Relatives of Bicuspid Aortic Valve Patients. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2009.03.027
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