CoChat
Sign Up
Cited by 436Obesity, Physical Activity, DietCardiovascular Health and Disease PreventionPhysical Activity and Health

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Physical Activity Reduces Systemic Blood Pressure and Improves Early Markers of Atherosclerosis in Pre-Pubertal Obese Children

Open access
Farpour-Lambert, Nathalie J., Aggoun, Yacine, Marchand, Laetitia M., Martin, Xavier E., Herrmann, François R., Beghetti, Maurice·2009·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2009.08.030
Open this paper in CoChat — free accountOpen PDF

Abstract

Objectives The aim of this study was to determine the effects of physical activity on systemic blood pressure (BP) and early markers of atherosclerosis in pre-pubertal obese children.Background Hypertension and endothelial dysfunction are premature complications of obesity.Methods We performed a 3-month randomized controlled trial with a modified crossover design: 44 pre-pubertal obese children (age 8.9 + or - 1.5 years) were randomly assigned (1:1) to an exercise (n = 22) or a control group (n = 22). We recruited 22 lean children (age 8.5 + or - 1.5 years) for baseline comparison. The exercise group trained 60 min 3 times/week during 3 months, whereas control subjects remained relatively inactive. Then, both groups trained twice/week during 3 months. We assessed changes at 3 and 6 months in office and 24-h BP, arterial intima-media thickness (IMT) and stiffness, endothelial function (flow-mediated dilation), body mass index (BMI), body fat, cardiorespiratory fitness (maximal oxygen consumption [VO(2)max]), physical activity, and biological markers.Results Obese children had higher BP, arterial stiffness, body weight, BMI, abdominal fat, insulin resistance indexes, and C-reactive protein levels, and lower flow-mediated dilation, VO(2)max, physical activity, and high-density lipoprotein cholesterol levels than lean subjects. At 3 months, we observed significant changes in 24-h systolic BP (exercise -6.9 + or - 13.5 mm Hg vs. control 3.8 + or - 7.9 mm Hg, -0.8 + or - 1.5 standard deviation score [SDS] vs. 0.4 + or - 0.8 SDS), diastolic BP (-0.5 + or - 1.0 SDS vs. 0 + or - 1.4 SDS), hypertension rate (-12% vs. -1%), office BP, BMI z-score, abdominal fat, and VO(2)max. At 6 months, change differences in arterial stiffness and IMT were significant.Conclusions A regular physical activity program reduces BP, arterial stiffness, and abdominal fat; increases cardiorespiratory fitness; and delays arterial wall remodeling in pre-pubertal obese children. (Effects of Aerobic Exercise Training on Arterial Function and Insulin Resistance Syndrome in Obese Children: A Randomized Controlled Trial; NCT00801645).

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2009.08.030

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 54 references

Research works printed but not linked: 1

  1. Watts, 2004, Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents, J Am Coll Cardiol, 43, 1823, 10.1016/j.jacc.2004.01.032 · DOI

Cited by

Sorted by citations

Items 301–400 of 436

Related

See all

Metadata

Authors
Farpour-Lambert, N. J., Aggoun, Y., Marchand, L. M., Martin, X. E., Herrmann, F. R., & Beghetti, M.
Affiliations
University of Geneva (CH)
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2009-12
Volume
54
Issue
25
Pages
2396-2406
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2009.08.030
OpenAlex
W2016296487
Cited by
436
References
54
Citations by year
2026: 7 · 2025: 18 · 2024: 23 · 2023: 21 · 2022: 28 · 2021: 31 · 2020: 31 · 2019: 31 · 2018: 27 · 2017: 31 · 2016: 23 · 2015: 36 · 2014: 22 · 2013: 32 · 2012: 35
FWCI
24.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • National Science Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (103853, 3200B0)
  • Hôpitaux Universitaires de Genève
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
physical activity, aerobic exercise training, childhood obesity, prepubertal children, blood pressure, hypertension, atherosclerosis, arterial stiffness, intima-media thickness, endothelial function, flow-mediated dilation, cardiorespiratory fitness, VO2max, abdominal fat, arterial remodeling, insulin resistance, C-reactive protein, hypertension prevention, obesity prevention, hypertension screening
MeSH terms
Body Height, Body Weight, Child, Endothelium, Vascular, Female, Humans, Hypertension, Insulin Resistance, Cholesterol, HDL, Male, Obesity, Oxygen Consumption, Physical Fitness, Puberty, Regional Blood Flow, Ultrasonography, Vasodilation, Biomarkers, Exercise, Body Mass Index, Exercise Tolerance, Carotid Artery, Common, Tunica Intima, Tunica Media, Cross-Over Studies, Atherosclerosis, Body Fat Distribution

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review