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Progression From Paroxysmal to Persistent Atrial Fibrillation

Open access
de Vos, Cees B., Pisters, Ron, Nieuwlaat, Robby, Prins, Martin H., Tieleman, Robert G., Coelen, Robert-Jan S., van den Heijkant, Antonius C., Allessie, Maurits A., Crijns, Harry J.G.M.·2010·Journal of the American College of Cardiology

Abstract

OBJECTIVES: We investigated clinical correlates of atrial fibrillation (AF) progression and evaluated the prognosis of patients demonstrating AF progression in a large population. BACKGROUND: Progression of paroxysmal AF to more sustained forms is frequently seen. However, not all patients will progress to persistent AF. METHODS: We included 1,219 patients with paroxysmal AF who participated in the Euro Heart Survey on AF and had a known rhythm status at follow-up. Patients who experienced AF progression after 1 year of follow-up were identified. RESULTS: Progression of AF occurred in 178 (15%) patients. Multivariate analysis showed that heart failure, age, previous transient ischemic attack or stroke, chronic obstructive pulmonary disease, and hypertension were the only independent predictors of AF progression. Using the regression coefficient as a benchmark, we calculated the HATCH score. Nearly 50% of the patients with a HATCH score >5 progressed to persistent AF compared with only 6% of the patients with a HATCH score of 0. During follow-up, patients with AF progression were more often admitted to the hospital and had more major adverse cardiovascular events. CONCLUSIONS: A substantial number of patients progress to sustained AF within 1 year. The clinical outcome of these patients regarding hospital admissions and major adverse cardiovascular events was worse compared with patients demonstrating no AF progression. Factors known to cause atrial structural remodeling (age and underlying heart disease) were independent predictors of AF progression. The HATCH score may help to identify patients who are likely to progress to sustained forms of AF in the near future.

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Metadata

Authors
de Vos, C. B., Pisters, R., Nieuwlaat, R., Prins, M. H., Tieleman, R. G., Coelen, R.-J. S., van den Heijkant, A. C., Allessie, M. A., & Crijns, H. J. G. M.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2010-02
Volume
55
Issue
8
Pages
725-731
ISSN
0735-1097 (ISSN-L)
OpenAlex
W1537095672
Cited by
720
References
1
FWCI
23.71
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Progression From Paroxysmal to Persistent Atrial Fibrillation. https://app.cochat.ai/papers/10.1016/j.jacc.2009.11.040
The paper
de Vos, C. B., Pisters, R., Nieuwlaat, R., Prins, M. H., Tieleman, R. G., Coelen, R.-J. S., van den Heijkant, A. C., Allessie, M. A., & Crijns, H. J. G. M. (2010). Progression From Paroxysmal to Persistent Atrial Fibrillation. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2009.11.040

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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