Imaging Atherosclerotic Plaque Inflammation by Fluorodeoxyglucose With Positron Emission Tomography
Open accessAbstract
Inflammation is a determinant of atherosclerotic plaque rupture, the event leading to most myocardial infarctions and strokes. Although conventional imaging techniques identify the site and severity of luminal stenosis, the inflammatory status of the plaque is not addressed. Positron emission tomography imaging of atherosclerosis using the metabolic marker fluorodeoxyglucose allows quantification of arterial inflammation across multiple vessels. This review sets out the background and current and potential future applications of this emerging biomarker of cardiovascular risk, along with its limitations.
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Applying 18F-FDG PET-CT in coronary arteries is challenging because 18F-FDG accumulates in metabolically active myocardium.
“Applying this technique in coronary arteries is challenging, as 18F-FDG accumulates in the metabolically active myocardium as well144.”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [144]
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References 100 · Cited by 236
Research works printed but not linked: 5
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- Authors
- Rudd, J. H. F., Narula, J., Strauss, H. W., Virmani, R., Machac, J., Klimas, M., Tahara, N., Fuster, V., Warburton, E. A., Fayad, Z. A., & Tawakol, A. A.
- Affiliations
- University of Cambridge (GB)
- University of California, Irvine (US)
- CVPath Institute (US)
- Kurume University (JP)
- Icahn School of Medicine at Mount Sinai (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Rudd, James H.F.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 55
- Issue
- 23
- Pages
- 2527-2535
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1574373575
- Cited by
- 236
- References
- 100
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 28 · 2015: 18 · 2014: 30 · 2013: 16 · 2012: 29
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIHR Cambridge Biomedical Center
- British Heart Foundation
- GlaxoSmithKline
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- atherosclerotic plaque inflammation, fluorodeoxyglucose, FDG-PET, positron emission tomography, plaque rupture, cardiovascular risk markers, myocardial infarction, stroke
- MeSH terms
- Animals, Arteries, Biopsy, Needle, Coronary Artery Disease, Disease Models, Animal, Female, Humans, Image Processing, Computer-Assisted, Immunohistochemistry, Inflammation, Male, Radiographic Image Enhancement, Sensitivity and Specificity, Severity of Illness Index, Cohort Studies, Fluorodeoxyglucose F18, Positron-Emission Tomography, Atherosclerosis
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