Simvastatin Effects on Skeletal Muscle
Larsen, Steen, Stride, Nis, Hey-Mogensen, Martin, Hansen, Christina N., Bang, Lia E., Bundgaard, Henning, Nielsen, Lars B., Helge, Jørn W. +1 more·2013·Journal of the American College of Cardiology
Cited by (165)
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- Validation of a pharmacological model for mitochondrial dysfunction in healthy subjects using simvastatin: A randomized placebo-controlled proof-of-pharmacology studyMarcus P.J. van Diemen, Cécile L. Berends, Naila Akram, Joep Wezel, Wouter M. Teeuwisse, Bert Mik, Hermien E. Kan, Andrew Webb, Jan‐Willem M. Beenakker, Geert Jan Groeneveld · 2017 · European Journal of Pharmacology
- Validation of a clinically-relevant rodent model of statin-associated muscle symptoms for use in pharmacological studiesJordon Candice Irwin, Andrew Stuart Fenning, K. Ryan, Rebecca Kate Vella · 2018 · Toxicology and Applied Pharmacology
- Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affectedLiselotte Bruun Christiansen, Tine Lovsø Dohlmann, Trine Pagh Ludvigsen, Ewa Parfieniuk, Michał Ciborowski, Łukasz Szczerbiński, Adam Jacek Kretowski, Claus Desler, Luca Tiano, Patrick Orlando et al. · 2021 · Scientific Reports
- Glucose homeostasis in statin users—The LIFESTAT studyThomas Hoffmann Morville, Tine Lovsø Dohlmann, Anja Birk Kuhlman, Tine Juul Monberg, Mimmi Torp, Bolette Hartmann, Jens Juul Holst, Steen Larsen, Jørn Wulff Helge, Flemming Dela · 2018 · Diabetes/Metabolism Research and Reviews
- Myopathy during treatment with the antianginal drug ranolazineCharles D. Kassardjian, Tian Xia, Georgirene D. Vladutiu, Lee-Jun C. Wong, Margherita Milone · 2014 · Journal of the Neurological Sciences
- Efficacy of fingolimod combined with alteplase in acute ischemic stroke and rehabilitation nursingLiantao Zhang, Zhang Jing, Lu Lingling, 华丽 · 2019 · Pakistan Journal of Pharmaceutical Sciences
- Effect of simvastatin on vascular tone in porcine coronary artery: Potential role of the mitochondriaHani Mhedi Almukhtar, M.J. Garle, Paul A. Smith, Richard E. Roberts · 2016 · Toxicology and Applied Pharmacology
- Alleviation of Simvastatin-Induced Myopathy in Rats by the Standardized Extract of Ginkgo Biloba (EGb761): Insights into the Mechanisms of ActionAmany Refaat Mahmoud, Esam Omar Kamel, Marwa A. Ahmed, Esraa A. Ahmed, Tarek Hamdy Abd‐Elhamid · 2019 · Cells Tissues Organs
- Do statins increase and Mediterranean diet decrease the risk of breast cancer?Michel de Lorgeril, Patricia Salen · 2014 · BMC Medicine
- Statin‐induced Myopathy and Ubiquinone Levels in Serum – Results from a Prospective, Observational StudyIlona Skilving, Jure Ačimovič, Anders Rane, Marie‐Louise Ovesjö, Linda Björkhem‐Bergman · 2015 · Basic & Clinical Pharmacology & Toxicology
- The effect of 8 weeks of physical training on muscle performance and maximal fat oxidation rates in patients treated with simvastatin and coenzyme Q10 supplementationAnja Birk Kuhlman, Lise Bluhme Mikkelsen, Signe Regnersgaard, Sophie Heinrichsen, Frederikke Hyldahl Nielsen, Jacob Frandsen, Patrick Orlando, Sonia Silvestri, Steen Larsen, Jørn Wulff Helge et al. · 2021 · The Journal of Physiology
- Effects of Statins on Fat Oxidation Improvements After Aerobic Exercise TrainingLaura Álvarez-Jiménez, Felix Morales‐Palomo, Alfonso Moreno‐Cabañas, JUAN FERNANDO ORTEGA, Ricardo Mora‐Rodríguez · 2022 · The Journal of Clinical Endocrinology & Metabolism
- Synergistic effect of atorvastatin and cyanidin-3-glucoside against angiotensin II-mediated vascular smooth muscle cell proliferation and migration through MAPK and PI3K/Akt pathwaysRungusa Pantan, Jiraporn Tocharus, Manussabhorn Phatsara, Apichart Suksamrarn, Chainarong Tocharus · 2016 · Archives of Pharmacal Research
- Effects of Benzo(e)pyrene on reactive oxygen/nitrogen species and inflammatory cytokines induction in human RPE cells and attenuation by mitochondrial-involved mechanismM. Cristina Kenney, MFernanda Estrago-Franco, Mohamed Tarek Moustafa, Mohammad Riazi-Esfahani, A. U. Sapkal, Rhina Piche-Lopez, A. Jayaprakash Patil, Ashish Sharma, Payam Falatoonzadeh, Marilyn Chwa et al. · 2016 · Journal of Ophthalmic and Vision Research
- Effects of prior treatment with simvastatin on skeletal muscle structure and mitochondrial enzyme activities during early phases of sepsis.Elif Özkök, Hatice Yorulmaz, Gulten Ates, Piraye Serdaroglu-Oflazer, Ayşe Tamer · 2014 · Europe PMC (PubMed Central)
- Evaluation of Coenzyme Q10 Redox Status as a Biomarker of Oxidative StressOlga A. Goroshko, Людмила Михайловна Красных, Vladimir G. Kukes, Vladlena I. Zozina · 2019 · The Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products Regulatory Research and Medicine Evaluation
- Evidence for metabolic aberrations in asymptomatic persons with type 2 diabetes after initiation of simvastatin therapyManish Suneja, Daniel K. Fox, Brian D. Fink, Judy A. Herlein, Christopher M. Adams, William I. Sivitz · 2015 · Translational research
- Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle ExpressionMiljenko Valentin Panajatovic, François Singh, Stephan Krähenbühl, Jamal Bouitbir · 2020 · Biomedicines
- Elucidating the effect of drug-induced mitochondrial dysfunction on insulin signaling and glucose handling in skeletal muscle cell line (C2C12) in vitroAuxiliare Kuretu, Mmamosheledi E. Mothibe, Phikelelani Siphosethu Ngubane, Ntethelelo Hopewell Sibiya · 2024 · PLoS ONE
- Exercise Training Protects against Atorvastatin-Induced Skeletal Muscle Dysfunction and Mitochondrial Dysfunction in the Skeletal Muscle of RatsDae Yun Seo, Jun‐Won Heo, Mi‐Hyun No, Su-Zi Yoo, Jeong Rim Ko, Dong‐Ho Park, Ju‐Hee Kang, Chang‐Ju Kim, Su‐Jeen Jung, Jin Han et al. · 2020 · Journal of Clinical Medicine
- First reported case of rhabdomyolysis associated with concomitant use of cyclosporin, diltiazem, and simvastatinChristopher Thiam Seong Lim, Kar Wah Fuah · 2020 · Indian Journal of Nephrology
- Short-term cessation of statin therapy does not alter aerobic exercise performance in physically active middle-aged adultsKevin David Ballard, Sara M. Mazur, Beth A. Taylor, Paul D. Thompson · 2015 · The Physician and Sportsmedicine
- Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysisKovacic, Svenja, Habicht, Sandra D., Eckert, Gunter Peter · 2025 · Journal of Nutritional Science
- Effects of simvastatin associated with exercise on the mechanical resistance of muscle and bone in ratsJéssica Suzuki Yamanaka, Kaique Eduardo Carvalho Ribeiro, Gabriela Rezende Yanagihara, Antônio Carlos Shimano, Álvaro César de Oliveira Penoni · 2018 · Revista Brasileira de Ortopedia (English Edition)
- Nanomolar Cadmium Disrupts Neurotransmitter Release Timing via a ROS-dependent Mechanism at the Mouse Neuromuscular Junction: Modulation by Nanomolar Zn2+Arthur N. Khaziev, Andrei N. Tsentsevitsky, Eva A Kapliukhina, Alexey M. Petrov · 2026 · Neurochemical Research
- Differential effects of OATP2B1 on statin accumulation and toxicity in a beta cell modelJihoon Kwon, Michelle S. Kim, Christina Blagojevic, Jaymie Mailloux, Samantha J. Medwid, Rommel G. Tirona, Rennian Wang, Ute I. Schwarz · 2023 · Toxicology Mechanisms and Methods
- Two Cases of Levetiracetam-Induced Rhabdomyolysis With Low Levetiracetam Blood ConcentrationsKentaro Kodama, Toru Imai, Tsukasa Kuwana, Susumu Ootsuka, Kosaku Kinoshita · 2025 · Cureus
- Fluvastatin Reduces Glucose Tolerance in Healthy Young Individuals Independently of Cold Induced BAT ActivityMartina Felder, Claudia Irene Maushart, Gani Gashi, Jaël Rut Senn, Anton S. Becker, Julian Müller, Miroslav Baláž, Christian Wolfrum, Irene Andrea Burger, Matthias Johannes Betz · 2021 · Frontiers in Endocrinology
- Drug-Induced MyopathiesKewal K. Jain · 2021 · Springer eBooks
- Statins are Contraindicant to Diabetics - Urgent ProposalHarumi Okuyama, Tomohito Hamazaki, Yoichi Ogushi, Rokuro Hama, Hajime Uchino, Hiroyuki A. Watanabe, Michio Hashimoto · 2013 · Journal of Lipid Nutrition
- The Role of the Mitochondria in SAMSNeeltje A. E. Allard, Silvie Timmers · 2020 · Contemporary cardiology
- PENGARUH MADU TRIGONA TERHADAP STRESS OKSIDATIF PADA TIKUS PUTIH (Rattus norvegicus) YANG DIINDUKSI STATIN UNTUK MENCEGAH MIOTOKSISITASMirnawati Salampe, Peter Kabo, Yulia Yusrini Djabir · 2018 · Majalah Farmasi dan Farmakologi
- Drugs that Affect Lipid MetabolismWakana Ohashi, Yuichi Hattori · 2014 · Side effects of drugs annual
- Statins and Muscle DamageMatthew J. Sorrentino · 2018 · Elsevier eBooks
- The Way to Determine Coenzyme QPlácido Navas · 2013 · Journal of the American College of Cardiology
- Mechanisms and Predisposing Conditions for Statin‐Induced New‐Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic EffectsAli Nosrati Andevari, Mohsen Koolivand · 2026 · Endocrinology Diabetes & Metabolism
- ESTUDO CASO CONTROLE DE ALTERAÇÕES DE CREATINOFOSFOQUINASE EM USUÁRIOS DE UM LABORATÓRIO DO INTERIOR DO RIO GRANDE DO SULDanielly Joani Bullé, Renan Vitalis, Luiza Paza, Rafaela da Silva, Clairton Edinei dos Santos, Jane Dagmar Pollo Renner · 2015 · Cinergis
- ECMO (Extracorporeal Membrane Oxygenation) in rhabdomyolysis due to statin use use (case presentation)Mine Altınkaya Çavuş, Şerife Gökbulut Bektaş, Dilek Kazancı, Sema Turan · 2019 · Journal of Cardio-Vascular-Thoracic Anaesthesia and Intensive Care Society
- Association of statins with peak oxygen consumption in 4,941 adults: A cross-sectional studyCaio Eduardo Novaes, Eduardo Rondon, Caio Fernando Ribeiro Rizzo, Matheus Oscar de Oliveira, Francis Ribeiro de Souza, Maria Janieire de Nazaré Nunes Alves, Carlos Eduardo Negrão, Marcelo Rodrigues dos Santos · 2024 · IJC Heart & Vasculature
- Simvastatin Effects on Skeletal MuscleWeeranun Dechyapirom Bode, Ross J. Simpson · 2013 · Journal of the American College of Cardiology
- Efeitos do treinamento físico combinado periodizado e estatina em pessoas vivendo com HIV com dislipidemia: ensaio clínico randomizado, duplo-cego e placebo-controladoHugo Ribeiro Zanetti · 2018
- Dietary/Environmental Factors and Breast CancerMichel de Lorgeril, Patricia Salen · 2015 · Springer eBooks
- Regulation of legumain in human cellsRobert L. Smith · 2014 · NORA - Norwegian Open Research Archives
- Statin-induced MyopathyAnthony J. Dalby · 2017 · SA Heart
- ReplySteen Larsen, CHRISTINA NEIGAARD HANSEN, Jørn Wulff Helge, Flemming Dela · 2013 · Journal of the American College of Cardiology
- 6. Benefits of high cholesterol levels for all-cause mortality: biochemical basesHarumi Okuyama · 2015 · Wageningen Academic Publishers eBooks
- Drugs that affect lipid metabolismWakana Ohashi, Yuichi Hattori · 2014 · Side effects of drugs annual
- PGC-1β prevents statin-associated myotoxicity in oxidative skeletal muscleFrançois Singh, Joffrey Zoll, Urs Duthaler, Anne‐Laure Charles, Gilles LAVERNY, Daniel METZGER, Bernard Gény, Stephan Krähenbühl, Jamal Bouitbir · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Manifestations of Drug Toxicity on Mitochondria in the Nervous SystemJochen H.M. Prehn, Irene Llorente‐Folch · 2018 · Wiley eBooks
- Skeletal Muscle Mitochondrial ToxicityEric K. Herbert, S Herbert, Karl E. Herbert · 2018 · Wiley eBooks
- The Role of Muscle Protein and Energy Metabolism in Statin-Associated Muscle SymptomsPaul Leonard Greenhaff, Joanne E. Mallinson, Flemming Dela · 2020 · Contemporary cardiology
- Statins and physical activity in humanAnna Gawędzka, Malgorzata Elzbieta Knapik-Czajka, Jagoda Drąg · 2018 · Farmacja Polska
- Efeitos da sinvastatina associada ao exercício físico na resistência mecânica de músculos e ossos de ratosJéssica Suzuki Yamanaka, Kaique Eduardo Carvalho Ribeiro, Gabriela Rezende Yanagihara, Antônio Carlos Shimano, Álvaro César de Oliveira Penoni · 2017 · Revista Brasileira de Ortopedia
- ReplySteen Larsen, Nis Ottesen Stride, Martin Hey‐Mogensen, CHRISTINA NEIGAARD HANSEN, Lia Evi Bang, Henning Bundgaard, Lars Bøgeskov Nielsen, Jørn Wulff Helge, Flemming Dela · 2013 · Journal of the American College of Cardiology
- Faculty Opinions recommendation of Sources of Inter-individual Variability in the Therapeutic Response of Blood Glucose Control to Exercise in Type 2 Diabetes: Going Beyond Exercise Dose.Brendan Egan · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Nutracéuticos (monacolina K, berberina y coenzima Q10) en pacientes con hipercolesterolemia moderada y un riesgo cardiovascular bajo-moderado. Potenciales beneficios de los tratamientos combinadosFrancisco José Fernández‐Fernández, Raquel Sardina Ferreiro, E. Ameneiros-Lago · 2022 · Medicina de Familia SEMERGEN
- Do Statins Blunt the Beneficial Effect of Aerobic Exercise on Metabolic Flexibility?Tim Hollstein, Paolo Piaggi · 2023 · The Journal of Clinical Endocrinology & Metabolism
- Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose TissueIda Bager Christensen, Ida Blom, Tine Lovsø Dohlmann, Fabian Finger, Jørn Wulff Helge, Zachary Gerhart‐Hines, Flemming Dela, Steen Larsen · 2023 · The Journal of Clinical Endocrinology & Metabolism
- “Medicina mitocondrial” y diabetes mellitus: aspectos importantesJuan Santiago Serna–Trejos, Miren San Martin Murillo, Luis Miguel Ramírez-Burbano, Laura Carolina Neira–Ruiz · 2023 · Metro Ciencia
- Musculoskeletal systemMarion Joseph Fedoruk · 2023 · Elsevier eBooks
- Modeling of postprandial glycemic response by consecutive reaction kinetics model for precise glycemic controlCheng Li · 2023 · International Journal of Diabetes in Developing Countries
- Statins and the Risk, Mechanism and Research Progress of New Onset Diabetes Mellitus慧 王 · 2023 · Advances in Clinical Medicine
- Can exercise potentiate the effects of habitual medicines to lower blood pressure, blood lipids, and blood glucose?Ricardo Mora‐Rodríguez, Felix Morales‐Palomo, Laura Álvarez-Jiménez, Diego Mora‐Gonzalez, Alfonso Moreno‐Cabañas · 2025 · Exercise Sport and Movement
- Skeletal muscle toxicity and statins : role of mitochondrial adaptationsFrançois Singh · 2016 · theses.fr (ABES)
- Skeletal muscle oxidative capacity and tissue composition in heart failure with preserved ejection fractionMiles F. Bartlett, Jimin Ren, Satyam Sarma, James P. MacNamara, Tiffany L. Brazile, Denis J. Wakeham, Christopher M. Hearon, Kevin C. Lutz, Paul J. Fadel, Mark J. Haykowsky et al. · 2026 · Journal of Applied Physiology