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Effect of Endurance Exercise Training on Endothelial Function and Arterial Stiffness in Older Patients With Heart Failure and Preserved Ejection Fraction
Open accessAbstract
Objectives The study sought to evaluate the effects of endurance exercise training (ET) on endothelial-dependent flow-mediated arterial dilation (FMD) and carotid artery stiffness, and their potential contributions to the training-related increase in peak exercise oxygen consumption (Vo2) in older patients with heart failure with preserved ejection fraction (HFPEF).Background Elderly HFPEF patients have severely reduced peak Vo2, which improves with ET, however, the mechanisms of this improvement are unclear. FMD and arterial distensibility are critical components of the exercise response and are reduced with aging. However, it is unknown whether these improve with ET in elderly HFPEF or contribute to the training-related improvement in peak Vo2.Methods A total of 63 HFPEF patients (age 70 ± 7 years) were randomized to 16 weeks of ET (walking, arm and leg ergometry, n = 32) or attention control (CT) (n = 31). Peak Vo2, brachial artery FMD in response to cuff ischemia, carotid artery distensibility by high-resolution ultrasound, left ventricular function, and quality of life were measured at baseline and follow-up.Results ET increased peak Vo2 (ET: 15.8 ± 3.3 ml/kg/min vs. CT: 13.8 ± 3.1 ml/kg/min, p = 0.0001) and quality of life. However, brachial artery FMD (ET: 3.8 ± 3.0% vs. CT: 4.3 ± 3.5%, p = 0.88), and carotid arterial distensibility (ET: 0.97 ± 0.56 vs. CT: 1.07 ± 0.34 × 10(-3) mm·mm Hg(-2); p = 0.65) were unchanged. Resting left ventricular systolic and diastolic function were unchanged by ET.Conclusions In elderly HFPEF patients, 16 weeks of ET improved peak Vo2 without altering endothelial function or arterial stiffness. This suggests that other mechanisms, such as enhanced skeletal muscle perfusion and/or oxygen utilization, may be responsible for the ET-mediated increase in peak Vo2 in older HFPEF patients. (Prospective Aerobic Reconditioning Intervention Study [PARIS]; NCT01113840).
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“In older patients with HF with preserved ejection fraction, the increased peak V˙o2 after moderate-intensity continuous endurance exercise training was secondary to peripheral adaptations that resulted in increased peak exercise AV˙o2 difference without a change in cardiovascular function (ie, no change in peak exercise cardiac output, central artery stiffness, or peripheral arterial endothelial”
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“Several studies reported that (modest) weight loss caused by lifestyle interventions in obesity-related HFpEF patients improved exercise capacity but had no effect on cardiac structure or function.”
From The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF (2023) · cites this paper as [56]
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Citations
Cites
(1992) · PubMed · Cited by 33,716
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D. S., Charbonneau, F., Creager, M. A., Deanfield, J. E., Drexler, H., Gerhard‐Herman, M. D., Herrington, D. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,606
Self-citationTrends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction
Owan, T., Hodge, D. O., Herges, R. M., Jacobsen, S. J., Roger, V. L., & Redfield, M. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052256 · Cited by 4,209
Anderson, E. N. (1977) · eScholarship (California Digital Library) · Cited by 2,567
Rich, M. W., Beckham, V., Wittenberg, C., Leven, C. L., Freedland, K. E., & Carney, R. M. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511023331806 · Cited by 2,327
The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure.
Guyatt, G. H., Sullivan, M. J., Thompson, P. J., Fallen, E. L., Pugsley, S. O., Taylor, D. W., & Berman, L. (1985) · Europe PMC (PubMed Central) · Cited by 2,069
Wisløff, U., Støylen, A., Loennechen, J. P., Bruvold, M., Rognmo, Ø., Haram, P. M., Tjønna, A. E., Helgerud, J., Slørdahl, S. A., Lee, S. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675041 · Cited by 1,996
Nishimura, R. A., & Tajik, A. J. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00144-7 · Cited by 1,257
Celermajer, D. S., Sørensen, K. E., Bull, C., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90141-4 · Cited by 1,228
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Items 301–368 of 368
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Roever, L. (2015) · Translational Medicine · doi:10.4172/2161-1025.1000e134 · Cited by 2
Gong, X., Hu, M., Li, M., & Wang, L. (2022) · BMC Cardiovascular Disorders · doi:10.1186/s12872-022-02792-6 · Cited by 2
Yamazaki, Y., Yabe, H., Sawano, K., Tawara, Y., & Ohgi, S. (2022) · Journal of Physical Therapy Science · doi:10.1589/jpts.34.547 · Cited by 2
Highlights of the Year in JACC 2013
DeMaria, A. N., ADLER, E. D., Bax, J. J., Ben‐Yehuda, O., Feld, G. K., Greenberg, B., Hall, J. L., Hlatky, M. A., Lew, W. Y. W., Lima, J. A. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.002 · Cited by 2
Brubaker, P. H., Tucker, W. J., & Haykowsky, M. J. (2020) · Journal of Clinical Exercise Physiology · doi:10.31189/2165-6193-9.1.17 · Cited by 2
Self-citationThe Role of Exercise-based Cardiac Rehabilitation in Heart Failure
Ong, J. S. Y., Lin, W., & Yeo, T. J. (2023) · Current Pharmaceutical Design · doi:10.2174/1381612829666230217145100 · Cited by 2
Cardoso, F. B., Antunes‐Correa, L. M., Quinaglia, T., Silva, L. M., Toledo, C. D. M., Ribeiro, V. C., Paim, L. R., Neilan, T. G., Velloso, L. A., Nadruz, W., et al. (2019) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622319868376 · Cited by 2
Is physical exercise a protective agent against the way we currently age? A narrative review.
Emilio Jofré, S., Villalobos-Gorigoitía, Á., Hernández, P. A. F., Claudio Farías, V., & Gemma Ea, G. (2021) · Archivos de la Sociedad Chilena de Medicina del Deporte · doi:10.59856/arch.soc.chil.med.deporte.v66i1.24 · Cited by 3
Cavero‐Redondo, I., Martínez‐Rodrigo, A., Otero-Luis, I., Moreno-Herráiz, N., Fenoll-Morante, M., Martínez‐García, I., Guzmán‐Pavón, M. J., & Saz‐Lara, A. (2024) · Applied Sciences · doi:10.3390/app14219642 · Cited by 1
Kılıç-Toprak, E., Tekin, E., Ünver, F., & Bor-Küçükatay, M. (2025) · Pamukkale Journal of Sport Sciences · doi:10.54141/psbd.1599620 · Cited by 1
Determinants of exercise tolerance in HFpEF: role of the heart versus the periphery
Bergeron, N. P., & Reddy, Y. N. V. (2025) · Heart Failure Reviews · doi:10.1007/s10741-025-10545-8 · Cited by 1
Forsyth, F., Hartley, P., Mant, J., Rowbotham, S., Sharpley, J., Wood, A., & Deaton, C. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-096413 · Cited by 1
Samani, S. L., Barlow, S. C., Freeburg, L., Catherwood, G., Churillo, A. M., Jones, T. L., Al-Soudi, J., Ruiz, R., Yigamawano, F. K., Shazly, T. M., et al. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00668.2025 · Cited by 1
DeJong, C., Haywood, C., Erban, J., Cichon, A., Pack, Q. R., Lindenauer, P. K., & Lagu, T. C. (2026) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000001029 · Cited by 1
Yigamawano, F. K., Ruiz, R., Johnson, C. E., Barnette, A., Freeburg, L., Barringhaus, K. G., Spinale, F. G., & Shazly, T. M. (2026) · Journal of Biomechanical Engineering · doi:10.1115/1.4071665 · Cited by 1
Maniscalco, R., Recchioni, R., Caccese, S., Pellegrini, V., Grotta, R. L., Giuliani, A., Pimpini, L., Caraceni, D., Cattadori, G., Passantino, A., et al. (2026) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2026.05.001 · Cited by 1
Liu, F., Wang, Q., Han, S., zhang, M., Bai, X., & Wang, C. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1799035 · Cited by 1
Yang, D. X., Thakur, S., Akunor, H., Stacey, R. B., & Upadhya, B. (2026) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd13070291 · Cited by 1
Pereira, T. C. R., Silva, A. T. F., Mantovani, M. M., Deconte, S. R., Ferreira, B. A., Pinto, M. M. D. G., Lopes, P. R., Menezes, T. M., Fidale, T. M., Maia, Y. C. D. P., et al. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10150-7 · Cited by 1
Bachmann, C. (2015) · Schweizerische Zeitschrift für Ganzheitsmedizin / Swiss Journal of Integrative Medicine · doi:10.1159/000439262 · Cited by 1
Hjertesvikt med normal ejeksjonsfraksjon
Smiseth, O. A., Kjeldsen, S. E., Andersen, Ø. S., Mistry, N., Westheim, A. S., Skulstad, H., & Gude, E. (2019) · Tidsskrift for Den norske legeforening · doi:10.4045/tidsskr.18.0523 · Cited by 1
Aging and Heart Failure With Preserved Ejection Fraction
MacNamara, J. P., Sarma, S., & Levine, B. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-64067-1.00031-0 · Cited by 1
Tolerating Large Preclinical Models of HFpEF But Without the Intolerance?
da Silva, G. J. J., & Bowen, T. S. (2021) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.02.011 · Cited by 1
Ahooghalandary, S. (2022) · مجله علمی پزشکی جندی شاپور · doi:10.32598/jsmj.21.5.2471 · Cited by 1
Caminiti, G., Volterrani, M., Iellamo, F., Marazzi, G., Silvestrini, M., Giamundo, D. M., Morsella, V., Biasio, D. D., Franchini, A., & Perrone, M. A. (2024) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2024.3030 · Cited by 1
Rehabilitation in Heart Failure: Update and New Horizons
Gómez-Cuba, M., de Pinninck-Gaynés, A. P., Planas, R., Manito, N., & González‐Costello, J. (2016) · Current Physical Medicine and Rehabilitation Reports · doi:10.1007/s40141-016-0125-6 · Cited by 1
Troncoso, P. B., & Formiga, F. (2017) · Revista Española de Geriatría y Gerontología · doi:10.1016/j.regg.2017.09.001 · Cited by 1
An Exercise Prescription for Healthy Active Aging
LaBaze, D., Crasto, J. A., & Middleton, K. K. (2018) · Springer eBooks · doi:10.1007/978-3-319-16223-2_16 · Cited by 1
Nguyen, C., Boutron, I., Rören, A., Baron, G., Pauwels, C., Lefèvre‐Colau, M., Poiraudeau, S., Dupeyron, A., Coudeyre, E., & Rannou, F. (2020) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2019.12.006 · Cited by 1
Erhalt von Leistungsfähigkeit und Lebensqualität bei chronischer Herzinsuffizienz (Teil 3)
von Haehling, S., Arzt, M. E., Doehner, W., Edelmann, F., Evertz, R., Ebner, N., Herrmann‐Lingen, C., Garfias‐Veitl, T., Koziolek, M. J., Noutsias, M., et al. (2023) · Die Kardiologie · doi:10.1007/s12181-023-00593-5 · Cited by 1
Heart Failure With Preserved Ejection Fraction
Letnes, J. M., Wisløff, U., & Dalen, H. (2023) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2023.05.026 · Cited by 1
Exercise in Heart Failure: Effectiveness Versus Safety
Russell, S. D. (2015) · Springer eBooks · doi:10.1007/978-3-319-15961-4_9
Kaye, D. M., Shah, S. J., Borlaug, B. A., Gustafsson, F., Komtebedde, J., Kubo, S. H., Magnin, C., Maurer, M. S., Feldman, T. E., & Burkhoff, D. (2014)
中等度強度の定期的有酸素運動が動脈の硬さに与える効果:—圧力—ひずみ弾性率 (Ep) とスティッフネス・パラメータ (β) の超音波測定による評価—
田中, み., 菅原, 基., 小笠原, 康., 泉, 唯., 仁木, 清., & 梶谷, 文. (2015) · 心臓 · doi:10.11281/shinzo.47.157
Staying Young at Heart: A new look at the lifelong benefits of exercise
Berry, J. D. (2015)
Heart Failure with Normal Left Ventricular Ejection Fraction (HFNEF)
Krüger, W. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-54973-6_5
Berckhan, L., Schwan, U., & Wöll, A. (2017) · B&G Bewegungstherapie und Gesundheitssport · doi:10.1055/s-0043-102605
Magalhães, A., Resende, N. M., Ferrari, C. K. B., Fernando, A., Fontes, L., Amador, R., Heredia, G., Espíndola, F. S., & Resende, E. S. (2014)
Iterson, E. H. V., & Olson, T. P. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811279-3.00006-9
Cardiac Rehabilitation in Heart Failure. Part I, Mechanism
Kujawska, A., Husejko, J., Marszałek, A., Szczęśniak, Ż., Topka, W., Gajos, M., Androsiuk-Perkowska, J., Perkowski, R., Skierkowska, N., Kujawski, S., et al. (2018) · Central European Journal of Sport Sciences and Medicine · doi:10.18276/cej.2018.1-02
High Intensity Exercises in Heart Failure with Preserved Ejection Fraction
Herdy, A. H., & Benetti, M. (2018) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20180225
da Costa, M. F. F., Hentschke, V. S., Hentschke, G. S., & Rossato, D. D. (2019) · Fisioterapia Brasil · doi:10.33233/fb.v19i6.2119
Khalil, M. M., Salem, H. M., Abdil-Hamid, H.-E. M., & Zakaria, M. Y. (2019) · Egyptian Journal of Bronchology · doi:10.4103/ejb.ejb_48_19
Exercise and Vascular Function
Kränkel, N., Craenenbroeck, E. M. V., & Adams, V. (2020) · Springer eBooks · doi:10.1007/978-3-030-35374-2_40
Exercise in Specific Diseases: Heart Failure with Preserved Ejection Fraction
Upadhya, B., Edelmann, F., & Kitzman, D. W. (2020) · Springer eBooks · doi:10.1007/978-3-030-35374-2_45
Self-citationTreatment of Heart Failure with Preserved Ejection Fraction
Fedson, S., Misra, A., & Deswal, A. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-60987-6.00039-9
Smart, N. A., Pearson, M. J., Taylor, R. S., & Cleland, J. G. F. (2021) · Journal of Clinical Exercise Physiology · doi:10.31189/2165-7629-10.1.3
Gong, X., Hu, M., Li, M., & Wang, L. (2021) · Research Square · doi:10.21203/rs.3.rs-780863/v1
Physical Training in Heart Failure with Preserved Ejection Fraction
Montenegro, C. E. L., Tavares, D. C. F., Nogueira, F. F., Lyra, A. C. A. D. S., Gomes, T. Q. M., & de Aguiar, M. I. R. (2022) · ABC Heart Failure & Cardiomyopathy · doi:10.36660/abchf.20220064
Müller, S., & Halle, M. (2023) · Springer eBooks · doi:10.1007/978-3-662-65165-0_22
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Al-Zubaidi, D. H., & Hassan, S. (2023) · InnovAiT Education and inspiration for general practice · doi:10.1177/17557380231194230
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Mikić, L., Babić, M., Ristić, A. D., Marković, N., Stojiljković, S., Macura, M., & Popović, D. (2023) · Fizicka kultura · doi:10.5937/fk77-47330
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Umehara, T., Kaneguchi, A., Katayama, N., Kawakami, W., KUWAHARA, D., Kito, N., & Kakehashi, M. (2025) · The National Medical Journal of India · doi:10.25259/nmji_743_2022
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Stahl, M. E., Weeldreyer, N. R., MacNamara, J. P., Lozano, P. F. R., & Allen, J. D. (2025) · Current Cardiology Reports · doi:10.1007/s11886-025-02313-9 · Cited by 1
Fuertes-Kenneally, L., Manresa‐Rocamora, A., Blasco‐Peris, C., Ribeiro, F., Sempere-Ruiz, N., Sarabia, J. M., & Climent, V. E. (2024) · Figshare · doi:10.6084/m9.figshare.26566400
Sugita, Y., Kudo, A., Arakawa, S., & Sakai, S. (2025) · Heart and Vessels · doi:10.1007/s00380-025-02645-0
Liu, T., Li, Q., HUANG, F., Jiang, C., CHENG, Y., Dai, Y., Zhong, H., Ye, Z., Lin, Z., & Wang, F. (2026) · European Journal of Physical and Rehabilitation Medicine · doi:10.23736/s1973-9087.25.09072-0
Enette, L. (2019) · theses.fr (ABES) · doi:10.70675/1ad1a02ez8eebz4234z9bdfzf1e991390f85
Lan, Y., Wu, M., Zhang, S., Xie, Z., Wang, J., Guo, J., & Xiong, W. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-026-05787-9
Henríquez-Jurado, J. M., Fuentes-Abolafio, I. J., García-Conejo, C., & Cuesta‐Vargas, A. (2026) · Brazilian Journal of Physical Therapy · doi:10.1016/j.bjpt.2026.101596
Shi, X., Liu, F., Song, R., Guo, X., Huang, J., Chen, J., & Gao, H. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1838821
Guimarães, G. V., d’Avila, V. M., Chizzola, P. R., Álvarez, C., & Bocchi, E. A. (2026) · Clinics · doi:10.1016/j.clinsp.2026.101142
Iskra, S., & Paravlic, A. H. (2026) · Annales Kinesiologiae · doi:10.35469/ak.2026.558
Iskra, S., Turnšek, G., Drole, K., & Paravlic, A. H. (2026) · Sports Medicine - Open · doi:10.1186/s40798-026-01110-0
Turnšek, G., & Paravlic, A. H. (2026) · Sport Sciences for Health · doi:10.1007/s11332-026-01976-3
Tavakoli, K., Ansari, A., Alaei, E., Jahanfard, R., Mansouri, E. S., Ganjalikhani, M., Selk-Ghaffari, M., Shahi, M. H. P., & Memari, A. H. (2026) · Journal of Cardiology · doi:10.1016/j.jjcc.2026.10.004
Metadata
- Authors
- Kitzman, D. W., Brubaker, P. H., Herrington, D. M., Morgan, T. M., Stewart, K. P., Hundley, W. G., Abdelhamed, A., & Haykowsky, M. J.
- Affiliations
- Wake Forest University Health Sciences (US)
- Wake Forest University (US)
- Wright State University (US)
- University of Alberta (CA)
- Corresponding author
- Kitzman, Dalane W.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 62
- Issue
- 7
- Pages
- 584-592
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC3740089
- OpenAlex
- W113644040
- Cited by
- 369
- References
- 69
- Citations by year
- 2026: 19 · 2025: 23 · 2024: 21 · 2023: 33 · 2022: 39 · 2021: 32 · 2020: 18 · 2019: 30 · 2018: 25 · 2017: 35 · 2016: 24 · 2015: 32 · 2014: 31 · 2013: 7
- FWCI
- 74.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R37AG18915, R01AG12257, and P30AG021332)
- Novartis
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- heart failure with preserved ejection fraction, endurance training, endothelial function, flow-mediated dilation, arterial stiffness, carotid distensibility, older adults, quality of life, left ventricular function, skeletal muscle perfusion, ergometry, attentional control
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Angiography, Carotid Arteries, Endothelium, Vascular, Exercise Therapy, Female, Follow-Up Studies, Heart Failure, Humans, Male, Oxygen Consumption, Prospective Studies, Quality of Life, Reference Values, Severity of Illness Index, Stroke Volume, Ultrasonography, Single-Blind Method, Ventricular Function, Left, Treatment Outcome, Exercise Tolerance, Risk Assessment, Vascular Stiffness
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