Cited by 208Atrial Fibrillation Management and OutcomesHeart Failure Treatment and ManagementPharmaceutical Practices and Patient Outcomes

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

Increased Mortality Associated With Digoxin in Contemporary Patients With Atrial Fibrillation

Open access

Turakhia, Mintu P., Santangeli, Pasquale, Winkelmayer, Wolfgang C., Xu, Xiangyan, Ullal, Aditya J., Than, Claire T., Schmitt, Susan, Holmes, Tyson H., Frayne, Susan M., Phibbs, Ciaran S., Yang, Felix, Hoang, Donald D., Ho, P. Michael, Heidenreich, Paul A.·2014·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2014.03.060PMC PMC4405246

Open this paper in CoChat — free account Open PDF

Abstract

Background Despite endorsement of digoxin in clinical practice guidelines, there exist limited data on its safety in atrial fibrillation/flutter (AF).Objectives The goal of this study was to evaluate the association of digoxin with mortality in AF.Methods Using complete data of the TREAT-AF (The Retrospective Evaluation and Assessment of Therapies in AF) study from the U.S. Department of Veterans Affairs (VA) healthcare system, we identified patients with newly diagnosed, nonvalvular AF seen within 90 days in an outpatient setting between VA fiscal years 2004 and 2008. We used multivariate and propensity-matched Cox proportional hazards to evaluate the association of digoxin use with death. Residual confounding was assessed by sensitivity analysis.Results Of 122,465 patients with 353,168 person-years of follow-up (age 72.1 ± 10.3 years, 98.4% male), 28,679 (23.4%) patients received digoxin. Cumulative mortality rates were higher for digoxin-treated patients than for untreated patients (95 vs. 67 per 1,000 person-years; p < 0.001). Digoxin use was independently associated with mortality after multivariate adjustment (hazard ratio [HR]: 1.26, 95% confidence interval [CI]: 1.23 to 1.29, p < 0.001) and propensity matching (HR: 1.21, 95% CI: 1.17 to 1.25, p < 0.001), even after adjustment for drug adherence. The risk of death was not modified by age, sex, heart failure, kidney function, or concomitant use of beta-blockers, amiodarone, or warfarin.Conclusions Digoxin was associated with increased risk of death in patients with newly diagnosed AF, independent of drug adherence, kidney function, cardiovascular comorbidities, and concomitant therapies. These findings challenge current cardiovascular society recommendations on use of digoxin in AF.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2014.03.060

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A New Equation to Estimate Glomerular Filtration Rate
Levey, A. S., Stevens, L. A., Schmid, C. H., Zhang, Y. (., Castro, A. F., Feldman, H. I., Kusek, J. W., Eggers, P., Van Lente, F., Greene, T., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-9-200905050-00006 · Cited by 25,603
Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data
Quan, H., Sundararajan, V., Halfon, P., Fong, A., Burnand, B., Luthi, J.-C., Saunders, L. D., Beck, C. A., Feasby, T. E., & Ghali, W. A. (2005) · Medical Care · doi:10.1097/01.mlr.0000182534.19832.83 · Cited by 10,669
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,954
Validation of Clinical Classification Schemes for Predicting Stroke: Results From the National Registry of Atrial Fibrillation
Gage, B. F., Waterman, A. D., Shannon, W., Boechler, M., Rich, M. W., & Radford, M. J. (2001) · JAMA · doi:10.1001/jama.285.22.2864 · Cited by 4,832
The effect of digoxin on mortality and morbidity in patients with heart failure
(1997) · New England Journal of Medicine · doi:10.1056/nejm199702203360801 · Cited by 3,016
Relationships Between Sinus Rhythm, Treatment, and Survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study
The AFFIRM Investigators (2004) · Circulation · doi:10.1161/01.cir.0000121736.16643.11 · Cited by 1,202
Measurement of Adherence in Pharmacy Administrative Databases: A Proposal for Standard Definitions and Preferred Measures
Hess, L. M., Raebel, M. A., Conner, D. A., & Malone, D. C. (2006) · Annals of Pharmacotherapy · doi:10.1345/aph.1h018 · Cited by 778
Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure
Rathore, S. S., Curtis, J. P., Wang, Y., Bristow, M. R., & Krumholz, H. M. (2003) · JAMA · doi:10.1001/jama.289.7.871 · Cited by 772
Assessing the sensitivity of regression results to unmeasured confounders in observational studies
Lin, D. Y., Psaty, B. M., & Kronmal, R. A. (1998) · Biometrics · doi:10.2307/2533848 · Cited by 742
Statistical power analysis for the behavioral sciences
Sockloff, A. L. (1978) · Evaluation and Program Planning · doi:10.1016/0149-7189(78)90080-0 · Cited by 715

Show all 31 references

Sorted by citations

Items 101–200 of 208

The impact of serum concentration‐guided digoxin therapy on mortality of heart failure patients: A long‐term follow‐up, propensity‐matched cohort study
Muk, B., Vámos, M., Bógyi, P., Szabo, B. A., Dékány, M., Vágány, D., Majoros, Z., Borsányi, T., Duray, G. Z., Kiss, R. G., et al. (2020) · Clinical Cardiology · doi:10.1002/clc.23500 · Cited by 10
Concurrent renal dysfunction with ischemic heart disease is an important determinant for cardiac and cerebrovascular mortality in patients on chronic digoxin therapy for atrial fibrillation
Shin, J. H., Kang, K., Kim, J. G., & Lee, S. J. (2018) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.2018.37.2.130 · Cited by 10
Atrial fibrillation in Europe: state of the state in disease management!
Pillarisetti, J., & Lakkireddy, D. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu415 · Cited by 10
Association of CHA2DS2-VASc and HAS-BLED to frailty and frail outcomes: From the TREAT-AF study
Pundi, K. N., Perino, A. C., Fan, J., Din, N., Szummer, K. E., Heidenreich, P. A., & Turakhia, M. P. (2023) · American Heart Journal · doi:10.1016/j.ahj.2023.03.015 · Cited by 9
Self-citation
Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data
Hirai, T., Kasai, H., Naganuma, M., Hagiwara, N., & Shiga, T. (2022) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-022-00552-y · Cited by 9
Pharmacological Therapy for Rate and Rhythm Control for Atrial Fibrillation in 2017
Kanagaratnam, L. B., Kowey, P. R., & Whalley, D. W. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.05.134 · Cited by 10
Digitalis therapy is associated with higher comorbidities and poorer prognosis in patients undergoing ablation of atrial arrhythmias: data from the German Ablation Registry
Frommeyer, G., Brachmann, J., İnce, H., Spitzer, S. G., Thomas, D., Willems, S., Schumacher, B. M., Schirdewahn, P., Lewalter, T., Hochadel, M., et al. (2019) · Clinical Research in Cardiology · doi:10.1007/s00392-019-01442-w · Cited by 8
Atrial fibrillation and hypertension: current understanding of the pathogenesis, diagnosis, and treatment
Kirgizova, M. A., Batalov, R. E., Tatarsky, B. A., & Popov, S. V. (2019) · Сибирский журнал клинической и экспериментальной медицины · doi:10.29001/2073-8552-2019-34-3-13-20 · Cited by 8
Current pharmacotherapeutic strategies for cardiac arrhythmias in heart failure
Correa, A. A., Rochlani, Y. M., & Aronow, W. S. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1703950 · Cited by 8
Atrial fibrillation in patients with systolic heart failure: pathophysiology mechanisms and management.
Koniari, I. C., Artopoulou, E., Velissaris, D., Kounis, N. G., & Tsigkas, G. (2021) · PubMed Central · doi:10.11909/j.issn.1671-5411.2021.05.003 · Cited by 8
Predictors of digoxin use and risk of mortality in ED patients with atrial fibrillation
Wu, S., Yang, Y., Zhu, J., Ren, J., Wang, J., Zhang, H., & Shao, X. (2017) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2017.04.070 · Cited by 8
Digitalis Glycosides for Heart Rate Control in Atrial Fibrillation
Curfman, G. (2020) · JAMA · doi:10.1001/jama.2020.24578 · Cited by 8
Optimizing Growth Conditions for Digoxin Production in Digitalis lanata Ehrh
van Wietmarschen, H., Hagels, H., Peters, R., Heistek, J., van der Greef, J., & Wang, M. (2016) · World Journal of Traditional Chinese Medicine · doi:10.15806/j.issn.2311-8571.2016.0010 · Cited by 7
Effect of Digoxin Use Among Medicaid Enrollees With Atrial Fibrillation
Adedinsewo, D. A., Xu, J., Agasthi, P., Oderinde, A., Adekeye, O. A., Sachdeva, R., Rust, G. S., & Onwuanyi, A. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.116.004573 · Cited by 7
Chronic digitalis therapy in patients before heart transplantation is an independent risk factor for increased posttransplant mortality
Rivinius, R., Helmschrott, M., Ruhparwar, A., Rahm, A., Darche, F. F., Thomas, D., Bruckner, T., Ehlermann, P., Katus, H. A., & Doesch, A. O. (2017) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s147062 · Cited by 7
SUDDEN CARDIAC DEATH IN 21,105 PATIENTS WITH ATRIAL FIBRILLATION: INSIGHTS FROM THE ENGAGE AF- TIMI 48 TRIAL
Eisen, A., Ruff, C. T., Nordio, F., Corbalan, R. L., Dalby, A. J., Dorobanţu, M., Mercuri, M. F., Lanz, H., Rutman, H., Antman, E. M., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(16)30790-2 · Cited by 7
Outcomes With Digoxin in Atrial Fibrillation
Reynolds, M. R. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.04.070 · Cited by 7
Influence of digoxin on mortality in patients with atrial fibrillation: Overview of systematic reviews
Baker, W. L., Sobieraj, D. M., & DiDomenico, R. J. (2021) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2510 · Cited by 6
Relationships among achieved heart rate, β-blocker dose and long-term outcomes in patients with heart failure with atrial fibrillation
Miller, R. J. H., Howlett, J. G., Chiu, M. H., Southern, D. A., Knudtson, M. L., & Wilton, S. B. (2016) · Open Heart · doi:10.1136/openhrt-2016-000520 · Cited by 6
Impact of Digitalis Use on Mortality in Japanese Patients With Non-Valvular Atrial Fibrillation ― A Subanalysis of the J-RHYTHM Registry ―
Kodani, E., Inoue, H., Atarashi, H., Okumura, K., Yamashita, T., Origasa, H., & on behalf of the J-RHYTHM Registry Investigators (2019) · Circulation Journal · doi:10.1253/circj.cj-19-0267 · Cited by 6
Clinical outcomes with digoxin vs. beta‐blocker for heart rate control in permanent atrial fibrillation with heart failure
Bisson, A., Ding, W. Y., Bodin, A., Lip, G. Y. H., & Fauchier, L. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2292 · Cited by 6
Digoxin in Atrial Fibrillation?
Turakhia, M. P. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.01.015 · Cited by 6
Self-citation
Pharmacologic Rate versus Rhythm Control for Atrial Fibrillation in Heart Failure Patients
Koniari, I. C., Artopoulou, E., Velissaris, D., Mplani, V., Anastasopoulou, M., Kounis, N. G., GREGORIO, C. D., Tsigkas, G., Karunakaran, A., Plotas, P., et al. (2022) · Medicina · doi:10.3390/medicina58060743 · Cited by 5
Atrial fibrillation fact sheet in Korea 2024 (part 3): treatment for atrial fibrillation in Korea: medicines and ablation
Kim, Y. G., Lee, K., Baek, Y., Kim, B., Han, K., Park, H., Ahn, J., Park, J., & Shim, J. (2024) · International Journal of Arrhythmia · doi:10.1186/s42444-024-00122-9 · Cited by 5
Digoxin Use in Atrial Fibrillation; Insights From National Ambulatory Medical Care Survey
Anwar, M. N., Khan, U. A., Khakwani, A. S., Saeed, I., Ishfaq, H., Muslim, M. O., & Anwaar, M. F. (2022) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2022.101209 · Cited by 5
Prognostic factors of clinical endpoints in elderly patients with atrial fibrillation during a 2-year follow-up in China
Wang, H., Wang, H., Chen, Y.-D., Tao, T., Guo, Y., Zhao, X., Liu, H.-B., & Wang, Y. (2017) · Medicine · doi:10.1097/md.0000000000007679 · Cited by 5
Foundations of Pharmacotherapy for Heart Failure With Reduced Ejection Fraction
McIlvennan, C. K., & Page, R. L., II (2016) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000335 · Cited by 5
Association Between Digoxin Use and Adverse Outcomes Among Patients in the Chinese Atrial Fibrillation Registry
Gao, Y., Chang, S., Du, X., Dong, J., Xu, X., Zhou, Y., Lip, G. Y. H., & Ma, C. (2019) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-019-00350-8 · Cited by 4
Self-citation
Dronedarone Versus Sotalol in Antiarrhythmic Drug–Naive Veterans With Atrial Fibrillation
Pundi, K. N., Fan, J., Kabadi, S., Din, N., Blomström‐Lundqvist, C., Camm, A. J., Kowey, P. R., Singh, J. P., Rashkin, J., Wieloch, M., et al. (2023) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.123.011893 · Cited by 4
Self-citation
Atrial fibrillation management: evaluating rate vs rhythm control
Nguyen, T. L., Jolly, U. S., Sidhu, K., Yee, R. K., & Leong‐Sit, P. (2016) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2016.1164033 · Cited by 4
Peculiarities of therapy for heart rhythm disorders in patients with chronic heart failure
Tarlovskaya, E. I. (2017) · Kardiologiia · doi:10.18087/cardio.2391 · Cited by 4
Incidence and outcomes of patients with atrial fibrillation and major bleeding complications: from the TREAT-AF study
Perino, A. C., Kaiser, D. W., Lee, R. J., Fan, J., Askari, M., Schmitt, S. K., & Turakhia, M. P. (2020) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-020-00873-0 · Cited by 4
Self-citation
Is There Still a Role for Digoxin in the Management of Atrial Fibrillation?
Washam, J. B., & Patel, M. R. (2018) · Current Cardiology Reports · doi:10.1007/s11886-018-1047-y · Cited by 4
Does Left Ventricular Systolic Function Matter? Treating Atrial Fibrillation in HFrEF Versus HFpEF
Stokes, M. B., & Sanders, P. (2019) · Cardiology Clinics · doi:10.1016/j.ccl.2019.01.008 · Cited by 4
Digoxin
Dardas, T., & Levy, W. C. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.04.044 · Cited by 4
Role for digoxin in patients hospitalized with COVID‐19 and atrial arrhythmias
Peltzer, B., Lerman, B. B., Goyal, P., & Cheung, J. W. (2021) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.14901 · Cited by 4
Reconsidering Digoxin in Atrial Fibrillation: From Historical Controversy to Physiologically Guided and Personalized Rate Control
Luca, S. A., Faur-Grigori, A. A., Văcărescu, C., Cozma, D. C., Crișan, S., Gaiță, D. I., Lazăr, M.-A., & Luca, C. T. (2025) · Biomedicines · doi:10.3390/biomedicines13123098 · Cited by 4
Foundations of Pharmacotherapy for Heart Failure With Reduced Ejection Fraction
Paul, S. C., & Page, R. L., II (2015) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000284 · Cited by 3
Characteristics and Treatment of Atrial Fibrillation with Respect to the Presence or Absence of Heart Failure. Insights from the Multicenter Polish Atrial Fibrillation (POL-AF) Registry
Gawalko, M. M., Budnik, M., Gorczyca−Michta, I., Jelonek, O. E., Uziębło‐Życzkowska, B., Maciorowska, M., Wójcik, M., Błaszczyk, R. T., Tokarek, T., Rajtar-Salwa, R., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071341 · Cited by 3
Evaluating the Adherence to Guidelines for Management of Acute Heart Failure in the Gaza Strip Hospitals: A Medical Chart–Based Review Study
Elshami, M., Dabbour, R. S., Alkhatib, M., Abdalghafoor, T., Alaloul, E., Habib, M., Ismail, M., & Böttcher, B. (2019) · Global Journal on Quality and Safety in Healthcare · doi:10.4103/jqsh.jqsh_21_18 · Cited by 3
The year in cardiovascular medicine 2021: arrhythmias
Crijns, H. J. G. M., Sanders, P., Albert, C. M., & Lambiase, P. D. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac007 · Cited by 3
Atrial Fibrillation
Issa, Z. F., Miller, J. M., & Zipes, D. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-52356-1.00015-3 · Cited by 3
Warfarin Time in Therapeutic INR Range and Direct Oral Anticoagulant Adherence for Venous Thromboembolism Across the Spectrum of Weight and Body Mass Index: Findings from Veterans Health Administration
Din, N., Fan, J., Schmitt, S. K., Guo, J. D., Hlavacek, P. R., Pundi, K. N., Russ, C., Emir, B., Turakhia, M. P., & Perino, A. C. (2023) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296231152474 · Cited by 3
Self-citation
Detection of Adverse Reaction to Drugs in Elderly Patients through Predictive Modeling
Carrasco, R. S.-M. (2016) · International Journal of Interactive Multimedia and Artificial Intelligence · doi:10.9781/ijimai.2016.368 · Cited by 3
Gaps in the Heart Failure Guidelines
Tran, B. G., & Fonarow, G. C. (2015) · Cardiac failure review · doi:10.15420/cfr.2015.01.01.50 · Cited by 3
Other Antiarrhythmic Drugs
Tamargo, J. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-34893-9_6 · Cited by 3
A pharmacokinetic study of digoxin holiday dosing practice in Egypt: A prospective-randomized trial
Shabasy, S. A. A., Abbassi, M., Mohamed, M., & Farid, S. F. (2016) · Bulletin of Faculty of Pharmacy Cairo University · doi:10.1016/j.bfopcu.2016.04.004 · Cited by 3
The Care of Patients With Atrial Fibrillation and Heart Failure
Abbasi, M. H., Maan, A., & Heist, E. K. (2020) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0000000000000235 · Cited by 3
Association of Race and Ethnicity With Stroke and Mortality Outcomes in Atrial Fibrillation
Essien, U. R., Tang, J., Kim, N., Hausmann, L. R. M., Washington, D. L., Mor, M. K., Nguyen, V. P., Magnani, J. W., Gellad, W. F., & Fine, M. J. (2025) · JACC Advances · doi:10.1016/j.jacadv.2025.101860 · Cited by 2
2018 Korean Heart Rhythm Society Guidelines for The Rate Control of Atrial Fibrillation
Lim, W., Choi, E., Joung, B., & Choi, K. (2018) · Korean Journal of Medicine · doi:10.3904/kjm.2018.93.2.133 · Cited by 2
Modified SAMe-TT2R2 score for predicting the therapeutic range of digoxin
Karataş, M. B., Çanga, Y., Yelgeç, N. S., Zengin, A., Güzelburç, Ö., Eren, S., & Emre, A. (2020) · Herz · doi:10.1007/s00059-020-04965-5 · Cited by 2
Atrial fibrillation bleeding risk and prediction while treated with direct oral anticoagulants in warfarin‐naïve or warfarin‐experienced patients
Perino, A. C., Fan, J., Pundi, K. N., Schmitt, S. K., Kothari, M., Din, N., Heidenreich, P. A., & Turakhia, M. P. (2022) · Clinical Cardiology · doi:10.1002/clc.23887 · Cited by 2
Self-citation
The Bad Reputation of Digoxin in Atrial Fibrillation—Causality or Bias? Nationwide Nested Case-Control Study
Holt, A., Strange, J. E., Hansen, M. L., Lamberts, M., & Rasmussen, P. V. (2025) · American Journal of Medicine Open · doi:10.1016/j.ajmo.2025.100093 · Cited by 2
Gaps in the Heart Failure Guidelines
Tran, B. G., & Fonarow, G. C. (2014) · European Cardiology Review · doi:10.15420/ecr.2014.9.2.104 · Cited by 2
Evaluation of Safety and Efficacy of Intravenous Digoxin Loading Doses Based on Ideal Body Weight
Clark, J. L., Jacobs, J. A., Watanabe, A. H., Catino, A. B., & Dechand, J. (2023) · Annals of Pharmacotherapy · doi:10.1177/10600280221146530 · Cited by 2
Utilization of Digoxin among Hospitalized Older Patients with Heart Failure and Atrial Fibrillation in Thailand: Prevalence, Associated Factors, and Clinical Outcomes
Singkham, N., Wongsalap, Y., Poolpun, D., Phetnoo, S., & Somkhon, C. (2021) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.21.0098 · Cited by 2
Reply
Turakhia, M. P., & Heidenreich, P. A. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.10.032 · Cited by 2
Self-citation
Resting heart rate, functional capacity and prognosis in heart failure patients: atrial fibrillation versus sinus rhythm
Moreira, R. I., da Silva, T. P., Gonçalves, A. V., Feliciano, J., Rio, P., Soares, R., & Ferreira, F. (2019) · International Physical Medicine & Rehabilitation Journal · doi:10.15406/ipmrj.2019.04.00187 · Cited by 1
Strategy for the Prediction of Steady-State Exposure of Digoxin to Determine Drug–Drug Interaction Potential of Digoxin With Other Drugs in Digitalization Therapy
Srinivas, N. R. (2016) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000435 · Cited by 1
Optimizing therapy in patients with atrial fibrillation and heart failure
Mulder, B. A. (2015) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 1
Effects of Age, Gender, and Comorbid Diseases on Serum Digoxin Levels During Digoxin Treatment
Izmir Ataturk Egitim ve Arastirma Hastanesi, K. F. V. T. B., Ozturk, Z., ÇUHADAR, S., & Izmir Ataturk Egitim ve Arastirma Hastanesi, T. B. L. (2017) · Bezmialem Science · doi:10.14235/bs.2017.1383 · Cited by 1
Fibrilación auricular e insuficiencia cardíaca
Tortajada, G., Caorsi, W. R., & Varela, G. (2017) · Revista Uruguaya de Cardiología · doi:10.29277/ruc/32.3.14 · Cited by 1
Atrial arrhythmias in heart failure with a reduced ejection fraction
Dewland, T. A., & Nazer, B. (2020) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000734 · Cited by 1
What Interventions Are Effective for Managing Dyspnea in Heart Failure?
Avant, L. C., Dionne-Odom, J. N., & Swetz, K. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-84702-5.00017-8 · Cited by 1
Different rate-controlling agents for the management of atrial fibrillation with rapid ventricular rate in the emergency department: a network meta-analysis
Ibrahim, I., Kuan, W. S., Yau, Y. W., Chua, M. T., Lin, Z., Cheng, L. T. W., Zheng, Q., Shi, L., Samuel, M., de Souza, N. N., et al. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013642 · Cited by 1
Association of digoxin therapy with case fatality rate in acute pulmonary embolism
Karataş, M. B., Yelgeç, N. S., Çanga, Y., Zengin, A., & Emre, A. (2020) · Wiener klinische Wochenschrift · doi:10.1007/s00508-020-01773-z · Cited by 1
β blockers in patients with heart failure and atrial fibrillation
Shah, R. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60788-7 · Cited by 1
Heart Failure (Stages A, B and C)
Le, D. D., Le, T. H., Viêt, V. M., Ho, B. V., Nguyen, T. D., Azza, K. N. A., Tran, H. V., & Rigatelli, G. (2016) · Wiley eBooks · doi:10.1002/9781118965061.ch6 · Cited by 1
Gender and atrial fibrillation: revisiting its role in integrated ABC pathway management
Mulia, E. P. B. (2022) · Heart and Vessels · doi:10.1007/s00380-022-02168-y · Cited by 1
Response to “Digoxin or digoxin prescribed patient? Randomized trials are essential to discriminate the principal risk factor for the association of digoxin and increased mortality”
Pastori, D., Farcomeni, A., Bucci, T., Cangemi, R., Ciacci, P., Vicario, T., Violi, F., & Pignatelli, P. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.125
Digoxin use in atrial fi brillation: a critical reappraisal
Hughes, D. A., & Pastores, G. M. (2015)
Treatment of Atrial Fibrillation and Atrial Flutter
Christ, T., Pecha, S., & Jost, N. (2015) · Springer eBooks · doi:10.1007/978-3-319-15961-4_50
Uso de digoxina en pacientes con fibrilación auricular y resultados cardiovasculares adversos: un análisis retrospectivo de rivaroxabán oral directo del factor Xa inhibición una vez al día en comparación con el antagonismo de la vitamina K para la prevención del ictus y de la embolia en la fibrilación auricular (ROCKET AF)
Divisón, J. A., & Cervantes, C. E. (2015) · Medicina de Familia SEMERGEN · doi:10.1016/j.semerg.2015.08.008
Digoxin Associated with Elevated Mortality in Atrial Fibrillation Patients
Fleischmann, K. E., & Krumholz, S. H. M. (2014) · Journal watch · doi:10.1056/nejm-jw.na35708
Safety of digoxin use in patients with hypertensive heart disease and atrial fibrillation
Kahan, T. (2015) · Journal of Hypertension · doi:10.1097/hjh.0000000000000628
Outpatient Medications in Atrial Fibrillation
Newby, L. K., & Pokorney, S. D. (2016) · Contemporary cardiology · doi:10.1007/978-3-319-31386-3_18
Is Heart Rate a Norepiphenomenon in Heart Failure?
Hensey, M., & O’Neill, J. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0764-3
Increased Mortality by Digoxin in Patients With Atrial Fibrillation?
de Boer, A. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.081
Transcatheter Ablation of Atrial Fibrillation in Patients with Chronic Heart Failure
Monaco, A. D., Quadrini, F., Vitulano, N., & Grimaldi, M. (2017) · InTech eBooks · doi:10.5772/67024
Typical atrial flutter
Miller, J. M., Das, M. K., & Zipes, D. P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-18772-5.00021-3
Editor-in-Chief's Picks From 2014: Part One
Fuster, V. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.12.021
Fibrilación auricular y flúter auricular
Valverde-Gómez, M., Granero, C. L., Muñoz, D. R., & Gómez, J. L. Z. (2017) · Medicine - Programa de Formación Médica Continuada Acreditado · doi:10.1016/j.med.2017.07.010
Positive Inotropic Drugs and Drugs Used in Dysrhythmias
Maynard, C., & Fan, J. (2015) · Side effects of drugs annual · doi:10.1016/bs.seda.2015.06.011
Positive Inotropic Drugs and Drugs Used in Dysrhythmias
Maynard, C., & Fan, J. (2016) · Side effects of drugs annual · doi:10.1016/bs.seda.2016.07.009
The Arrhythmia Patient in the CCU – Impact of Echocardiography
Sugrue, A. M., Bhatia, S., Vaidya, V., & Asirvatham, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-90278-4_3
Digoxin gefährlicher als gedacht?
Pannu, A. (2019) · Der Kardiologe · doi:10.1007/s12181-019-0304-7
Pharmacotherapy in Heart Failure (I): Renin-Angiotensin-Aldosterone System (incl. ARNI), Diuretics, Digoxin and Statins
Rocca, H. B. (2019) · Cardiovascular medicine · doi:10.1007/978-3-319-98184-0_7
Does digoxin cause more harm than good?
Reed, G. (2019) · Journal of Paramedic Practice · doi:10.12968/jpar.2019.11.4.165
¿Hay un nuevo fármaco disponible para el control de la frecuencia cardiaca de pacientes con fibrilación auricular permanente?
Rivas‐Gándara, N., & Pascual, J. F. (2020) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.07.002
Do we have a new drug for heart rate control in patients with permanent atrial fibrillation?
Rivas‐Gándara, N., & Pascual, J. F. (2020) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2020.07.013
Association of kidney function and atrial fibrillation progression to clinical outcomes in patients with cardiac implantable electronic devices
Szummer, K. E., Pundi, K. N., Perino, A. C., Fan, J., Kothari, M., & Turakhia, M. P. (2021) · American Heart Journal · doi:10.1016/j.ahj.2021.06.002
Self-citation
Editor-in-Chief's Picks From 2014: Part Two
Fuster, V. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.12.022
Introduction
Holmes, W. H., & Rinaman, W. C. (2014) · Springer eBooks · doi:10.1007/978-3-319-12550-3_1
Typical Atrial Flutter
Issa, Z. F., Miller, J. M., & Zipes, D. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-52356-1.00012-8
Digoxin increases mortality in patients with AF
(2014) · Reactions Weekly · doi:10.1007/s40278-014-2890-2
Investigation of the relationship of frontal QRS-T angle and digoxin use and blood digoxin level
ZENGİN, İ., & Uğuz, B. (2022) · The European Research Journal · doi:10.18621/eurj.1144126
Association of digoxin with mortality and rehospitalization in heart failure patients treated with beta-blockers: Results from the Persian Heart Failure Patient Registry.
Yazdi, M., Shafie, D., Givi, M., Garakyaraghi, M., Sarrafzadegan, N., & Yadegarfar, G. (2022) · PubMed Central · doi:10.48305/arya.v18i0.2329
Is inhibition of If in the atrioventricular node to control ventricular rate during atrial fibrillation ready for prime time?
Verrier, R. L., Maher, T. R., Kreidieh, B., & d’Ávila, A. (2023) · Heart Rhythm · doi:10.1016/j.hrthm.2023.02.032
Exploring the association between atrial fibrillation and celiac disease: a comprehensive review
Subedi, R., Soulat, A., Butt, S. R., Mohan, A., Butt, M. D., Arwani, S., Ahmed, G., Majumder, K., Lal, P. M., Kumar, V., et al. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002259
Multitarget Autonomic Acting Drugs
Dan, A. R., Martínez‐Rubio, A., & Buzea, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-74046-6_7

Authors: Turakhia, M. P., Santangeli, P., Winkelmayer, W. C., Xu, X., Ullal, A. J., Than, C. T., Schmitt, S., Holmes, T. H., Frayne, S. M., Phibbs, C. S., Yang, F., Hoang, D. D., Ho, P. M., & Heidenreich, P. A.
Affiliations: VA Palo Alto Health Care System (US)
Stanford Medicine (US)
Maimonides Medical Center (US)
VA Eastern Colorado Health Care System (US)
Corresponding author: Turakhia, Mintu P.
ORCID: Turakhia, Mintu P.
Santangeli, Pasquale
Than, Claire T.
Holmes, Tyson H.
Frayne, Susan M.
Phibbs, Ciaran S.
Yang, Felix
Ho, P. Michael
Heidenreich, Paul A.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2014-08
Volume: 64
Issue: 7
Pages: 660-668
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2014.03.060
PMC: PMC4405246
OpenAlex: W2157998686
Cited by: 208
References: 31
Citations by year: 2026: 4 · 2025: 6 · 2024: 4 · 2023: 9 · 2022: 12 · 2021: 18 · 2020: 17 · 2019: 19 · 2018: 11 · 2017: 21 · 2016: 37 · 2015: 41 · 2014: 9
FWCI: 24.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Heart Association (09SDG2250647, CDA09027-1)
Amgen
GlaxoSmithKline
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK095024)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords: digoxin, atrial fibrillation, mortality, drug safety, newly diagnosed atrial fibrillation, non-valvular atrial fibrillation, medication adherence, veterans, propensity score matching, beta-blockers, amiodarone, warfarin
MeSH terms: Aged, Anti-Arrhythmia Agents, Atrial Fibrillation, Cause of Death, Digoxin, Female, Follow-Up Studies, Humans, Male, Outpatients, Prognosis, Retrospective Studies, Risk Factors, United States, Survival Rate, Confidence Intervals, Proportional Hazards Models, Risk Assessment, Propensity Score

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased Mortality Associated With Digoxin in Contemporary Patients With Atrial Fibrillation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks