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Cited by 143Cardiovascular Function and Risk FactorsBlood Pressure and Hypertension StudiesCardiovascular Health and Disease Prevention

Cumulative Blood Pressure in Early Adulthood and Cardiac Dysfunction in Middle Age

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Kishi, Satoru, Teixido-Tura, Gisela, Ning, Hongyan, Venkatesh, Bharath Ambale, Wu, Colin, Almeida, Andre, Choi, Eui-Young, Gjesdal, Ola +5 more·2015·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2015.04.042
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Abstract

Background Cumulative blood pressure (BP) exposure may adversely influence myocardial function, predisposing individuals to heart failure later in life. Objectives This study sought to investigate how cumulative exposure to higher BP influences left ventricular (LV) function during young to middle adulthood. Methods The CARDIA (Coronary Artery Risk Development in Young Adults) study prospectively enrolled 5,115 healthy African Americans and whites in 1985 and 1986 (baseline). At the year 25 examination, LV function was measured by 2-dimensional echocardiography; cardiac deformation was assessed in detail by speckle-tracking echocardiography. We used cumulative exposure of BP through baseline and up to the year 25 examination (millimeters of mercury × year) to represent long-term exposure to BP levels. Linear regression and logistic regression were used to quantify the association of BP measured repeatedly through early adulthood (18 to 30 years of age) up to middle age (43 to 55 years). Results Among 2,479 participants, cumulative BP measures were not related to LV ejection fraction; however, high cumulative exposure to systolic blood pressure (SBP) and diastolic blood pressure (DBP) were associated with lower longitudinal strain rate (both p < 0.001). For diastolic function, higher cumulative exposures to SBP and DBP were associated with low early diastolic longitudinal peak strain rate. Of note, higher DBP (per SD increment) had a stronger association with diastolic dysfunction compared with SBP. Conclusions Higher cumulative exposure to BP over 25 years from young adulthood to middle age is associated with incipient LV systolic and diastolic dysfunction in middle age.

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  • The CARDIA study and ARIC cohort indicate that people with high cumulative systolic BP over many years have worse cardiac function and higher risk of incident heart failure later in life than those with lower cumulative systolic BP.

    “Mounting evidence, including data from the CARDIA study27 and the ARIC cohort28, indicates that individuals with high cumulative systolic BP levels over many years have worse cardiac function and increased risk of incident heart failure in later life compared with individuals with lower cumulative systolic BP levels.”

    From Blood pressure and its variability: classic and novel measurement techniques (2022) · cites this paper as [27]

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Authors
Kishi, S., Teixido-Tura, G., Ning, H., Venkatesh, B. A., Wu, C., Almeida, A., Choi, E.-Y., Gjesdal, O., Jacobs, D. R., Schreiner, P. J., Gidding, S. S., Liu, K., & Lima, J. A. C.
Affiliations
  • Johns Hopkins University (US)
  • Northwestern University (US)
  • National Heart, Lung, and Blood Institute (US)
  • University of Minnesota (US)
  • Alfred I. duPont Hospital for Children (US)
Corresponding author
Lima, João A.C.
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2015-06
Volume
65
Issue
25
Pages
2679-2687
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2015.04.042
OpenAlex
W2238977382
Cited by
143
References
48
Citations by year
2026: 6 · 2025: 16 · 2024: 12 · 2023: 20 · 2022: 17 · 2021: 10 · 2020: 12 · 2019: 7 · 2018: 9 · 2017: 14 · 2016: 13 · 2015: 6
FWCI
10.19
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
Funders
National Heart, Lung, and Blood Institute (HHSN268201300025C, HHSN268201300026C, HHSN268201300027C, HHSN268201300028C, HHSN268201300029C, and HHSN268200900041C)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
systolic blood pressure, diastolic blood pressure, left ventricular function, left ventricular systolic dysfunction, left ventricular diastolic dysfunction, longitudinal strain rate, middle age (human life stage), early adulthood, heart failure risk, CARDIA study
MeSH terms
Adolescent, Adult, Blood Pressure, Echocardiography, Female, Heart Diseases, Humans, Male, Middle Aged, Ventricular Dysfunction, Left, Young Adult

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