The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Assessment of Myocardial Microstructural Dynamics by In Vivo Diffusion Tensor Cardiac Magnetic Resonance
Open accessAbstract
BACKGROUND: Cardiomyocytes are organized in microstructures termed sheetlets that reorientate during left ventricular thickening. Diffusion tensor cardiac magnetic resonance (DT-CMR) may enable noninvasive interrogation of in vivo cardiac microstructural dynamics. Dilated cardiomyopathy (DCM) is a condition of abnormal myocardium with unknown sheetlet function. OBJECTIVES: This study sought to validate in vivo DT-CMR measures of cardiac microstructure against histology, characterize microstructural dynamics during left ventricular wall thickening, and apply the technique in hypertrophic cardiomyopathy (HCM) and DCM. METHODS: In vivo DT-CMR was acquired throughout the cardiac cycle in healthy swine, followed by in situ and ex vivo DT-CMR, then validated against histology. In vivo DT-CMR was performed in 19 control subjects, 19 DCM, and 13 HCM patients. RESULTS: = 0.89), were consistently observed under all experimental conditions, and accorded closely with histological analyses in both relaxed and contracted states. The potential contribution of cyclical strain effects to in vivo E2A was ∼17%. In healthy human control subjects, E2A increased from diastole (18°) to systole (65°; p < 0.001; E2A mobility = 45°). HCM patients showed significantly greater E2A in diastole than control subjects did (48°; p < 0.001) with impaired E2A mobility (23°; p < 0.001). In DCM, E2A was similar to control subjects in diastole, but systolic values were markedly lower (40°; p < 0.001) with impaired E2A mobility (20°; p < 0.001). CONCLUSIONS: Myocardial microstructure dynamics can be characterized by in vivo DT-CMR. Sheetlet function was abnormal in DCM with altered systolic conformation and reduced mobility, contrasting with HCM, which showed reduced mobility with altered diastolic conformation. These novel insights significantly improve understanding of contractile dysfunction at a level of noninvasive interrogation not previously available in humans.
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Cites
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Fiber Orientation in the Canine Left Ventricle during Diastole and Systole
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Self-citationPrognostic Significance of Myocardial Fibrosis in Hypertrophic Cardiomyopathy
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Agger, P., Ilkjær, C., Laustsen, C., Smerup, M., Frandsen, J. R., Ringgaard, S., Pedersen, M., Partridge, J. B., Anderson, R. H., & Hjortdal, V. (2016) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-017-0404-0 · Cited by 28
Carruth, E. D., Teh, I., Schneider, J. E., McCulloch, A. D., Omens, J. H., & Frank, L. R. (2020) · Journal of Cardiovascular Magnetic Resonance · doi:10.1186/s12968-020-00615-1 · Cited by 12
Assessing Myocardial Architecture: The Challenges and Controversies
Agger, P., & Stephenson, R. S. (2020) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd7040047 · Cited by 11
Metadata
- Authors
- Nielles-Vallespin, S., Khalique, Z., Ferreira, P. F., de Silva, R., Scott, A. D., Kilner, P., McGill, L.-A., Giannakidis, A., Gatehouse, P. D., Ennis, D., Aliotta, E., Al-Khalil, M., Kellman, P., Mazilu, D., Balaban, R. S., Firmin, D. N., Arai, A. E., & Pennell, D. J.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 69
- Issue
- 6
- Pages
- 661-676
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2586300595
- Cited by
- 267
- References
- 44
- FWCI
- 17.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nielles-Vallespin, S., Khalique, Z., Ferreira, P. F., de Silva, R., Scott, A. D., Kilner, P., McGill, L.-A., Giannakidis, A., Gatehouse, P. D., Ennis, D., Aliotta, E., Al-Khalil, M., Kellman, P., Mazilu, D., Balaban, R. S., Firmin, D. N., Arai, A. E., & Pennell, D. J. (2017). Assessment of Myocardial Microstructural Dynamics by In Vivo Diffusion Tensor Cardiac Magnetic Resonance. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2016.11.051
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