The Evolving Future of PCSK9 Inhibitors

Rosenson, Robert S., Hegele, Robert A., Fazio, Sergio, Cannon, Christopher P.·2018·Journal of the American College of Cardiology

Cited by (273)

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  16. Potential beneficial effect of treatment with PCSK9 inhibitors on vascular endothelial dysfunction: a systematic review and meta-analysis
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  19. Reduction of Cardiovascular Risk Using Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Patients With Acute Coronary Syndrome: A Systematic Review
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    Derek Leslie Connolly, Azfar Zaman, Nigel E. Capps, Steve C Bain, Kevin Fernando · 2023 · British Journal of Cardiology
  21. Combined Use of Statin and PCSK9 Inhibitor in a Pregnant Woman with Possible Familial Hypercholesterolemia and Coronary Artery Stenosis
    Yusaku Shimizu, Tae Yokouchi-Konishi, Chizuko Aoki-Kamiya, Mai Temukai, Kotaro Hizuka, Masami Sawada, A. Kakigano, N. Iwanaga, Takeshi Kanagawa, Kota Murai et al. · 2025 · Journal of atherosclerosis and thrombosis
  22. PCSK9 gene Polymorphism and Assessment of Cardiovascular Risk and Prognosis in Patients With Hyperlipidemia: A Retrospective Cohort Study
    Aibibanmu Aizezi, Fanhua Meng, Xiaolei Li, Yanpeng Li, Jialin Abuzhalihan, Fen Liu, Min-Tao Gai, Dilare Adi, Yi-Tong Ma · 2025 · Journal of Clinical Hypertension
  23. Association of Copper with Atherosclerosis and Treatment Strategies
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  24. ApoE-Knockout Mice: What are New Achievements of this Model of Atherosclerosis?
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  25. May need more comprehensive approach to residual risks in well controlled hypertensive patients
    Toru Suzuki, Daisuke Kamimura, Hiromichi Wakui, Kouichi Tamura · 2020 · Hypertension Research
  26. Atherosclerosis: Cholesterol Management
    Scott D. Edmondson, Duane A. Burnett, Harry R. Davis · 2021 · Wiley eBooks
  27. Reinforcing Adherence to Lipid-lowering Therapy after an Acute Coronary Syndrome: A Pragmatic Randomized Controlled Trial
    Stefanos Zafeiropoulos, Ioannis T. Farmakis, Αναστάσιος Κάρτας, Alexandra Arvanitaki, Konstantinos Arvanitakis, Vasileios Nevras, Areti Pagiantza, Stavros P. Zanos, George A. Giannakoulas · 2020 · Research Square
  28. Sequential Proofreading Enhances Specificity and Potency of CRISPR-CasX-based Epigenetic Repressors
    Emeric J. Charles, Ross White, Ryan Tran, Amanda Mok, Lea Alice Kiefer, Kirsten A. Reimer, Ashley T Wong, Sterling Ripley-Phipps, Natalie Goh, T.C. Stevenson Keller et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  29. Novel Therapies for Dyslipidemia
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  30. Hiperkolesterolemia Familiarra: patofisiologia, diagnostikoa eta tratamendua
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  35. Reinforcing Adherence to Lipid-lowering Therapy after an Acute Coronary Syndrome: A Pragmatic Randomized Controlled Trial
    Stefanos Zafeiropoulos, Ioannis T. Farmakis, George A. Giannakoulas, Αναστάσιος Κάρτας · 2020 · Research Square
  36. Dyslipidemias
    Cezary Wójcik · 2020 · Springer eBooks
  37. Inhibidores de PCSK9 en enfermedad cardiovascular
    Paul Mondragón‐Terán, Amy R. Rojas-Noverón · 2022 · Revista mexicana de enfermedades inflamatorias inmunomediadas
  38. Medikamentöse Therapie der Fettstoffwechselstörungen im Kindesalter
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  39. Acute impact of the early application of alirocumab on lipoprotein (a) and interleukin-6 in patients with unstable angina pectoris: a retrospective before-after study
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  40. Advanced therapeutics for targeting atherosclerosis
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  41. Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
    Corinne Carland, Grace Png, Anders Mälarstig, Pik Fang Kho, Stefan Gustafsson, Karl Michaëlsson, Lars Lind, Emmanouil Tsafantakis, Maria Karaleftheri, George V. Dedoussis et al. · 2023 · Research Square
  42. Special Patient Populations
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  43. Statins in Patients With Established Heart Failure: Time for Reflection
    Bertram Pitt, Robert S. Rosenson · 2023 · Journal of Cardiovascular Pharmacology
  44. RETRACTED ARTICLE: circABCA3 knockdown relieves hypoxia-induced human cardiac microvascular endothelial cell dysfunction by targeting the miR-671-5p/PCSK9 axis
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  45. Nuevos fármacos hipolipemiantes
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  46. PCSK9 inhibitors ameliorate arterial stiffness in ACS patients: evidences from mendelian randomization, cohort studies and basic experiments
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  47. Causal Relationship between Pcsk9 Inhibitor and Atrial Fibrillation: A Drug Target Mendelian Randomization Study
    Qiang Wang, Zihong Yang, Peizhuang Zhao, Xin Lin, Shuping Wen, Xinlong Zhang, Yaobing Xu · 2025 · SSRN Electronic Journal
  48. Low-density lipoprotein cholesterol levels and treatment intensity in secondary prevention of patients with ischaemic heart disease in the primary care setting: a real-world data registry study
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  49. Additional file 1 of Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction
    Sun, Ziyi, Yun, Zhangjun, Lin, Jianguo, Sun, Xiaoning, Qingqing Wang, Duan, Jinlong, Li, Cheng, Xiaoxiao Zhang, Xu, Siyu, Zeqi Wang et al. · 2024 · Figshare
  50. Additional file 3 of PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
    Chen, Ding-Qiang, Xu, Wen-Bin, Xiao, Ke-Yi, Zhiqiang Que, Feng Jinyi, 孙乃坤, Cai, Di-Xin, Gang Rui · 2024 · Figshare
  51. Additional file 7 of PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
    Chen, Ding-Qiang, Xu, Wen-Bin, Xiao, Ke-Yi, Que, Zhi-Qiang, Feng Jinyi, 孙乃坤, Cai, Di-Xin, Gang Rui · 2024 · Figshare
  52. Additional file 2 of Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction
    Sun, Ziyi, Yun, Zhangjun, Lin, Jianguo, Sun, Xiaoning, Qingqing Wang, Duan, Jinlong, Li, Cheng, Zhang, Xiaoxiao, Xu, Siyu, Zeqi Wang et al. · 2024 · Figshare
  53. Additional file 1 of Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
    Corinne Carland, Grace Png, Anders Mälarstig, Pik Fang Kho, Stefan Gustafsson, Michaelsson, Karl, Lind, Lars, Emmanouil Tsafantakis, Maria Karaleftheri, George V. Dedoussis et al. · 2024 · Figshare
  54. Additional file 6 of PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
    Chen, Ding-Qiang, Xu, Wen-Bin, Xiao, Ke-Yi, Que, Zhi-Qiang, Feng Jinyi, Sun, Nai-Kun, Cai, Di-Xin, Gang Rui · 2024 · Figshare
  55. Additional file 2 of Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
    Corinne Carland, Grace Png, Anders Mälarstig, Pik Fang Kho, Stefan Gustafsson, Michaelsson, Karl, Lind, Lars, Emmanouil Tsafantakis, Maria Karaleftheri, George V. Dedoussis et al. · 2024 · Figshare
  56. Additional file 1 of PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
    Chen, Ding-Qiang, Xu, Wen-Bin, Xiao, Ke-Yi, Zhiqiang Que, Feng Jinyi, Sun, Nai-Kun, Cai, Di-Xin, Gang Rui · 2024 · Figshare
  57. Additional file 5 of PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
    Chen, Ding-Qiang, Xu, Wen-Bin, Xiao, Ke-Yi, Que, Zhi-Qiang, Feng Jinyi, Sun, Nai-Kun, Cai, Di-Xin, Gang Rui · 2024 · Figshare
  58. Additional file 2 of Effect of alirocumab on cataracts in patients with acute coronary syndromes
    Gaspard Suc, Gregory G. Schwartz, Shaun G. Goodman, J. Wouter Jukema, Garen Z. Manvelian, Yann Poulouin, Robert C. Pordy, Michel Scemama, Michael J. Szarek, Philippe Gabríel Steg · 2023 · Figshare
  59. Additional file 1 of Effect of alirocumab on cataracts in patients with acute coronary syndromes
    Gaspard Suc, Gregory G. Schwartz, Shaun G. Goodman, J. Wouter Jukema, Garen Z. Manvelian, Yann Poulouin, Robert C. Pordy, Michel Scemama, Michael J. Szarek, Philippe Gabríel Steg · 2023 · Figshare
  60. Additional file 4 of PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
    Chen, Ding-Qiang, Xu, Wen-Bin, Xiao, Ke-Yi, Zhiqiang Que, Feng Jinyi, Sun, Nai-Kun, Cai, Di-Xin, Gang Rui · 2024 · Figshare
  61. Additional file 2 of PCSK9 inhibitors and osteoporosis: mendelian randomization and meta-analysis
    Chen, Ding-Qiang, Xu, Wen-Bin, Xiao, Ke-Yi, Zhiqiang Que, Feng Jinyi, Sun, Nai-Kun, Cai, Di-Xin, Gang Rui · 2024 · Figshare
  62. Le rôle du récepteur aux LDL et de PCSK9 dans le diabète de type 2
    Stéphane Ramin‐Mangata · 2020 · theses.fr (ABES)
  63. Rôle de la phosphatase alcaline non spécifique du tissu "TNAP" dans la calcification des plaques d’athérosclérose
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  64. Clinical identification of familial chylomicronemia syndrome and novel therapeutic options
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  65. Nanoparticle-Based PCSK9 Inhibition in Viral Infections: Evaluating Clinical Limitations and Advancing Therapeutic Strategies
    Moeen Fuad Dababneh, Bahjat Alhasso, Abdulkareem Shareef, Ashishkumar Kyada, H Malathi, Laxmidhar Maharana, Dinesh Puri, Harshit Gupta, N.A. Yarmukhamedova, Hayder Naji Sameer et al. · 2026 · Journal of Pharmaceutical Innovation
  66. Atherosclerosis features in rheumatic diseases – focus on peripheral artery disease
    Alexandr Ceasovschih, Alina Dima, Javier Rodríguez‐Carrio, Anastasia Balta, Raluca-Elena Alexa, Bianca Codrina Morărașu, Cătălina Lionte, Fotios Barkas, Maciej Banach, Victorița Șorodoc et al. · 2026 · Frontiers in Immunology
  67. Knowledge, Attitudes, and Practices Regarding PCSK9 Inhibitors Among Healthcare Professionals: Exploring Behavioral Pathways and the Intermediary Role of Attitude
    Chao Zhao, Nuan Wang, Dayong Shen, Laiyun Zhu, Guofang Chen · 2026 · Journal of Multidisciplinary Healthcare
  68. Association between PCSK9 targeted therapy and the risk of stroke and dementia: A meta-analysis of randomized controlled trials
    Vikash Jaiswal, Novonil Deb, Fakhar Latif, abhigan babu Shrestha, Vamsi Garimella, Nishat Shama, Sahas Reddy Jitta, Sidra Naz, Tushar Kumar, Shazia Khan et al. · 2026 · The American Journal of Medicine
  69. LRRC57/RABIN is a presynaptic inhibitor of Rab GTPases in glutamatergic neurons
    Dušan Garić, Jonathan G. Murphy, Brett J.W. Teubner, Christopher M. Davenport, Chablis D. Shreffler, Laura J. Janke, Woo Jung Cho, Zhiping Wu, Meghan G. McReynolds, Sarayut Phasuk et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  70. Enlicitide, a Novel Oral Macrocyclic Peptide PCSK9 Inhibitor for Lipid Lowering: A Systematic Review and Meta-Analysis
    Burcu Yağmur, Elif İjlal Çekirdekçi · 2026 · Journal of Cardiovascular Development and Disease
  71. Impact of Evolocumab on LDL‐Cholesterol and Cardiovascular Outcomes in Patients With Established CVD: Systematic Review and Meta‐Analysis
    Anika Goel, Muhammad ABDULLAH, Hemeesh Tandel, Affaf Mahmood, Muhammad Mukhlis, K. Sai Varun Reddy, Arun Kumar Maloth, Anchit Chauhan, Ameer Awashra, Amogh Verma et al. · 2026 · Endocrinology Diabetes & Metabolism
  72. BindingDB Entry 50020256: Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
    BindingDB · 2024 · UC San Diego
  73. BindingDB Entry 50018519: Recent Update on the Development of PCSK9 Inhibitors for Hypercholesterolemia Treatment.
    BindingDB · 2024 · UC San Diego