The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Sitting Time, Physical Activity, and Risk of Mortality in Adults
Open accessAbstract
BACKGROUND: It is unclear what level of moderate to vigorous intensity physical activity (MVPA) offsets the health risks of sitting. OBJECTIVES: The purpose of this study was to examine the joint and stratified associations of sitting and MVPA with all-cause and cardiovascular disease (CVD) mortality, and to estimate the theoretical effect of replacing sitting time with physical activity, standing, and sleep. METHODS: A longitudinal analysis of the 45 and Up Study calculated the multivariable-adjusted hazard ratios (HRs) of sitting for each sitting-MVPA combination group and within MVPA strata. Isotemporal substitution modeling estimated the per-hour HR effects of replacing sitting. RESULTS: A total of 8,689 deaths (1,644 due to CVD) occurred among 149,077 participants over an 8.9-year (median) follow-up. There was a statistically significant interaction between sitting and MVPA only for all-cause mortality. Sitting time was associated with both mortality outcomes in a nearly dose-response manner in the least active groups reporting <150 MVPA min/week. For example, among those reporting no MVPA, the all-cause mortality HR comparing the most sedentary (>8 h/day) to the least sedentary (<4 h/day) groups was 1.52 (95% confidence interval: 1.13 to 2.03). There was inconsistent and weak evidence for elevated CVD and all-cause mortality risks with more sitting among those meeting the lower (150 to 299 MVPA min/week) or upper (≥300 MVPA min/week) limits of the MVPA recommendation. Replacing sitting with walking and MVPA showed stronger associations among high sitters (>6 sitting h/day) where, for example, the per-hour CVD mortality HR for sitting replaced with vigorous activity was 0.36 (95% confidence interval: 0.17 to 0.74). CONCLUSIONS: Sitting is associated with all-cause and CVD mortality risk among the least physically active adults; moderate-to-vigorous physical activity doses equivalent to meeting the current recommendations attenuate or effectively eliminate such associations.
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KESSLER, R. C., ANDREWS, G., COLPE, L. J., HIRIPI, E., MROCZEK, D. K., NORMAND, S.-L. T., WALTERS, E. E., & ZASLAVSKY, A. M. (2002) · Psychological Medicine · doi:10.1017/s0033291702006074 · Cited by 10,327
The Physical Activity Guidelines for Americans
Piercy, K. L., Troiano, R. P., Ballard, R. M., Carlson, S. A., Fulton, J. E., Galuska, D. A., George, S. M., & Olson, R. D. (2018) · JAMA · doi:10.1001/jama.2018.14854 · Cited by 9,755 · cited 1×
“Physical Activity Guidelines Advisory Committee Scientific Report identified the paucity of prospective studies on the interactive effects of physical activity and sedentary behavior on all-cause and CVD mortality as a major evidence gap (10,11).”
Background(2007) · Circulation · doi:10.1161/circulationaha.107.185649 · Cited by 6,545
Self-citationLetter to the Editor: Standardized use of the terms “sedentary” and “sedentary behaviours”
Networ, S. B. R. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-024 · Cited by 1,873
Patterson, R., McNamara, E., Tainio, M., de Sá, T. H., Smith, A. D., Sharp, S. J., Edwards, P., Woodcock, J., Brage, S., & Wijndaele, K. (2018) · European Journal of Epidemiology · doi:10.1007/s10654-018-0380-1 · Cited by 1,423
Chastin, S. F. M., De Craemer, M., De Cocker, K., Powell, L., Van Cauwenberg, J., Dall, P., Hamer, M., & Stamatakis, E. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-097563 · Cited by 465
Self-citationRelationship of Sedentary Behavior and Physical Activity to Incident Cardiovascular Disease
Chomistek, A. K., Manson, J. E., Stefanick, M. L., Lu, B., Sands-Lincoln, M., Going, S. B., Garcia, L., Allison, M. A., Sims, S. T., LaMonte, M. J., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.03.031 · Cited by 389 · cited 2×
“Studies included in this review assessed independence by merely statistically adjusting for MVPA, an approach that is insufficient on its own, as it ignores evidence of effect modification (6,22,27,29).”
BackgroundResultKujala, U. M. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2017-098639 · Cited by 83
Cited by
Virani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001168 · Cited by 1,598
Virani, S. S., Newby, L. K., Arnold, S. V., Bittner, V., Brewer, L. C., Demeter, S. H., Dixon, D. L., Fearon, W. F., Hess, B., Johnson, H. M., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.04.003 · Cited by 596
Stamatakis, E., Owen, K. B., Shepherd, L., Drayton, B., Hamer, M., & Bauman, A. E. (2021) · Epidemiology · doi:10.1097/ede.0000000000001316 · Cited by 192
Self-citationWorldwide surveillance of self-reported sitting time: a scoping review
Mclaughlin, M., Atkin, A. J., Starr, L., Hall, A., Wolfenden, L., Sutherland, R., Wiggers, J., Ramirez, A., Hallal, P., Pratt, M., et al. (2020) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-020-01008-4 · Cited by 117
Bakker, E. A., van Bakel, B. M. A., Aengevaeren, W. R. M., Meindersma, E. P., Snoek, J. A., Waskowsky, W. M., van Kuijk, A. A., Jacobs, M. M. L. M., Hopman, M. T. E., Thijssen, D. H. J., et al. (2021) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.11.014 · Cited by 91
Metadata
- Authors
- Stamatakis, E., Gale, J., Bauman, A., Ekelund, U., Hamer, M., & Ding, D.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 73
- Issue
- 16
- Pages
- 2062-2072
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2936416719
- Cited by
- 683
- References
- 8
- FWCI
- 42.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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