Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment
Open accessPublished version of a preprint
Abstract
This is an update of the previous 2018 systematic review and meta-analysis of vitamin and mineral supplementation on cardiovascular disease outcomes and all-cause mortality. New randomized controlled trials and meta-analyses were identified by searching the Cochrane library, Medline, and Embase, and data were analyzed using random effects models and classified by the Grading of Recommendations Assessment Development and Evaluation approach. This updated review shows similar findings to the previous report for preventive benefits from both folic acid and B vitamins for stroke and has been graded with moderate quality. No effect was seen for the commonly used multivitamins, vitamin D, calcium, and vitamin C, and an increased risk was seen with niacin (with statin) for all-cause mortality. Conclusive evidence for the benefit of supplements across different dietary backgrounds, when the nutrient is sufficient, has not been demonstrated.
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References 66 · Cited by 110
Research works printed but not linked: 1
- Rees JR, Morris CB, Peacock JL, et al. Unmetab- olized folic acid, tetrahydrofolate, and colorectal ad- enoma risk. Cancer Prev Res (Phila) 2017;10:451-8.
- Authors
- Jenkins, D. J. A., Spence, J. D., Giovannucci, E. L., Kim, Y.-I., Josse, R. G., Vieth, R., Sahye-Pudaruth, S., Paquette, M., Patel, D., Blanco Mejia, S., Viguiliouk, E., Nishi, S. K., Kavanagh, M., Tsirakis, T., Kendall, C. W. C., Pichika, S. C., & Sievenpiper, J. L.
- Affiliations
- St. Michael's Hospital (CA)
- Western University (CA)
- Harvard University (US)
- University of Toronto (CA)
- Corresponding author
- Jenkins, David J.A.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 77
- Issue
- 4
- Pages
- 423-436
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W3122964697
- Cited by
- 110
- References
- 66
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 23 · 2023: 25 · 2022: 18 · 2021: 9
- Type
- supplementary materials
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- vitamin supplementation, mineral supplementation, cardiovascular disease prevention, stroke prevention, folic acid, B vitamins, multivitamins, vitamin D, calcium, vitamin C, nicotinic acid, all-cause mortality
- MeSH terms
- Cardiovascular Diseases, Humans, Diet, Vegetarian, Vitamin B Complex, Dietary Supplements, Stroke
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