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Dexrazoxane to Prevent Cardiotoxicity in Adults Treated with Anthracyclines
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“Pegylated liposomal doxorubicin (Doxil/Caelyx), for instance, showed similar efficacy endpoints with significantly reduced cardiotoxicity versus conventional doxorubicin in metastatic breast cancer, illustrating that the most consistent clinical value may be toxicity mitigation and exposure smoothing rather than reliably deeper parenchymal penetration[123].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [123]
In the citing paper
“illustrating that the most consistent clinical value may be toxicity mitigation and exposure smoothing rather than reliably deeper parenchymal penetration[123].”
From Overcoming tumor microenvironment barriers: transformable and bioinspired nanomedicine strategies for deep tumor penetration (2026) · cites this paper as [123]
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Research works printed but not linked: 9
- de Baat, 2022, Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines, Cochrane Database Syst Rev, 9, CD014638
- Marty, 2006, Multicenter randomized phase III study of the cardioprotective effect of dexrazoxane (Cardioxane) in advanced/metastatic breast cancer patients treated with anthracycline-based chemotherapy, Ann Oncol, 17, 614, 10.1093/annonc/mdj134 · DOI
- O’Brien, 2004, Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer, Ann Oncol, 15, 440, 10.1093/annonc/mdh097 · DOI
- Jones, 2021, Prospective evaluation of doxorubicin cardiotoxicity in patients with advanced soft-tissue sarcoma treated in the ANNOUNCE phase III randomized trial, Clin Cancer Res, 27, 3861, 10.1158/1078-0432.CCR-20-4592 · DOI
- Salz, 2017, Preexisting cardiovascular risk and subsequent heart failure among non-Hodgkin lymphoma survivors, J Clin Oncol, 35, 3837, 10.1200/JCO.2017.72.4211 · DOI
- Armenian, 2017, Prevention and monitoring of cardiac dysfunction in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline summary, J Oncol Pract, 13, 270, 10.1200/JOP.2016.018770 · DOI
- Lyon, 2022, 2022 ESC guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS), Eur Heart J, 23, e333
- Ganatra, 2019, Upfront dexrazoxane for the reduction of anthracycline-induced cardiotoxicity in adults with preexisting cardiomyopathy and cancer: a consecutive case series, Cardiooncology, 5, 1
- Upshaw, 2023, Association of preexisting heart failure with outcomes in older patients with diffuse large B-cell lymphoma, JAMA Cardiol, 8, 453, 10.1001/jamacardio.2023.0303 · DOI
Cited by
Sorted by citations
Sheng, J., Yuan, W., Zhang, M., Chen, Z., Qi, Y., Zhao, Y., & Zhang, S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04028-7 · Cited by 35
Metadata
- Authors
- Upshaw, J. N., Parson, S. K., Buchsbaum, R. J., Schlam, I., Ruddy, K. J., Durani, U., Epperla, N., & Leong, D. P.
- Venue
- JACC: CardioOncology
- Publisher
- Elsevier BV
- Published
- 2024-04
- Volume
- 6
- Issue
- 2
- Pages
- 322-324
- ISSN
- 2666-0873
- PMC
- PMC11103024
- Cited by
- 49
- References
- 0
- Language
- en
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