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Cited by 65Immunotherapy and Immune ResponsesChemokine receptors and signalingCell Adhesion Molecules Research

Skin homing of Langerhans cell precursors: Adhesion, chemotaxis, and migration

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Koch, Susanne, Kohl, Kristine, Klein, Elisabeth, von Bubnoff, Dagmar, Bieber, Thomas·2006·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2005.10.003
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Abstract

Langerhans cells (LCs) are epidermal antigen-presenting dendritic cells. They contain unique granules, known as Birbeck granules, which are substructures of the endosomal recycling compartment. LCs migrate from the epidermis to the regional lymph nodes for presentation of antigenic peptides to T cells. There LCs either initiate a primary immune response or induce antigen-specific tolerance. The replenishment of the LC pool in the epidermis is the topic of this review. Chemokines produced by epidermal keratinocytes and by dermal fibroblasts guide the arrest of LC precursors on endothelial cells of dermal venules, followed by their transmigration through endothelium and dermis toward the epidermis. One necessary prerequisite for this is the coordinated expression of adhesion receptors and counter-receptors on LC precursors and on endothelial and dermal cells. LC precursors attach to and degrade basement membrane proteins to penetrate the dermal matrix and the basement membrane of the dermal-epidermal junction. LC migration depends on the activity of matrix metalloproteinases, which are proteolytic endopeptidases cleaving matrix components. Matrix metalloproteinases also execute an important role in modulating inflammatory and immune responses by processing chemokines, which turns them into dual players for the immigration of LC precursors into the epidermis.

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  • Langerhans cells are professional antigen presenting cells in the epidermis and their long dendritic structures comprise the first line immunological barriers.

    “LCs are professional antigen presenting cells (APCs) in the epidermis of the skin, and their long dendritic structures comprise the first line immunological barriers [6].”

    From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [6]

    The Abstract identifies Langerhans cells as epidermal antigen-presenting dendritic cells and calls them a critical immune outpost at the interface with the external environment. The Conclusion likewise describes their role in controlling immune responses. Neither passage says that their dendritic structures are long or that those structures comprise a first-line immunological barrier; page numbers are unavailable in our copy. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Koch, S., Kohl, K., Klein, E., von Bubnoff, D., & Bieber, T.
Affiliations
University of Bonn (DE)
Corresponding author
Koch, Susanne
ORCID
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2006-01
Volume
117
Issue
1
Pages
163-168
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2005.10.003
OpenAlex
W2138742397
Cited by
65
References
1
Citations by year
2024: 1 · 2023: 3 · 2022: 2 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 5
FWCI
0.56
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
Langerhans cells, skin homing, dendritic cells, chemokines, cell adhesion receptors, endothelial cell adhesion, transmigration, basement membrane degradation, basement membrane zone, matrix metalloproteinases, chemokine processing, antigen presentation, epidermal keratinocytes, dermal fibroblasts
MeSH terms
Animals, Cell Adhesion, Cell Movement, Chemotaxis, Dendritic Cells, Humans, Immunoglobulins, Langerhans Cells, Membrane Proteins, Monocytes, Skin, Stem Cells, Signal Transduction, Keratinocytes, Cell Adhesion Molecules, Platelet Endothelial Cell Adhesion Molecule-1, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9

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