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Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica

Hunninghake, Gary M., Soto-Quiros, Manuel E., Avila, Lydiana, Ly, Ngoc P., Liang, Catherine, Sylvia, Jody S., Klanderman, Barbara J., Silverman, Edwin K., Celedón, Juan C.·2007·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2006.12.609
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Abstract

Background Little is known about sensitization (defined as a positive IgE) to helminths and disease severity in patients with asthma. Objectives To examine the relationship between sensitization (defined as a positive IgE) to Ascaris lumbricoides and measures of asthma morbidity and severity in a Costa Rican population with low prevalence of parasitic infection but high prevalence of parasitic exposure. Methods Cross-sectional study of 439 children (ages 6 to 14 years) with asthma. Linear regression and logistic regression were used for the multivariate statistical analysis. Results After adjustment for parental education and other covariates, sensitization to Ascaris lumbricoides was associated with having at least 1 positive skin test to allergens (odds ratio, 5.15; 95% CI, 2.36-11.21; P Conclusion Sensitization to Ascaris lumbricoides is associated with increased severity and morbidity of asthma among children in Costa Rica. This association is likely mediated by an increased degree of atopy among children with asthma who are sensitized to Ascaris. Clinical implications In areas with a low prevalence of helminthiasis such as Costa Rica, Ascaris sensitization may be an important marker of severe atopy and disease morbidity in children with asthma.

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Metadata

Authors
Hunninghake, G. M., Soto-Quiros, M. E., Avila, L., Ly, N. P., Liang, C., Sylvia, J. S., Klanderman, B. J., Silverman, E. K., & Celedón, J. C.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2007-03
Volume
119
Issue
3
Pages
654-661
ISSN
0091-6749
DOI
10.1016/j.jaci.2006.12.609
Cited by
138
References
0
Language
en
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CoChat. (2026). Citation check: Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. https://app.cochat.ai/papers/10.1016/j.jaci.2006.12.609
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Hunninghake, G. M., Soto-Quiros, M. E., Avila, L., Ly, N. P., Liang, C., Sylvia, J. S., Klanderman, B. J., Silverman, E. K., & Celedón, J. C. (2007). Sensitization to Ascaris lumbricoides and severity of childhood asthma in Costa Rica. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2006.12.609