Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways

Liu, Weimin; Liang, Qiaoling; Balzar, Silvana; Wenzel, Sally; Gorska, Magdalena; Alam, Rafeul

doi:10.1016/j.jaci.2008.02.004

Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways

Background Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown. Objectives We sought to study the activation of the mitogen-activated protein kinase (MAPK) signaling pathway in airway cells. Methods Endobronchial biopsy specimens f…